Sleep-wake patterns are altered with age, Prdm13 signaling in the DMH, and diet restriction in mice.


Journal

Life science alliance
ISSN: 2575-1077
Titre abrégé: Life Sci Alliance
Pays: United States
ID NLM: 101728869

Informations de publication

Date de publication:
06 2023
Historique:
received: 16 02 2023
revised: 17 03 2023
accepted: 17 03 2023
medline: 14 4 2023
entrez: 12 4 2023
pubmed: 13 4 2023
Statut: epublish

Résumé

Old animals display significant alterations in sleep-wake patterns such as increases in sleep fragmentation and sleep propensity. Here, we demonstrated that PR-domain containing protein 13 (Prdm13)+ neurons in the dorsomedial hypothalamus (DMH) are activated during sleep deprivation (SD) in young mice but not in old mice. Chemogenetic inhibition of Prdm13+ neurons in the DMH in young mice promotes increase in sleep attempts during SD, suggesting its involvement in sleep control. Furthermore, DMH-specific

Identifiants

pubmed: 37045472
pii: 6/6/e202301992
doi: 10.26508/lsa.202301992
pmc: PMC10105329
pii:
doi:

Substances chimiques

Prdm13 protein, mouse EC 2.1.1.-
Histone-Lysine N-Methyltransferase EC 2.1.1.43
Transcription Factors 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2023 Tsuji et al.

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Auteurs

Shogo Tsuji (S)

Department of Integrative Physiology, National Center for Geriatrics and Gerontology (NCGG), Obu, Japan.

Cynthia S Brace (CS)

Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.

Ruiqing Yao (R)

Department of Integrative Physiology, National Center for Geriatrics and Gerontology (NCGG), Obu, Japan.

Yoshitaka Tanie (Y)

Department of Integrative Physiology, National Center for Geriatrics and Gerontology (NCGG), Obu, Japan.

Hirobumi Tada (H)

Department of Integrative Physiology, National Center for Geriatrics and Gerontology (NCGG), Obu, Japan.
Department of Nutrition, Faculty of Wellness, Shigakkan University, Obu, Japan.
Department of Physiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Nicholas Rensing (N)

Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.

Seiya Mizuno (S)

Laboratory Animal Resource Center, University of Tsukuba, Tsukuba, Japan.

Julio Almunia (J)

Laboratory of Experimental Animals, NCGG, Obu, Japan.

Yingyi Kong (Y)

Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Kazuhiro Nakamura (K)

Department of Integrative Physiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Takahisa Furukawa (T)

Laboratories for Molecular and Developmental Biology, Institute for Protein Research, Osaka University, Osaka, Japan.

Noboru Ogiso (N)

Laboratory of Experimental Animals, NCGG, Obu, Japan.

Shinya Toyokuni (S)

Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Satoru Takahashi (S)

Laboratory Animal Resource Center, University of Tsukuba, Tsukuba, Japan.

Michael Wong (M)

Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.

Shin-Ichiro Imai (SI)

Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.
Department of Gerontology, Laboratory of Molecular Life Science, Institute of Biomedical Research and Innovation, Kobe, Japan.

Akiko Satoh (A)

Department of Integrative Physiology, National Center for Geriatrics and Gerontology (NCGG), Obu, Japan asatoh@ncgg.go.jp.
Department of Integrative Physiology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan.

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Classifications MeSH