Genomic-transcriptomic evolution in lung cancer and metastasis.
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
received:
21
10
2021
accepted:
04
01
2023
medline:
21
4
2023
pubmed:
13
4
2023
entrez:
12
4
2023
Statut:
ppublish
Résumé
Intratumour heterogeneity (ITH) fuels lung cancer evolution, which leads to immune evasion and resistance to therapy
Identifiants
pubmed: 37046093
doi: 10.1038/s41586-023-05706-4
pii: 10.1038/s41586-023-05706-4
pmc: PMC10115639
doi:
Substances chimiques
APOBEC3A protein, human
EC 3.5.4.5
ADAR protein, human
EC 3.5.4.37
Banques de données
ClinicalTrials.gov
['NCT01888601']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
543-552Subventions
Organisme : Cancer Research UK
ID : CTRNBC-2022/100001
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L016311/1
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 21999
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 24956
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 17786
Pays : United Kingdom
Organisme : Arthritis Research UK
ID : CC2008
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/W025051/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/V033077/1
Pays : United Kingdom
Organisme : Arthritis Research UK
ID : CC2041
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 29569
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 30025
Pays : United Kingdom
Investigateurs
Nicholas McGranahan
(N)
Charles Swanton
(C)
Maise Al Bakir
(MA)
Emilia L Lim
(EL)
Alexander M Frankell
(AM)
Kevin Litchfield
(K)
Nicolai J Birkbak
(NJ)
Peter Van Loo
(P)
Jason F Lester
(JF)
Amrita Bajaj
(A)
Apostolos Nakas
(A)
Azmina Sodha-Ramdeen
(A)
Keng Ang
(K)
Mohamad Tufail
(M)
Mohammed Fiyaz Chowdhry
(MF)
Molly Scotland
(M)
Rebecca Boyles
(R)
Sridhar Rathinam
(S)
Claire Wilson
(C)
Domenic Marrone
(D)
Sean Dulloo
(S)
Dean A Fennell
(DA)
Gurdeep Matharu
(G)
Jacqui A Shaw
(JA)
Joan Riley
(J)
Lindsay Primrose
(L)
Ekaterini Boleti
(E)
Heather Cheyne
(H)
Mohammed Khalil
(M)
Shirley Richardson
(S)
Tracey Cruickshank
(T)
Gillian Price
(G)
Keith M Kerr
(KM)
Sarah Benafif
(S)
Kayleigh Gilbert
(K)
Babu Naidu
(B)
Akshay J Patel
(AJ)
Aya Osman
(A)
Christer Lacson
(C)
Gerald Langman
(G)
Helen Shackleford
(H)
Madava Djearaman
(M)
Salma Kadiri
(S)
Gary Middleton
(G)
Angela Leek
(A)
Jack Davies Hodgkinson
(JD)
Nicola Totten
(N)
Angeles Montero
(A)
Elaine Smith
(E)
Eustace Fontaine
(E)
Felice Granato
(F)
Helen Doran
(H)
Juliette Novasio
(J)
Kendadai Rammohan
(K)
Leena Joseph
(L)
Paul Bishop
(P)
Rajesh Shah
(R)
Stuart Moss
(S)
Vijay Joshi
(V)
Philip Crosbie
(P)
Fabio Gomes
(F)
Kate Brown
(K)
Mathew Carter
(M)
Anshuman Chaturvedi
(A)
Lynsey Priest
(L)
Pedro Oliveira
(P)
Colin R Lindsay
(CR)
Fiona H Blackhall
(FH)
Matthew G Krebs
(MG)
Yvonne Summers
(Y)
Alexandra Clipson
(A)
Jonathan Tugwood
(J)
Alastair Kerr
(A)
Dominic G Rothwell
(DG)
Elaine Kilgour
(E)
Caroline Dive
(C)
Hugo J W L Aerts
(HJWL)
Roland F Schwarz
(RF)
Tom L Kaufmann
(TL)
Zoltan Szallasi
(Z)
Judit Kisistok
(J)
Mateo Sokac
(M)
Miklos Diossy
(M)
Abigail Bunkum
(A)
Aengus Stewart
(A)
Alastair Magness
(A)
Angeliki Karamani
(A)
Benny Chain
(B)
Brittany B Campbell
(BB)
Chris Bailey
(C)
Christopher Abbosh
(C)
Clare E Weeden
(CE)
Claudia Lee
(C)
Corentin Richard
(C)
Crispin T Hiley
(CT)
David R Pearce
(DR)
Despoina Karagianni
(D)
Dhruva Biswas
(D)
Dina Levi
(D)
Elena Hoxha
(E)
Emma Nye
(E)
Eva Grönroos
(E)
Felip Gálvez-Cancino
(F)
Francisco Gimeno-Valiente
(F)
George Kassiotis
(G)
Georgia Stavrou
(G)
Gerasimos Mastrokalos
(G)
Haoran Zhai
(H)
Helen L Lowe
(HL)
Ignacio Garcia Matos
(IG)
Jacki Goldman
(J)
James L Reading
(JL)
Javier Herrero
(J)
Jayant K Rane
(JK)
Jerome Nicod
(J)
Jie Min Lam
(JM)
John A Hartley
(JA)
Karl S Peggs
(KS)
Katey S S Enfield
(KSS)
Kayalvizhi Selvaraju
(K)
Kevin W Ng
(KW)
Kezhong Chen
(K)
Krijn Dijkstra
(K)
Kristiana Grigoriadis
(K)
Krupa Thakkar
(K)
Leah Ensell
(L)
Mansi Shah
(M)
Marcos Vasquez Duran
(MV)
Maria Litovchenko
(M)
Mariana Werner Sunderland
(MW)
Michelle Leung
(M)
Mickael Escudero
(M)
Mihaela Angelova
(M)
Monica Sivakumar
(M)
Olga Chervova
(O)
Olivia Lucas
(O)
Othman Al-Sawaf
(O)
Philip Hobson
(P)
Piotr Pawlik
(P)
Richard Kevin Stone
(RK)
Robert Bentham
(R)
Robert E Hynds
(RE)
Roberto Vendramin
(R)
Sadegh Saghafinia
(S)
Saioa López
(S)
Samuel Gamble
(S)
Seng Kuong Anakin Ung
(SKA)
Sergio A Quezada
(SA)
Sharon Vanloo
(S)
Simone Zaccaria
(S)
Sonya Hessey
(S)
Stefan Boeing
(S)
Supreet Kaur Bola
(SK)
Tamara Denner
(T)
Teresa Marafioti
(T)
Thanos P Mourikis
(TP)
Victoria Spanswick
(V)
Vittorio Barbè
(V)
Wei-Ting Lu
(WT)
William Hill
(W)
Wing Kin Liu
(WK)
Yin Wu
(Y)
Yutaka Naito
(Y)
Zoe Ramsden
(Z)
Catarina Veiga
(C)
Gary Royle
(G)
Charles-Antoine Collins-Fekete
(CA)
Francesco Fraioli
(F)
Paul Ashford
(P)
Tristan Clark
(T)
Martin D Forster
(MD)
Siow Ming Lee
(SM)
Elaine Borg
(E)
Mary Falzon
(M)
Dionysis Papadatos-Pastos
(D)
James Wilson
(J)
Tanya Ahmad
(T)
Alexander James Procter
(AJ)
Asia Ahmed
(A)
Magali N Taylor
(MN)
Arjun Nair
(A)
David Lawrence
(D)
Davide Patrini
(D)
Neal Navani
(N)
Ricky M Thakrar
(RM)
Sam M Janes
(SM)
Emilie Martinoni Hoogenboom
(EM)
Fleur Monk
(F)
James W Holding
(JW)
Junaid Choudhary
(J)
Kunal Bhakhri
(K)
Marco Scarci
(M)
Martin Hayward
(M)
Nikolaos Panagiotopoulos
(N)
Pat Gorman
(P)
Reena Khiroya
(R)
Robert C M Stephens
(RCM)
Yien Ning Sophia Wong
(YNS)
Steve Bandula
(S)
Abigail Sharp
(A)
Sean Smith
(S)
Nicole Gower
(N)
Harjot Kaur Dhanda
(HK)
Kitty Chan
(K)
Camilla Pilotti
(C)
Rachel Leslie
(R)
Anca Grapa
(A)
Hanyun Zhang
(H)
Khalid AbdulJabbar
(K)
Xiaoxi Pan
(X)
Yinyin Yuan
(Y)
David Chuter
(D)
Mairead MacKenzie
(M)
Serena Chee
(S)
Aiman Alzetani
(A)
Judith Cave
(J)
Lydia Scarlett
(L)
Jennifer Richards
(J)
Papawadee Ingram
(P)
Silvia Austin
(S)
Eric Lim
(E)
Paulo De Sousa
(P)
Simon Jordan
(S)
Alexandra Rice
(A)
Hilgardt Raubenheimer
(H)
Harshil Bhayani
(H)
Lyn Ambrose
(L)
Anand Devaraj
(A)
Hema Chavan
(H)
Sofina Begum
(S)
Silviu I Buderi
(SI)
Daniel Kaniu
(D)
Mpho Malima
(M)
Sarah Booth
(S)
Andrew G Nicholson
(AG)
Nadia Fernandes
(N)
Pratibha Shah
(P)
Chiara Proli
(C)
Madeleine Hewish
(M)
Sarah Danson
(S)
Michael J Shackcloth
(MJ)
Lily Robinson
(L)
Peter Russell
(P)
Kevin G Blyth
(KG)
Craig Dick
(C)
John Le Quesne
(J)
Alan Kirk
(A)
Mo Asif
(M)
Rocco Bilancia
(R)
Nikos Kostoulas
(N)
Mathew Thomas
(M)
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2023. The Author(s).
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