Role of Muscarinic Acetylcholine Receptors in Intestinal Epithelial Homeostasis: Insights for the Treatment of Inflammatory Bowel Disease.
acetylcholine
epithelial barrier
homeostasis
inflammatory bowel disease
muscarinic receptor
non-neuronal acetylcholine
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
30 Mar 2023
30 Mar 2023
Historique:
received:
28
02
2023
revised:
27
03
2023
accepted:
28
03
2023
medline:
14
4
2023
entrez:
13
4
2023
pubmed:
14
4
2023
Statut:
epublish
Résumé
Inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, is an intestinal disorder that causes prolonged inflammation of the gastrointestinal tract. Currently, the etiology of IBD is not fully understood and treatments are insufficient to completely cure the disease. In addition to absorbing essential nutrients, intestinal epithelial cells prevent the entry of foreign antigens (micro-organisms and undigested food) through mucus secretion and epithelial barrier formation. Disruption of the intestinal epithelial homeostasis exacerbates inflammation. Thus, the maintenance and reinforcement of epithelial function may have therapeutic benefits in the treatment of IBD. Muscarinic acetylcholine receptors (mAChRs) are G protein-coupled receptors for acetylcholine that are expressed in intestinal epithelial cells. Recent studies have revealed the role of mAChRs in the maintenance of intestinal epithelial homeostasis. The importance of non-neuronal acetylcholine in mAChR activation in epithelial cells has also been recognized. This review aimed to summarize recent advances in research on mAChRs for intestinal epithelial homeostasis and the involvement of non-neuronal acetylcholine systems, and highlight their potential as targets for IBD therapy.
Identifiants
pubmed: 37047478
pii: ijms24076508
doi: 10.3390/ijms24076508
pmc: PMC10095461
pii:
doi:
Substances chimiques
Acetylcholine
N9YNS0M02X
Receptors, Muscarinic
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : The Smoking Research Foundation of Japan
ID : 2021G008, 2020G006
Organisme : Japan Society for the Promotion of Science
ID : 19K09794, 22K07358, 22K06637
Organisme : Kobayashi Pharmaceutical (Japan)
ID : no.181
Organisme : Akiyama Life Science Foundation
ID : 141-032
Organisme : The Grant of National Center for Child Health and Development
ID : 2021-A1
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