Metalloporphyrins as Tools for Deciphering the Role of Heme Oxygenase in Renal Immune Injury.
heme oxygenase
immune mediated
renal injury
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
06 Apr 2023
06 Apr 2023
Historique:
received:
14
03
2023
revised:
31
03
2023
accepted:
03
04
2023
medline:
14
4
2023
entrez:
13
4
2023
pubmed:
14
4
2023
Statut:
epublish
Résumé
Renal immune injury is a frequent cause of end-stage renal disease, and, despite the progress made in understanding underlying pathogenetic mechanisms, current treatments to preserve renal function continue to be based mainly on systemic immunosuppression. Small molecules, naturally occurring biologic agents, show considerable promise in acting as disease modifiers and may provide novel therapeutic leads. Certain naturally occurring or synthetic Metalloporphyrins (Mps) can act as disease modifiers by increasing heme oxygenase (HO) enzymatic activity and/or synthesis of the inducible HO isoform (HO-1). Depending on the metal moiety of the Mp employed, these effects may occur in tandem or can be discordant (increased HO-1 synthesis but inhibition of enzyme activity). This review discusses effects of Mps, with varying redox-active transitional metals and cyclic porphyrin cores, on mechanisms underlying pathogenesis and outcomes of renal immune injury.
Identifiants
pubmed: 37047787
pii: ijms24076815
doi: 10.3390/ijms24076815
pmc: PMC10095062
pii:
doi:
Substances chimiques
Heme Oxygenase (Decyclizing)
EC 1.14.14.18
Metalloporphyrins
0
Heme Oxygenase-1
EC 1.14.14.18
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : a Veteran Affairs Merit Award, titled 'Novel Complement-targeted treatment strategies' awarded to Elias A. Lianos.
ID : 5I01BX004333-04
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