Effects on Serum Hormone Concentrations after a Dietary Phytoestrogen Intervention in Patients with Prostate Cancer: A Randomized Controlled Trial.

Male Humans Phytoestrogens Estrogen Receptor beta / genetics Isoflavones Prostatic Neoplasms Testosterone Estradiol
estradiol insulin-like growth factor 1 isoflavones lignans phytoestrogens prostate cancer sex hormone-binding globulin testosterone

Journal

Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595

Informations de publication

Date de publication:
06 Apr 2023
Historique:
received: 10 03 2023
revised: 29 03 2023
accepted: 04 04 2023
medline: 14 4 2023
entrez: 13 4 2023
pubmed: 14 4 2023
Statut: epublish

Résumé

Phytoestrogens have been suggested to have an anti-proliferative role in prostate cancer, potentially by acting through estrogen receptor beta (ERβ) and modulating several hormones. We primarily aimed to investigate the effect of a phytoestrogen intervention on hormone concentrations in blood depending on the ERβ genotype. Patients with low and intermediate-risk prostate cancer, scheduled for radical prostatectomy, were randomized to an intervention group provided with soybeans and flaxseeds (∼200 mg phytoestrogens/d) added to their diet until their surgery, or a control group that was not provided with any food items. Both groups received official dietary recommendations. Blood samples were collected at baseline and endpoint and blood concentrations of different hormones and phytoestrogens were analyzed. The phytoestrogen-rich diet did not affect serum concentrations of testosterone, insulin-like growth factor 1, or sex hormone-binding globulin (SHBG). However, we found a trend of decreased risk of increased serum concentration of estradiol in the intervention group compared to the control group but only in a specific genotype of ERβ (

Identifiants

DOI: 10.3390/nu15071792 PMID: 37049632 PMC: PMC10097251
pubmed: 37049632
pii: nu15071792
doi: 10.3390/nu15071792
pmc: PMC10097251
pii:
doi:

Substances chimiques

Phytoestrogens 0
Estrogen Receptor beta 0
Isoflavones 0
Testosterone 3XMK78S47O
Estradiol 4TI98Z838E

Types de publication

Randomized Controlled Trial Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : LUA/ALF agreement in the West of Sweden health care region
ID : ALFGBG-727821, ALFGBG-966360
Organisme : King Gustav V Jubilee Clinic Research Foundation at Sahlgrenska University Hospital
ID : 2021:353, 2020:320, 2019:262, 2018:206, 2017:145, 2016:76
Organisme : Dr.P.Håkansson's Foundation, Eslöv, Sweden
ID : Maria Hedelin 2014
Organisme : Patientföreningen för prostatacancer ProLiv Väst
ID : Maria Hedelin
Organisme : Lions Cancerfond Väst
ID : 2013;10
Organisme : Knut and Alice Wallenberg Foundation
ID : KAW 2015.0114

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Auteurs

Rebecca Ahlin (R)

Department of Oncology, Division of Clinical Cancer Epidemiology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 40530 Gothenburg, Sweden.
ORCID: 0000-0002-9857-666X

Natalja P Nørskov (NP)

Department of Animal and Veterinary Sciences, Aarhus University, AU-Foulum, 8830 Tjele, Denmark.

Sanna Nybacka (S)

Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 41345 Gothenburg, Sweden.
ORCID: 0000-0001-9299-1929

Rikard Landberg (R)

Department of Life Sciences, Division of Food and Nutrition Science, Chalmers University of Technology, 41296 Gothenburg, Sweden.

Viktor Skokic (V)

Department of Oncology, Division of Clinical Cancer Epidemiology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 40530 Gothenburg, Sweden.
Department of Molecular Medicine and Surgery, Karolinska Institute, 17176 Stockholm, Sweden.
Department of Pelvic Cancer, Karolinska University Hospital, 17176 Stockholm, Sweden.

Johan Stranne (J)

Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 40530 Gothenburg, Sweden.
Region Västra Götaland, Department of Urology, Sahlgrenska University Hospital, 41345 Gothenburg, Sweden.

Andreas Josefsson (A)

Sahlgrenska Cancer Center, Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 41345 Gothenburg, Sweden.
Wallenberg Center for Molecular Medicine, Umeå University, 90187 Umeå, Sweden.
Department of Urology and Andrology, Institute of Surgery and Perioperative Sciences, Umeå University, 90187 Umeå, Sweden.

Gunnar Steineck (G)

Department of Oncology, Division of Clinical Cancer Epidemiology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 40530 Gothenburg, Sweden.

Maria Hedelin (M)

Department of Oncology, Division of Clinical Cancer Epidemiology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 40530 Gothenburg, Sweden.
Regional Cancer Center West, Sahlgrenska University Hospital, Region Västra Götaland, 41345 Gothenburg, Sweden.
ORCID: 0000-0002-8917-2495

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Effects on Serum Hormone Concentrations after...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hormones, substituts d'hormones et antagonistes d'hormones › Hormones › Oestrogènes › Oestrogènes nonstéroïdiens › Phyto-oestrogènes › Effects on Serum Hormone Concentrations after...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteur bêta des oestrogènes › Effects on Serum Hormone Concentrations after...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › Isoflavones › Effects on Serum Hormone Concentrations after...
questionsmedicales.fr › Maladies urogénitales › Tumeurs de l'appareil urogénital › Tumeurs de l'appareil génital mâle › Tumeurs de la prostate › Effects on Serum Hormone Concentrations after...
questionsmedicales.fr › Hormones gonadiques › Hormones sexuelles stéroïdiennes › Congénères de la testostérone › Testostérone › Effects on Serum Hormone Concentrations after...
questionsmedicales.fr › Hormones gonadiques › Hormones sexuelles stéroïdiennes › Congénères de l'oestradiol › Oestradiol › Effects on Serum Hormone Concentrations after...