Correlated particle transport enables biological free energy transduction.
bacterial nanowires
biological transport networks
electron bifurcation
free energy transduction
many-particle transport kinetics
master equation
mean-field approximation
redox-coupled proton pump
Journal
Biophysical journal
ISSN: 1542-0086
Titre abrégé: Biophys J
Pays: United States
ID NLM: 0370626
Informations de publication
Date de publication:
16 05 2023
16 05 2023
Historique:
received:
21
12
2022
revised:
17
02
2023
accepted:
07
04
2023
pmc-release:
16
05
2024
medline:
19
5
2023
pubmed:
15
4
2023
entrez:
14
4
2023
Statut:
ppublish
Résumé
Studies of biological transport frequently neglect the explicit statistical correlations among particle site occupancies (i.e., they use a mean-field approximation). Neglecting correlations sometimes captures biological function, even for out-of-equilibrium and interacting systems. We show that neglecting correlations fails to describe free energy transduction, mistakenly predicting an abundance of slippage and energy dissipation, even for networks that are near reversible and lack interactions among particle sites. Interestingly, linear charge transport chains are well described without including correlations, even for networks that are driven and include site-site interactions typical of biological electron transfer chains. We examine three specific bioenergetic networks: a linear electron transfer chain (as found in bacterial nanowires), a near-reversible electron bifurcation network (as in complex III of respiration and other recently discovered structures), and a redox-coupled proton pump (as in complex IV of respiration).
Identifiants
pubmed: 37056051
pii: S0006-3495(23)00239-4
doi: 10.1016/j.bpj.2023.04.009
pmc: PMC10209040
pii:
doi:
Substances chimiques
Protons
0
Electron Transport Complex IV
EC 1.9.3.1
Proton Pumps
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1762-1771Informations de copyright
Copyright © 2023 Biophysical Society. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
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