Phospholipid-Coated Boronic Oxide Nanoparticles as Boron Agents for Boron Neutron Capture Therapy.

Boron Phospholipids Boron Neutron Capture Therapy Boron Compounds / therapeutic use Nanoparticles Oxides
boron neutron capture therapy drug delivery systems lipid nanoparticles organic-inorganic hybrid nanomaterials

Journal

Chembiochem : a European journal of chemical biology
ISSN: 1439-7633
Titre abrégé: Chembiochem
Pays: Germany
ID NLM: 100937360

Informations de publication

Date de publication:
01 08 2023
Historique:
revised: 03 04 2023
received: 08 03 2023
medline: 2 8 2023
pubmed: 18 4 2023
entrez: 17 4 2023
Statut: ppublish

Résumé

Minimally invasive boron neutron capture therapy (BNCT) is an elegant approach for cancer treatment. The highly selective and efficient deliverability of boron agents to cancer cells is the key to maximizing the therapeutic benefits of BNCT. In addition, enhancement of the frequencies to achieve boron neutron capture reaction is also significant in improving therapeutic efficacy by providing a highly concentrated boron agent in each boron nanoparticle. As the density of the thermal neutron beam remains low, it is unable to induce high-efficiency cell destruction. Herein, we report phospholipid-coated boronic oxide nanoparticles as agents for BNCT that can provide a highly concentrated boron atom in each nanoparticle. The current system exhibited in vitro BNCT activity seven times higher than that of commercial boron agents. Furthermore, the system could penetrate cancer spheroids deeply, efficiently suppressing thermal neutron irradiation-induced growth.

Identifiants

DOI: 10.1002/cbic.202300186 PMID: 37069129
pubmed: 37069129
doi: 10.1002/cbic.202300186
doi:

Substances chimiques

Boron N9E3X5056Q
Phospholipids 0
boron oxide 483W67CPF4
Boron Compounds 0
Oxides 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e202300186

Informations de copyright

© 2023 Wiley-VCH GmbH.

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Auteurs

Riku Kawasaki (R)

Program of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, 739-8527, Higashi-Hiroshima, Japan.
ORCID: 0000-0003-1621-8189

Hidetoshi Hirano (H)

Program of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, 739-8527, Higashi-Hiroshima, Japan.

Keita Yamana (K)

Program of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, 739-8527, Higashi-Hiroshima, Japan.

Ayano Oshige (A)

Program of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, 739-8527, Higashi-Hiroshima, Japan.

Kotaro Nishimura (K)

Program of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, 739-8527, Higashi-Hiroshima, Japan.

Nanami Kono (N)

Program of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, 739-8527, Higashi-Hiroshima, Japan.

Yu Sanada (Y)

Institute for Integrated Radiation and Nuclear Science, Kyoto University, Asashiro-Nishi, Kumatori-cho, 590-0494, Sennan-gun, Osaka, Japan.

Kaori Bando (K)

Department of Chemistry and Bioengineering Graduate School of Engineering, Osaka Metropolitan University, 3-3-138 Sugimoto, Sumiyoshi-ku, 558-8585, Osaka city, Japan.

Anri Tabata (A)

Department of Chemistry and Bioengineering Graduate School of Engineering, Osaka Metropolitan University, 3-3-138 Sugimoto, Sumiyoshi-ku, 558-8585, Osaka city, Japan.

Naoki Yasukawa (N)

Department of Chemistry and Bioengineering Graduate School of Engineering, Osaka Metropolitan University, 3-3-138 Sugimoto, Sumiyoshi-ku, 558-8585, Osaka city, Japan.

Hideki Azuma (H)

Department of Chemistry and Bioengineering Graduate School of Engineering, Osaka Metropolitan University, 3-3-138 Sugimoto, Sumiyoshi-ku, 558-8585, Osaka city, Japan.

Takushi Takata (T)

Institute for Integrated Radiation and Nuclear Science, Kyoto University, Asashiro-Nishi, Kumatori-cho, 590-0494, Sennan-gun, Osaka, Japan.

Yoshinori Sakurai (Y)

Institute for Integrated Radiation and Nuclear Science, Kyoto University, Asashiro-Nishi, Kumatori-cho, 590-0494, Sennan-gun, Osaka, Japan.

Hiroki Tanaka (H)

Institute for Integrated Radiation and Nuclear Science, Kyoto University, Asashiro-Nishi, Kumatori-cho, 590-0494, Sennan-gun, Osaka, Japan.

Minoru Suzuki (M)

Institute for Integrated Radiation and Nuclear Science, Kyoto University, Asashiro-Nishi, Kumatori-cho, 590-0494, Sennan-gun, Osaka, Japan.

Naoki Tarutani (N)

Program of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, 739-8527, Higashi-Hiroshima, Japan.

Kiyofumi Katagiri (K)

Program of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, 739-8527, Higashi-Hiroshima, Japan.

Takeshi Nagasaki (T)

Department of Chemistry and Bioengineering Graduate School of Engineering, Osaka Metropolitan University, 3-3-138 Sugimoto, Sumiyoshi-ku, 558-8585, Osaka city, Japan.

Atsushi Ikeda (A)

Program of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, 739-8527, Higashi-Hiroshima, Japan.

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Classifications MeSH

questionsmedicales.fr › Produits chimiques inorganiques › Éléments › Métalloïdes › Bore › Phospholipid-Coated Boronic Oxide...
questionsmedicales.fr › Lipides › Lipides membranaires › Phospholipides › Phospholipid-Coated Boronic Oxide...
questionsmedicales.fr › Thérapeutique › Radiothérapie › Radiothérapie de haute énergie › Thérapie par capture de neutrons › Thérapie par capture de neutrons par le bore › Phospholipid-Coated Boronic Oxide...
questionsmedicales.fr › Composés chimiques organiques › Composés du bore › Phospholipid-Coated Boronic Oxide...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Phospholipid-Coated Boronic Oxide...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Phospholipid-Coated Boronic Oxide...