Quantitative
Mycobacterium tuberculosis
antibiotic resistance
clinical trial
drug susceptibility test
nuclear magnetic resonance
pyrazinamide
tuberculosis
Journal
Journal of clinical microbiology
ISSN: 1098-660X
Titre abrégé: J Clin Microbiol
Pays: United States
ID NLM: 7505564
Informations de publication
Date de publication:
23 05 2023
23 05 2023
Historique:
medline:
25
5
2023
pubmed:
19
4
2023
entrez:
18
4
2023
Statut:
ppublish
Résumé
Tuberculosis (TB), caused by Mycobacterium tuberculosis, is one of the 10 leading killer diseases in the world. At least one-quarter of the population has been infected, and there are 1.3 million deaths annually. The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains challenges TB treatments. One of the drugs widely used in first- and second-line regimens is pyrazinamide (PZA). Statistically, 50% of MDR and 90% of XDR clinical strains are resistant to PZA, and recent studies have shown that its use in patients with PZA-resistant strains is associated with higher mortality rates. Therefore, the is an urgent need for the development of an accurate and efficient PZA susceptibility assay. PZA crosses the M. tuberculosis membrane and is hydrolyzed to its active form, pyrazinoic acid (POA), by a nicotinamidase encoded by the
Identifiants
pubmed: 37071032
doi: 10.1128/jcm.01522-22
pmc: PMC10204627
doi:
Substances chimiques
Pyrazinamide
2KNI5N06TI
Antitubercular Agents
0
Amidohydrolases
EC 3.5.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0152222Subventions
Organisme : Wellcome Trust (WT)
ID : 099805/Z/12/Z
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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