Epitope Mapping of Anti-Mouse CCR3 Monoclonal Antibodies (C

Animals Rats Receptors, CCR3 Antibodies, Monoclonal / metabolism Epitope Mapping Eosinophils / metabolism Colorectal Neoplasms Immunoglobulin G
alanine scanning epitope flow cytometry monoclonal antibody mouse CCR3

Journal

Monoclonal antibodies in immunodiagnosis and immunotherapy
ISSN: 2167-9436
Titre abrégé: Monoclon Antib Immunodiagn Immunother
Pays: United States
ID NLM: 101590955

Informations de publication

Date de publication:
Apr 2023
Historique:
medline: 3 5 2023
pubmed: 19 4 2023
entrez: 19 04 2023
Statut: ppublish

Résumé

One of G protein-coupled receptors, CC chemokine receptor 3 (CCR3), is expressed in eosinophils, basophils, a subset of Th2 lymphocytes, mast cells, and airway epithelial cells. CCR3 levels in the serum of colorectal cancer patients are significantly higher than in control groups. Moreover, CCR3 is essential for recruiting eosinophils into the lung. Therefore, CCR3 is considered both a therapeutic target for colorectal cancer and allergic diseases. Previously, we established anti-mouse CCR3 (mCCR3) monoclonal antibodies (mAbs), C

Identifiants

DOI: 10.1089/mab.2022.0034 PMID: 37074100
pubmed: 37074100
doi: 10.1089/mab.2022.0034
doi:

Substances chimiques

Receptors, CCR3 0
Antibodies, Monoclonal 0
Immunoglobulin G 0
Ccr3 protein, rat 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

68-72

Auteurs

Nami Tateyama (N)

Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Japan.

Teizo Asano (T)

Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Japan.

Tomohiro Tanaka (T)

Department of Molecular Pharmacology, and Tohoku University Graduate School of Medicine, Sendai, Japan.

Yu Isoda (Y)

Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Japan.

Yuki Okada (Y)

Department of Molecular Pharmacology, and Tohoku University Graduate School of Medicine, Sendai, Japan.

Hiyori Kobayashi (H)

Department of Molecular Pharmacology, and Tohoku University Graduate School of Medicine, Sendai, Japan.

Guanjie Li (G)

Department of Molecular Pharmacology, and Tohoku University Graduate School of Medicine, Sendai, Japan.

Ren Nanamiya (R)

Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Japan.

Takeo Yoshikawa (T)

Department of Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan.
ORCID: 0000-0002-7056-6021

Mika K Kaneko (MK)

Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Japan.
Department of Molecular Pharmacology, and Tohoku University Graduate School of Medicine, Sendai, Japan.

Hiroyuki Suzuki (H)

Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Japan.
Department of Molecular Pharmacology, and Tohoku University Graduate School of Medicine, Sendai, Japan.

Yukinari Kato (Y)

Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Japan.
Department of Molecular Pharmacology, and Tohoku University Graduate School of Medicine, Sendai, Japan.
Department of Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan.
ORCID: 0000-0001-5385-8201

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Epitope Mapping of Anti-Mouse CCR3 Monoclonal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Epitope Mapping of Anti-Mouse CCR3 Monoclonal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteurs aux chimiokines › Récepteurs CCR › Récepteurs CCR3 › Epitope Mapping of Anti-Mouse CCR3 Monoclonal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps monoclonaux › Epitope Mapping of Anti-Mouse CCR3 Monoclonal...
questionsmedicales.fr › Techniques d'investigation › Techniques de sonde moléculaire › Cartographie d'interactions entre protéines › Cartographie épitopique › Epitope Mapping of Anti-Mouse CCR3 Monoclonal...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Granulocytes › Granulocytes éosinophiles › Epitope Mapping of Anti-Mouse CCR3 Monoclonal...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du rectum › Tumeurs colorectales › Epitope Mapping of Anti-Mouse CCR3 Monoclonal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Isotypes des immunoglobulines › Immunoglobuline G › Epitope Mapping of Anti-Mouse CCR3 Monoclonal...