Deficiency of the CD155-CD96 immune checkpoint controls IL-9 production in giant cell arteritis.

Mice Animals Humans Giant Cell Arteritis / metabolism Cytokines / metabolism T-Lymphocytes Adaptive Immunity Antigens, CD / metabolism
CD155 CD96 ER stress IL-9 T cell autoimmune vasculitis autoimmunity giant cell arteritis immune checkpoint receptors macrophage

Journal

Cell reports. Medicine
ISSN: 2666-3791
Titre abrégé: Cell Rep Med
Pays: United States
ID NLM: 101766894

Informations de publication

Date de publication:
18 04 2023
Historique:
received: 24 10 2022
revised: 13 02 2023
accepted: 21 03 2023
medline: 21 4 2023
pubmed: 20 4 2023
entrez: 19 04 2023
Statut: ppublish

Résumé

Loss of function of inhibitory immune checkpoints, unleashing pathogenic immune responses, is a potential risk factor for autoimmune disease. Here, we report that patients with the autoimmune vasculitis giant cell arteritis (GCA) have a defective CD155-CD96 immune checkpoint. Macrophages from patients with GCA retain the checkpoint ligand CD155 in the endoplasmic reticulum (ER) and fail to bring it to the cell surface. CD155

Identifiants

DOI: 10.1016/j.xcrm.2023.101012 PMID: 37075705 PMC: PMC10140609
pubmed: 37075705
pii: S2666-3791(23)00122-2
doi: 10.1016/j.xcrm.2023.101012
pmc: PMC10140609
pii:
doi:

Substances chimiques

Cytokines 0
Antigens, CD 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

101012

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI108906
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR042527
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL117913
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL142068
Pays : United States

Informations de copyright

Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests K.J.W. has received clinical trial support from Eli Lilly, GSK, and Kiniksa; he received consulting fees and honoraria from Chemocentryx.

Références

JCI Insight. 2018 Oct 18;3(20):
pubmed: 30333306
Cell. 2010 Mar 19;140(6):900-17
pubmed: 20303879
J Immunol. 2000 Jun 1;164(11):5556-63
pubmed: 10820229
J Am Coll Cardiol. 2019 Apr 16;73(14):1811-1823
pubmed: 30975299
Eur J Immunol. 2020 Jun;50(6):891-902
pubmed: 32043568
Proc Natl Acad Sci U S A. 2003 May 13;100(10):5783-8
pubmed: 12724521
J Clin Invest. 2017 Jun 30;127(7):2725-2738
pubmed: 28604383
J Immunol. 2011 Feb 1;186(3):1338-42
pubmed: 21199897
Curr Opin Immunol. 2012 Apr;24(2):246-51
pubmed: 22285893
J Allergy Clin Immunol. 2000 Jan;105(1 Pt 1):108-15
pubmed: 10629460
Int Immunol. 2007 Jul;19(7):813-24
pubmed: 17606980
Cancer Cell. 2018 Jun 11;33(6):1048-1060.e7
pubmed: 29894691
Gut. 2015 May;64(5):743-55
pubmed: 24957265
Cell Mol Immunol. 2019 Jan;16(1):40-52
pubmed: 30275538
Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13175-80
pubmed: 9371819
Mod Pathol. 2017 Jun;30(6):788-796
pubmed: 28256573
Nat Rev Immunol. 2021 Jan;21(1):37-48
pubmed: 32788707
Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E970-E979
pubmed: 28115719
J Exp Med. 2004 Jan 19;199(2):173-83
pubmed: 14734523
Nature. 1990 Nov 8;348(6297):125-32
pubmed: 2122258
J Clin Invest. 2021 Jan 4;131(1):
pubmed: 32960812
PLoS One. 2013;8(1):e54406
pubmed: 23349877
Cardiovasc Res. 2015 Jun 1;106(3):453-64
pubmed: 25784693
Sci Rep. 2017 Sep 5;7(1):10445
pubmed: 28874810
J Clin Invest. 2015 May;125(5):2046-58
pubmed: 25866972
Circ Res. 2018 Aug 31;123(6):700-715
pubmed: 29970365
Nature. 2006 Aug 31;442(7106):997-1002
pubmed: 16921386
Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12885-90
pubmed: 19433802
Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):E2940-E2949
pubmed: 29531070
Nat Immunol. 2009 Jan;10(1):48-57
pubmed: 19011627
Circ Res. 2023 Jan 20;132(2):238-250
pubmed: 36656970
Nat Rev Dis Primers. 2022 Jan 6;7(1):93
pubmed: 34992251
Rheumatology (Oxford). 2015 Sep;54(9):1596-604
pubmed: 25862016
J Cell Biol. 2004 Oct 11;167(1):35-41
pubmed: 15466483
Oncogene. 2018 Sep;37(39):5269-5280
pubmed: 29855615
J Allergy Clin Immunol. 2000 Sep;106(3):460-6
pubmed: 10984364
Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17858-63
pubmed: 19815499
Circulation. 2011 Jan 25;123(3):309-18
pubmed: 21220737
J Exp Med. 2016 Mar 7;213(3):337-54
pubmed: 26926996
Annu Rev Immunol. 2016 May 20;34:539-73
pubmed: 26927206
Front Immunol. 2018 May 17;9:1072
pubmed: 29868026
Semin Immunopathol. 2017 Jan;39(1):11-20
pubmed: 27837254
Immunity. 1999 Oct;11(4):391-8
pubmed: 10549621
Biochem J. 2006 Nov 15;400(1):163-8
pubmed: 16842238
Nat Immunol. 2014 Jul;15(7):676-86
pubmed: 24908389
Arthritis Rheum. 1990 Aug;33(8):1122-8
pubmed: 2202311
Circulation. 2018 May 1;137(18):1934-1948
pubmed: 29254929
Immunity. 1996 Jun;4(6):573-81
pubmed: 8673704
Nat Med. 2012 Aug;18(8):1248-53
pubmed: 22772464
J Hematol Oncol. 2020 Jun 12;13(1):76
pubmed: 32532329
J Biol Chem. 2002 Mar 8;277(10):7897-904
pubmed: 11751937
Nat Cardiovasc Res. 2022 Jul;1(7):634-648
pubmed: 36860353
Arthritis Rheum. 2012 Jun;64(6):2001-11
pubmed: 22147555
J Exp Med. 2019 Jun 3;216(6):1244-1254
pubmed: 31068379
J Clin Invest. 2012 Nov;122(11):4160-71
pubmed: 23064366
Nat Immunol. 2014 May;15(5):431-8
pubmed: 24658051
Nat Rev Rheumatol. 2013 Dec;9(12):731-40
pubmed: 24189842
Immunol Rev. 2017 Mar;276(1):112-120
pubmed: 28258695
Nat Rev Dis Primers. 2020 May 7;6(1):38
pubmed: 32382051
J Exp Med. 2009 Aug 3;206(8):1653-60
pubmed: 19596803
Sci Transl Med. 2017 Jul 19;9(399):
pubmed: 28724574
Autoimmunity. 2009 Nov;42(7):596-604
pubmed: 19657775
J Exp Med. 2013 Dec 16;210(13):2951-65
pubmed: 24249111
J Cell Sci. 2009 May 15;122(Pt 10):1626-36
pubmed: 19420237

Auteurs

Shozo Ohtsuki (S)

Department of Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA; Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA; Department of Cardiology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA.

Chenyao Wang (C)

Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA; Department of Cardiology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA.

Ryu Watanabe (R)

Department of Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA; Department of Clinical Immunology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.

Hui Zhang (H)

Department of Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA; Deptartment of Rheumatology, Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangdong, China.

Mitsuhiro Akiyama (M)

Department of Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA; Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.

Melanie C Bois (MC)

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.

Joseph J Maleszewski (JJ)

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.

Kenneth J Warrington (KJ)

Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA.

Gerald J Berry (GJ)

Department of Pathology, School of Medicine, Stanford University, Stanford, CA 94305, USA.

Jörg J Goronzy (JJ)

Department of Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA; Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA.

Cornelia M Weyand (CM)

Department of Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA; Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA; Department of Cardiology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA; Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA. Electronic address: cweyand@stanford.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Deficiency of the CD155-CD96 immune checkpoint...
questionsmedicales.fr › Eucaryotes › Animaux › Deficiency of the CD155-CD96 immune checkpoint...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Deficiency of the CD155-CD96 immune checkpoint...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Maladies auto-immunes du système nerveux › Vascularite du système nerveux central › Artérite à cellules géantes › Deficiency of the CD155-CD96 immune checkpoint...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Deficiency of the CD155-CD96 immune checkpoint...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Deficiency of the CD155-CD96 immune checkpoint...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › Deficiency of the CD155-CD96 immune checkpoint...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes CD › Deficiency of the CD155-CD96 immune checkpoint...