Lower levels of cortical [

Humans Aged Pirenzepine Schizophrenia / metabolism Receptor, Muscarinic M1 / metabolism Cognition Disorders Cognition
Cortex Muscarinic M1 receptor Schizophrenia Sub-group Symptom ratings

Journal

Schizophrenia research
ISSN: 1573-2509
Titre abrégé: Schizophr Res
Pays: Netherlands
ID NLM: 8804207

Informations de publication

Date de publication:
05 2023
Historique:
received: 07 07 2022
revised: 15 02 2023
accepted: 18 03 2023
medline: 15 5 2023
pubmed: 20 4 2023
entrez: 20 04 2023
Statut: ppublish

Résumé

Multiple lines of evidence argue for lower levels of cortical muscarinic M1 receptors (CHRM1) in people with schizophrenia which is possibly due to a sub-group within the disorder who have a marked loss of CHRM1 (muscarinic receptor deficit sub-group (MRDS)). In this study we sought to determine if the lower levels of CHRM1 was apparent in older people with schizophrenia and whether the loss of CHRM1 was associated with symptom severity by measuring levels of cortical [

Identifiants

DOI: 10.1016/j.schres.2023.03.035 PMID: 37079947
pubmed: 37079947
pii: S0920-9964(23)00129-9
doi: 10.1016/j.schres.2023.03.035
pii:
doi:

Substances chimiques

Pirenzepine 3G0285N20N
Receptor, Muscarinic M1 0
CHRM1 protein, human 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

274-282

Informations de copyright

Copyright © 2023 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest BD, VF and ES have no conflicts of interest.

Auteurs

Brian Dean (B)

The Synaptic Biology and Cognition Laboratory, The Florey Institute for Neuroscience and Mental Health, Parkville, Victoria, Australia; Florey Department of Neuroscience and Mental Health, the University of Melbourne, Parkville, Victoria, Australia. Electronic address: brian.dean@florey.edu.au.

Vahram Haroutunian (V)

Departments of Psychiatry and Neuroscience, The Icahn School of Medicine at Mount Sinai, New York, NY, USA; The Mental Illness Research, Education and Clinical Centers, JJ Peters VA Medical Center, Bronx, NY, USA.

Elizabeth Scarr (E)

Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, Australia.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Lower levels of cortical [
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Lower levels of cortical [
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzazépines › Benzodiazépines › Benzodiazépinones › Pirenzépine › Lower levels of cortical [
questionsmedicales.fr › Troubles mentaux › Schizophrénie et troubles avec traits psychotiques › Schizophrénie › Lower levels of cortical [
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs cholinergiques › Récepteur muscarinique › Récepteur muscarinique de type M1 › Lower levels of cortical [
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Lower levels of cortical [
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Cognition › Lower levels of cortical [