A comparative study on the metal complexes of an anticancer estradiol-hydroxamate conjugate and salicylhydroxamic acid.
Copper
Cytotoxicity
Iron
Organometallic complexes
Solution speciation
Sterane
Journal
Journal of inorganic biochemistry
ISSN: 1873-3344
Titre abrégé: J Inorg Biochem
Pays: United States
ID NLM: 7905788
Informations de publication
Date de publication:
07 2023
07 2023
Historique:
received:
02
03
2023
revised:
03
04
2023
accepted:
10
04
2023
medline:
10
5
2023
pubmed:
22
4
2023
entrez:
21
04
2023
Statut:
ppublish
Résumé
Hydroxamic acids bearing an (O,O) donor set are well-known metal-chelating compounds with diverse biological activities including anticancer activity. Since steroid conjugation with a pharmacophoric moiety may have the potential to improve this effect, a salicylhydroxamic acid-estradiol hybrid molecule (E2HA) was synthesized. Only minimal effect of the conjugation on the proton dissociation constants was observed in comparison to salicylhydroxamic acid (SHA). The complexation with essential metal ions (iron, copper) was characterized, since E2HA may exert its cytotoxicity through the binding of these ions in cells. UV-visible spectrophotometric and pH-potentiometric titrations revealed the formation of high-stability complexes, while the Fe(III) preference over Fe(II) was proved by cyclic voltammetry and spectroelectrochemical measurements. Complex formation with half-sandwich Rh(III)(η
Identifiants
pubmed: 37084580
pii: S0162-0134(23)00105-8
doi: 10.1016/j.jinorgbio.2023.112223
pii:
doi:
Substances chimiques
Coordination Complexes
0
salicylhydroxamic acid
8Q07182D0T
Ligands
0
Estradiol
4TI98Z838E
Ferric Compounds
0
Antineoplastic Agents
0
Ions
0
Hydroxamic Acids
0
Ruthenium
7UI0TKC3U5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
112223Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Eva A. Enyedy reports financial support was provided by National Research Development and Innovation Office. Eva A. Enyedy reports financial support was provided by Eötvös Loránd Research Network.