A detailed genome-scale metabolic model of Clostridium thermocellum investigates sources of pyrophosphate for driving glycolysis.

Clostridium thermocellum / genetics Diphosphates / metabolism Glycolysis / genetics Fermentation Adenosine Triphosphate / metabolism
Bioprocessing Clostridium thermocellum Glycolysis Metabolism Modeling Pyrophosphate

Journal

Metabolic engineering
ISSN: 1096-7184
Titre abrégé: Metab Eng
Pays: Belgium
ID NLM: 9815657

Informations de publication

Date de publication:
05 2023
Historique:
received: 26 01 2023
revised: 24 03 2023
accepted: 08 04 2023
medline: 16 5 2023
pubmed: 22 4 2023
entrez: 21 04 2023
Statut: ppublish

Résumé

Lignocellulosic biomass is an abundant and renewable source of carbon for chemical manufacturing, yet it is cumbersome in conventional processes. A promising, and increasingly studied, candidate for lignocellulose bioprocessing is the thermophilic anaerobe Clostridium thermocellum given its potential to produce ethanol, organic acids, and hydrogen gas from lignocellulosic biomass under high substrate loading. Possessing an atypical glycolytic pathway which substitutes GTP or pyrophosphate (PP

Identifiants

DOI: 10.1016/j.ymben.2023.04.003 PMID: 37085141
pubmed: 37085141
pii: S1096-7176(23)00055-1
doi: 10.1016/j.ymben.2023.04.003
pii:
doi:

Substances chimiques

diphosphoric acid 4E862E7GRQ
Diphosphates 0
Adenosine Triphosphate 8L70Q75FXE

Types de publication

Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

306-322

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Wheaton L Schroeder (WL)

Department of Chemical Engineering, The Pennsylvania State University, University Park, PA, USA; Center for Bioenergy Innovation, Oak Ridge, TN, USA.

Teun Kuil (T)

Department of Industrial Biotechnology, School of Engineering Sciences in Chemistry Biotechnology and Health, KTH Royal Institute of Technology, Stockholm, Sweden.

Antonius J A van Maris (AJA)

Department of Industrial Biotechnology, School of Engineering Sciences in Chemistry Biotechnology and Health, KTH Royal Institute of Technology, Stockholm, Sweden.

Daniel G Olson (DG)

Center for Bioenergy Innovation, Oak Ridge, TN, USA; Thayer School of Engineering, Dartmouth College, Hanover, NH, USA.

Lee R Lynd (LR)

Center for Bioenergy Innovation, Oak Ridge, TN, USA; Thayer School of Engineering, Dartmouth College, Hanover, NH, USA.

Costas D Maranas (CD)

Department of Chemical Engineering, The Pennsylvania State University, University Park, PA, USA; Center for Bioenergy Innovation, Oak Ridge, TN, USA. Electronic address: costas@psu.edu.

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Classifications MeSH

questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bactéries à Gram positif formant des endospores › Clostridium › Clostridium thermocellum › A detailed genome-scale metabolic model of...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du phosphore › Acides du phosphore › Acides phosphoriques › Phosphates › Polyphosphates › Diphosphates › A detailed genome-scale metabolic model of...
questionsmedicales.fr › Métabolisme › Voies et réseaux métaboliques › Glycolyse › A detailed genome-scale metabolic model of...
questionsmedicales.fr › Métabolisme › Métabolisme glucidique › Fermentation › A detailed genome-scale metabolic model of...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › Adénosine triphosphate › A detailed genome-scale metabolic model of...