Metabolic engineering of

Corynebacterium glutamicum / metabolism Metabolic Engineering / methods Dicarboxylic Acids / metabolism Pyridines / metabolism Pyrones / metabolism Fermentation Glucose / metabolism
Corynebacterium glutamicum fed-batch fermentation pseudoaromatic dicarboxylic acid sustainability systems metabolic engineering

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
05 Nov 2024
Historique:
medline: 31 10 2024
pubmed: 30 10 2024
entrez: 30 10 2024
Statut: ppublish

Résumé

Environmental concerns from plastic waste are driving interest in alternative monomers from bio-based sources. Pseudoaromatic dicarboxylic acids are promising alternatives with chemical structures similar to widely used petroleum-based aromatic dicarboxylic acids. However, their use in polyester synthesis has been limited due to production challenges. Here, we report the fermentative production of five pseudoaromatic dicarboxylic acids, including 2-pyrone-4,6-dicarboxylic acid (PDC) and pyridine dicarboxylic acids (PDCAs: 2,3-, 2,4-, 2,5-, and 2,6-PDCA), from glucose using five engineered

Identifiants

DOI: 10.1073/pnas.2415213121 PMID: 39475655
pubmed: 39475655
doi: 10.1073/pnas.2415213121
doi:

Substances chimiques

Dicarboxylic Acids 0
Pyridines 0
Pyrones 0
Glucose IY9XDZ35W2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2415213121

Subventions

Organisme : Ministry of Science and ICT, South Korea (MSIT)
ID : 2022M3J5A1056072
Organisme : Ministry of Science and ICT, South Korea (MSIT)
ID : 2022M3J5A1056117

Déclaration de conflit d'intérêts

Competing interests statement:We disclose that S.Y.L. and one of the reviewers, P.I.N., had co-authored an editorial (https://pubmed.ncbi.nlm.nih.gov/38801001/).

Auteurs

Jae Sung Cho (JS)

Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 Four Program), Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
BioProcess Engineering Research Center, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.

Zi Wei Luo (ZW)

Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 Four Program), Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
BioProcess Engineering Research Center, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
ORCID: 0000-0001-6018-9368

Cheon Woo Moon (CW)

Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 Four Program), Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
BioProcess Engineering Research Center, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
ORCID: 0000-0002-6450-1328

Cindy Pricilia Surya Prabowo (CPS)

Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 Four Program), Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
BioProcess Engineering Research Center, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.

Sang Yup Lee (SY)

Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 Four Program), Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
BioProcess Engineering Research Center, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
Graduate School of Engineering Biology, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
ORCID: 0000-0003-0599-3091

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Classifications MeSH

questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes irréguliers à Gram positif › Corynebacterium › Corynebacterium glutamicum › Metabolic engineering of
questionsmedicales.fr › Technologie, industrie et agriculture › Ingénierie › Bioingénierie › Ingénierie cellulaire › Génie métabolique › Metabolic engineering of
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides acycliques › Diacides carboxyliques › Metabolic engineering of
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Metabolic engineering of
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrannes › Pyrones › Metabolic engineering of
questionsmedicales.fr › Métabolisme › Métabolisme glucidique › Fermentation › Metabolic engineering of
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Metabolic engineering of