Clonally expanded PD-1-expressing T cells are enriched in synovial fluid of juvenile idiopathic arthritis patients.
Immune checkpoints ⋅ Inflammation ⋅ Juvenile Idiopathic Arthritis ⋅ T cells ⋅ PD-1
Journal
European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201
Informations de publication
Date de publication:
Jul 2023
Jul 2023
Historique:
revised:
23
03
2023
received:
30
08
2022
accepted:
17
04
2023
medline:
17
7
2023
pubmed:
22
4
2023
entrez:
22
04
2023
Statut:
ppublish
Résumé
Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic condition in childhood. The disease etiology remains largely unknown; however, a key role in JIA pathogenesis is surely mediated by T cells. T-lymphocytes activity is controlled via signals, known as immune checkpoints. Delivering an inhibitory signal or blocking a stimulatory signal to achieve immune suppression is critical in autoimmune diseases. However, the role of immune checkpoints in chronic inflammation and autoimmunity must still be deciphered. In this study, we investigated at the single-cell level the feature of T cells in JIA chronic inflammation, both at the transcriptome level via single-cell RNA sequencing and at the protein level by flow cytometry. We found that despite the heterogeneity in the composition of synovial CD4
Identifiants
pubmed: 37086046
doi: 10.1002/eji.202250162
doi:
Substances chimiques
Programmed Cell Death 1 Receptor
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2250162Subventions
Organisme : Department of Experimental and Clinical Medicine of University of Florence
Informations de copyright
© 2023 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.
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