New perspectives on the basal forebrain cholinergic system in Alzheimer's disease.
Acetylcholine
Amyloid
Attention
Basal forebrain
Learning
Memory
Reserve
Resilience
Tau
Journal
Neuroscience and biobehavioral reviews
ISSN: 1873-7528
Titre abrégé: Neurosci Biobehav Rev
Pays: United States
ID NLM: 7806090
Informations de publication
Date de publication:
07 2023
07 2023
Historique:
received:
23
12
2022
revised:
27
02
2023
accepted:
28
03
2023
pmc-release:
01
07
2024
medline:
5
6
2023
pubmed:
23
4
2023
entrez:
22
04
2023
Statut:
ppublish
Résumé
The basal forebrain cholinergic system (BFCS) has long been implicated in age-related cognitive changes and the pathophysiology of Alzheimer's disease (AD). Limitations of cholinergic interventions helped to inspire a shift away from BFCS in AD research. A resurgence in interest in the BFCS following methodological and analytical advances has resulted in a call for the BFCS to be examined in novel frameworks. We outline the basic structure and function of the BFCS, its role in supporting cognitive and affective function, and its vulnerability to aging and AD. We consider the BFCS in the context of the amyloid hypothesis and evolving concepts in AD research: resilience and resistance to pathology, selective neuronal vulnerability, trans-synaptic pathology spread and sleep health. We highlight 1) the potential role of the BFCS in cognitive resilience, 2) recent work refining understanding about the selective vulnerability of BFCS to AD, 3) BFCS connectivity that suggests it is related to tau spreading and neurodegeneration and 4) the gap between BFCS involvement in AD and sleep-wake cycles.
Identifiants
pubmed: 37086935
pii: S0149-7634(23)00161-6
doi: 10.1016/j.neubiorev.2023.105192
pmc: PMC10249144
mid: NIHMS1897642
pii:
doi:
Substances chimiques
Cholinergic Agents
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
105192Subventions
Organisme : NIA NIH HHS
ID : K01 AG078443
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG074330
Pays : United States
Organisme : NIA NIH HHS
ID : R03 AG067033
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Competing Interests The authors have no competing interests to declare.
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