α1-Adrenergic Stimulation Increases Platelet Adhesion to Endothelial Cells Mediated by TRPC6.
Calcium
Endothelial cells
Platelet adhesion
TRPC6
α1-adrenergic receptor
Journal
Advances in experimental medicine and biology
ISSN: 0065-2598
Titre abrégé: Adv Exp Med Biol
Pays: United States
ID NLM: 0121103
Informations de publication
Date de publication:
2023
2023
Historique:
medline:
26
4
2023
pubmed:
24
4
2023
entrez:
24
04
2023
Statut:
ppublish
Résumé
Stimulation of a1-adrenergic nervous system is increased during systemic inflammation and other pathological conditions with the consequent adrenergic receptors (ARs) activation. It has been reported that a1-stimulation contributes to coagulation since a1-AR blockers inhibit coagulation and its organic consequences. Also, coagulation induced by a1-AR stimulation can be greatly decreased using a1-AR blockers. In health, endothelial cells (ECs) perform anticoagulant actions at cellular and molecular level. However, during inflammation, ECs turn dysfunctional promoting a procoagulant state. Endothelium-dependent coagulation progresses at cellular and molecular levels, promoting endothelial acquisition of procoagulant properties to potentiate coagulation by means of prothrombotic and antifibrinolytic proteins expression increase in ECs releasing them to circulation, the thrombus formation is strengthened. Calcium signaling is a main feature of coagulation. Inhibition of ion channels involved in Ca
Identifiants
pubmed: 37093422
doi: 10.1007/978-3-031-26163-3_4
doi:
Substances chimiques
TRPC6 Cation Channel
0
TRPC Cation Channels
0
Adrenergic Agents
0
Calcium
SY7Q814VUP
Trpc6 protein, rat
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
65-82Informations de copyright
© 2023. The Author(s), under exclusive license to Springer Nature Switzerland AG.
Références
Alzahrani SH, Ajjan RA (2010) Coagulation and fibrinolysis in diabetes. Diab Vasc Dis Res 7(4):260–273
pubmed: 20847109
doi: 10.1177/1479164110383723
Duburcq T, Tournoys A, Gnemmi V, Hubert T, Gmyr V, Pattou F et al (2015) Impact of obesity on endotoxin-induced disseminated intravascular coagulation. Shock 44(4):341–347
pubmed: 26125085
doi: 10.1097/SHK.0000000000000428
Gavras I, Gavras H (2004) Hypertension, vasoactive peptides and coagulation factors. J Hypertens 22(6):1091–1092
pubmed: 15167441
doi: 10.1097/00004872-200406000-00007
Gupta D, Molina EJ, Palma J, Gaughan JP, Long W, Macha M (2008) Adenoviral beta-adrenergic receptor kinase inhibitor gene transfer improves exercise capacity, cardiac contractility, and systemic inflammation in a model of pressure overload hypertrophy. Cardiovasc Drugs Ther 22(5):373–381
pubmed: 18690529
doi: 10.1007/s10557-008-6123-x
Hess K (2015) The vulnerable blood. Coagulation and clot structure in diabetes mellitus. Hamostaseologie 35(1):25–33
Lallukka S, Luukkonen PK, Zhou Y, Isokuortti E, Leivonen M, Juuti A et al (2017) Obesity/insulin resistance rather than liver fat increases coagulation factor activities and expression in humans. Thromb Haemost 117(2):286–294
pubmed: 27929200
doi: 10.1160/TH16-09-0716
Moriau M, Noel H, Masure R (1974) Effects of alpha and beta receptor stimulating and blocking agents on experimental disseminated intravascular coagulation. Thromb Diath Haemorrh 32(1):157–170
pubmed: 4156098
Schmitz D, Wilsenack K, Lendemanns S, Schedlowski M, Oberbeck R (2007) beta-Adrenergic blockade during systemic inflammation: impact on cellular immune functions and survival in a murine model of sepsis. Resuscitation 72(2):286–294
pubmed: 17118511
doi: 10.1016/j.resuscitation.2006.07.001
Schouten M, Wiersinga WJ, Levi M, van der Poll T (2008) Inflammation, endothelium, and coagulation in sepsis. J Leukoc Biol 83(3):536–545
pubmed: 18032692
doi: 10.1189/jlb.0607373
von Kanel R, Dimsdale JE (2000) Effects of sympathetic activation by adrenergic infusions on hemostasis in vivo. Eur J Haematol 65(6):357–369
doi: 10.1034/j.1600-0609.2000.065006357.x
von Kanel R, Dimsdale JE, Adler KA, Dillon E, Perez CJ, Mills PJ (2003) Effects of nonspecific beta-adrenergic stimulation and blockade on blood coagulation in hypertension. J Appl Physiol 94(4):1455–1459
Lymperopoulos A, Rengo G, Koch WJ (2013) Adrenergic nervous system in heart failure: pathophysiology and therapy. Circ Res 113(6):739–753
Pupo AS, Minneman KP (2001) Adrenergic pharmacology: focus on the central nervous system. CNS Spectr 6(8):656–662
pubmed: 15520613
doi: 10.1017/S1092852900001346
Motiejunaite J, Amar L, Vidal-Petiot E (2021) Adrenergic receptors and cardiovascular effects of catecholamines. Ann Endocrinol (Paris) 82(3–4):193–197
Campbell AP, Smrcka AV (2018) Targeting G protein-coupled receptor signalling by blocking G proteins. Nat Rev Drug Discov 17(11):789–803
pubmed: 30262890
pmcid: 6409483
doi: 10.1038/nrd.2018.135
Ghanemi A, Hu X (2015) Elements toward novel therapeutic targeting of the adrenergic system. Neuropeptides 49:25–35
pubmed: 25481798
doi: 10.1016/j.npep.2014.11.003
Latour JG, Leger-Gauthier C, Solymoss BC (1985) Vasoactive agents and production of thrombosis during intravascular coagulation. 2. alpha-Adrenergic stimulation: effects and mechanisms. Pathology 17(3):429–436
Nossent AY, Dai L, Rosendaal FR, Vos HL, Eikenboom JC (2005) Beta 2 adrenergic receptor polymorphisms: association with factor VIII and von Willebrand factor levels and the risk of venous thrombosis. J Thromb Haemost 3(2):405–407
pubmed: 15670061
doi: 10.1111/j.1538-7836.2005.01109.x
Zee RY, Cook NR, Cheng S, Erlich HA, Lindpaintner K, Ridker PM (2006) Polymorphism in the beta2-adrenergic receptor and lipoprotein lipase genes as risk determinants for idiopathic venous thromboembolism: a multilocus, population-based, prospective genetic analysis. Circulation 113(18):2193–2200
pubmed: 16651467
doi: 10.1161/CIRCULATIONAHA.106.615401
Alan C, Kirilmaz B, Kocoglu H, Ersay AR, Ertung Y, Eren AE (2011) Comparison of effects of alpha receptor blockers on endothelial functions and coagulation parameters in patients with benign prostatic hyperplasia. Urology 77(6):1439–1443
pubmed: 21256572
doi: 10.1016/j.urology.2010.10.019
Nowak G, Markwardt F (1981) The influence of drugs on disseminated intravascular coagulation (DIC). V. Effects of alpha-adrenoceptor blocking agents on thrombin-induced DIC in rats. Thromb Res 22(4):417–425
Authi KS (2007) TRP channels in platelet function. Handb Exp Pharmacol 179:425–443
doi: 10.1007/978-3-540-34891-7_25
Chiarella SE, Soberanes S, Urich D, Morales-Nebreda L, Nigdelioglu R, Green D et al (2014) beta(2)-Adrenergic agonists augment air pollution-induced IL-6 release and thrombosis. J Clin Invest 124(7):2935–2946
Jimenez I, Prado Y, Marchant F, Otero C, Eltit F, Cabello-Verrugio C et al (2020) TRPM channels in human diseases. Cells 9(12):2604
von Kanel R, Mills PJ, Ziegler MG, Dimsdale JE (2002) Effect of beta2-adrenergic receptor functioning and increased norepinephrine on the hypercoagulable state with mental stress. Am Heart J 144(1):68–72
doi: 10.1067/mhj.2002.123146
Corrall RJ, Webber RJ, Frier BM (1980) Increase in coagulation factor VIII activity in man following acute hypoglycaemia: mediation via an adrenergic mechanism. Br J Haematol 44(2):301–305
pubmed: 6769459
doi: 10.1111/j.1365-2141.1980.tb01212.x
Rammer L, Stahl E (1979) Effect of beta-adrenergic blockade by propranolol upon intravascular coagulation in the rat kidney. Nephron 24(5):246–249
pubmed: 503267
doi: 10.1159/000181725
Gale AJ (2011) Continuing education course #2: current understanding of hemostasis. Toxicol Pathol 39(1):273–280
pubmed: 21119054
doi: 10.1177/0192623310389474
Gaertner F, Massberg S (2016) Blood coagulation in immunothrombosis—at the frontline of intravascular immunity. Semin Immunol 28(6):561–569
pubmed: 27866916
doi: 10.1016/j.smim.2016.10.010
Monagle P, Massicotte P (2011) Developmental haemostasis: secondary haemostasis. Semin Fetal Neonatal Med 16(6):294–300
pubmed: 21872543
doi: 10.1016/j.siny.2011.07.007
Le Hiress M, Tu L, Ricard N, Phan C, Thuillet R, Fadel E et al (2015) Proinflammatory signature of the dysfunctional endothelium in pulmonary hypertension. Role of the macrophage migration inhibitory factor/CD74 complex. Am J Respir Crit Care Med 192(8):983–997
Lupu F, Kinasewitz G, Dormer K (2020) The role of endothelial shear stress on haemodynamics, inflammation, coagulation and glycocalyx during sepsis. J Cell Mol Med 24(21):12258–12271
pubmed: 32951280
pmcid: 7687012
doi: 10.1111/jcmm.15895
Boos CJ, Goon PK, Lip GY (2006) The endothelium, inflammation, and coagulation in sepsis. Clin Pharmacol Ther 79(1):20–22
pubmed: 16413238
doi: 10.1016/j.clpt.2005.10.004
Chu AJ (2011) Tissue factor, blood coagulation, and beyond: an overview. Int J Inflam 2011:367284
pubmed: 21941675
pmcid: 3176495
Ito T, Kakihana Y, Maruyama I (2016) Thrombomodulin as an intravascular safeguard against inflammatory and thrombotic diseases. Expert Opin Ther Targets 20(2):151–158
pubmed: 26558419
doi: 10.1517/14728222.2016.1086750
Maroney SA, Mast AE (2008) Expression of tissue factor pathway inhibitor by endothelial cells and platelets. Transfus Apher Sci 38(1):9–14
pubmed: 18261960
pmcid: 2408687
doi: 10.1016/j.transci.2007.12.001
Akol H, Boon E, van Haren F, van der Hoeven J (2002) Successful treatment of fulminant pneumococcal sepsis with recombinant tissue plasminogen activator. Eur J Intern Med 13(6):389
pubmed: 12225785
doi: 10.1016/S0953-6205(02)00095-X
Benarroch EE (2007) Tissue plasminogen activator: beyond thrombolysis. Neurology 69(8):799–802
pubmed: 17709713
doi: 10.1212/01.wnl.0000269668.08747.78
Castellino FJ, Donahue DL, Navari RM, Ploplis VA, Walsh M (2011) An accompanying genetic severe deficiency of tissue factor protects mice with a protein C deficiency from lethal endotoxemia. Blood 117(1):283–289
pubmed: 20858853
pmcid: 3037749
doi: 10.1182/blood-2010-07-299057
Cesarman-Maus G, Hajjar KA (2005) Molecular mechanisms of fibrinolysis. Br J Haematol 129(3):307–321
Renckens R, Roelofs JJ, de Waard V, Florquin S, Lijnen HR, Carmeliet P et al (2005) The role of plasminogen activator inhibitor type 1 in the inflammatory response to local tissue injury. J Thromb Haemost 3(5):1018–1025
pubmed: 15869599
doi: 10.1111/j.1538-7836.2005.01311.x
Urano T, Suzuki Y (2012) Accelerated fibrinolysis and its propagation on vascular endothelial cells by secreted and retained tPA. J Biomed Biotechnol 2012:208108
pubmed: 23118500
pmcid: 3478939
doi: 10.1155/2012/208108
Kunicki TJ (2001) The role of platelet collagen receptor (glycoprotein Ia/IIa; integrin alpha2 beta1) polymorphisms in thrombotic disease. Curr Opin Hematol 8(5):277–285
pubmed: 11604562
doi: 10.1097/00062752-200109000-00003
Monnet E, Sizaret P, Arbeille B, Fauvel-Lafeve F (2000) Different role of platelet glycoprotein GP Ia/IIa in platelet contact and activation induced by type I and type III collagens. Thromb Res 98(5):423–433
pubmed: 10828482
doi: 10.1016/S0049-3848(00)00199-7
Swystun LL, Georgescu I, Mewburn J, Deforest M, Nesbitt K, Hebert K et al (2017) Abnormal von Willebrand factor secretion, factor VIII stabilization and thrombus dynamics in type 2N von Willebrand disease mice. J Thromb Haemost 15(8):1607–1619
pubmed: 28581694
doi: 10.1111/jth.13749
Xu ER, von Bulow S, Chen PC, Lenting PJ, Kolsek K, Aponte-Santamaria C et al (2019) Structure and dynamics of the platelet integrin-binding C4 domain of von Willebrand factor. Blood 133(4):366–376
pubmed: 30305279
pmcid: 6450055
doi: 10.1182/blood-2018-04-843615
Ridker PM, Buring JE, Rifai N (2001) Soluble P-selectin and the risk of future cardiovascular events. Circulation 103(4):491–495
pubmed: 11157711
doi: 10.1161/01.CIR.103.4.491
Secor D, Li F, Ellis CG, Sharpe MD, Gross PL, Wilson JX et al (2010) Impaired microvascular perfusion in sepsis requires activated coagulation and P-selectin-mediated platelet adhesion in capillaries. Intensive Care Med 36(11):1928–1934
pubmed: 20689935
pmcid: 3047470
doi: 10.1007/s00134-010-1969-3
Secor D, Swarbreck S, Ellis CG, Sharpe MD, Tyml K (2013) Ascorbate reduces mouse platelet aggregation and surface P-selectin expression in an ex vivo model of sepsis. Microcirculation 20(6):502–510
pubmed: 23402318
doi: 10.1111/micc.12047
Gawaz M, Neumann FJ, Dickfeld T, Reininger A, Adelsberger H, Gebhardt A et al (1997) Vitronectin receptor (alpha(v)beta3) mediates platelet adhesion to the luminal aspect of endothelial cells: implications for reperfusion in acute myocardial infarction. Circulation 96(6):1809–1818
pubmed: 9323066
doi: 10.1161/01.CIR.96.6.1809
Ward PA (2012) Inflammation and alphavbeta3 integrin. Am J Respir Crit Care Med 185(1):5–6
pubmed: 22210783
doi: 10.1164/rccm.201110-1859ED
Bristow SM, Gamble GD, Stewart A, Horne AM, Reid IR (2015) Acute effects of calcium supplements on blood pressure and blood coagulation: secondary analysis of a randomised controlled trial in post-menopausal women. Br J Nutr 114(11):1868–1874
pubmed: 26420590
doi: 10.1017/S0007114515003694
Davis CC, Edwards M (2017) Role of calcium in the coagulation of NOM with ferric chloride. Environ Sci Technol 51(20):11652–11659
pubmed: 28937218
doi: 10.1021/acs.est.7b02038
Fang X, Chen C, Wang Q, Gu J, Chi C (2001) The interaction of the calcium- and integrin-binding protein (CIBP) with the coagulation factor VIII. Thromb Res 102(2):177–185
pubmed: 11323029
doi: 10.1016/S0049-3848(01)00229-8
Stenflo J, Stenberg Y, Muranyi A (2000) Calcium-binding EGF-like modules in coagulation proteinases: function of the calcium ion in module interactions. Biochim Biophys Acta 1477(1–2):51–63
pubmed: 10708848
doi: 10.1016/S0167-4838(99)00262-9
Greer IA (1987) Therapeutic progress—review XXVIII. Platelet function and calcium channel blocking agents. J Clin Pharm Ther 12(4):213–222
Horner S, Menke K, Hildebrandt C, Kassack MU, Nickel P, Ullmann H et al (2005) The novel suramin analogue NF864 selectively blocks P2X1 receptors in human platelets with potency in the low nanomolar range. Naunyn Schmiedebergs Arch Pharmacol 372(1):1–13
pubmed: 16158305
doi: 10.1007/s00210-005-1085-z
Kelly CR, Dickinson CD, Ruf W (1997) Ca
pubmed: 9211891
doi: 10.1074/jbc.272.28.17467
Koklic T, Majumder R, Lentz BR (2014) Ca
pubmed: 24920080
doi: 10.1042/BJ20140130
Kumar R, Singh N, Singh K, Kalhan A, Prasad KK (2004) Recent insights on biochemical and molecular basis for developing antihaemostatic agents: a review. Indian J Clin Biochem 19(1):122–128
pubmed: 23105443
pmcid: 3453905
doi: 10.1007/BF02872406
Ohkubo YZ, Tajkhorshid E (2008) Distinct structural and adhesive roles of Ca
pubmed: 18184585
doi: 10.1016/j.str.2007.10.021
Dietrich A, Gudermann T (2007) Trpc6. Handb Exp Pharmacol 179:125–141
doi: 10.1007/978-3-540-34891-7_7
Shi J, Mori E, Mori Y, Mori M, Li J, Ito Y et al (2004) Multiple regulation by calcium of murine homologues of transient receptor potential proteins TRPC6 and TRPC7 expressed in HEK293 cells. J Physiol 561(Pt 2):415–432
pubmed: 15579537
pmcid: 1665365
doi: 10.1113/jphysiol.2004.075051
Hofmann T, Obukhov AG, Schaefer M, Harteneck C, Gudermann T, Schultz G (1999) Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature 397(6716):259–263
pubmed: 9930701
doi: 10.1038/16711
Yip H, Chan WY, Leung PC, Kwan HY, Liu C, Huang Y et al (2004) Expression of TRPC homologs in endothelial cells and smooth muscle layers of human arteries. Histochem Cell Biol 122(6):553–561
pubmed: 15538613
doi: 10.1007/s00418-004-0720-y
Earley S, Brayden JE (2015) Transient receptor potential channels in the vasculature. Physiol Rev 95(2):645–690
pubmed: 25834234
pmcid: 4551213
doi: 10.1152/physrev.00026.2014
Nilius B, Owsianik G (2010) Transient receptor potential channelopathies. Pflugers Arch 460(2):437–450
pubmed: 20127491
doi: 10.1007/s00424-010-0788-2
Dietrich A, Kalwa H, Rost BR, Gudermann T (2005) The diacylgylcerol-sensitive TRPC3/6/7 subfamily of cation channels: functional characterization and physiological relevance. Pflugers Arch 451(1):72–80
pubmed: 15971081
doi: 10.1007/s00424-005-1460-0
Kalwa H, Storch U, Demleitner J, Fiedler S, Mayer T, Kannler M et al (2015) Phospholipase C epsilon (PLCepsilon) induced TRPC6 activation: a common but redundant mechanism in primary podocytes. J Cell Physiol 230(6):1389–1399
pubmed: 25521631
pmcid: 4811033
doi: 10.1002/jcp.24883
Cayouette S, Lussier MP, Mathieu EL, Bousquet SM, Boulay G (2004) Exocytotic insertion of TRPC6 channel into the plasma membrane upon Gq protein-coupled receptor activation. J Biol Chem 279(8):7241–7246
pubmed: 14662757
doi: 10.1074/jbc.M312042200
Suzuki F, Morishima S, Tanaka T, Muramatsu I (2007) Snapin, a new regulator of receptor signaling, augments alpha1A-adrenoceptor-operated calcium influx through TRPC6. J Biol Chem 282(40):29563–29573
pubmed: 17684020
doi: 10.1074/jbc.M702063200
Hill AJ, Hinton JM, Cheng H, Gao Z, Bates DO, Hancox JC et al (2006) A TRPC-like non-selective cation current activated by alpha 1-adrenoceptors in rat mesenteric artery smooth muscle cells. Cell Calcium 40(1):29–40
pubmed: 16697039
doi: 10.1016/j.ceca.2006.03.007
Kong F, Ma L, Zou L, Meng K, Ji T, Zhang L et al (2015) Alpha1-adrenergic receptor activation stimulates calcium entry and proliferation via TRPC6 channels in cultured human mesangial cells. Cell Physiol Biochem 36(5):1928–1938
pubmed: 26202353
doi: 10.1159/000430161
Bousquet SM, Monet M, Boulay G (2010) Protein kinase C-dependent phosphorylation of transient receptor potential canonical 6 (TRPC6) on serine 448 causes channel inhibition. J Biol Chem 285(52):40534–40543
pubmed: 20961851
pmcid: 3003352
doi: 10.1074/jbc.M110.160051
Gotru SK, Chen W, Kraft P, Becker IC, Wolf K, Stritt S et al (2018) TRPM7 kinase controls calcium responses in arterial thrombosis and stroke in mice. Arterioscler Thromb Vasc Biol 38(2):344–352
pubmed: 29146750
doi: 10.1161/ATVBAHA.117.310391
Mahaut-Smith MP (2013) A role for platelet TRPC channels in the Ca
Ngo ATP, McCarty OJT, Aslan JE (2018) TRPing out platelet calcium: TRPM7 (transient receptor potential melastatin-like 7) modulates calcium mobilization and platelet function via phospholipase C interactions. Arterioscler Thromb Vasc Biol 38(2):285–286
pubmed: 29367228
pmcid: 5788294
doi: 10.1161/ATVBAHA.117.310493
Vemana HP, Karim ZA, Conlon C, Khasawneh FT (2015) A critical role for the transient receptor potential channel type 6 in human platelet activation. PLoS ONE 10(4):e0125764
pubmed: 25928636
pmcid: 4416038
doi: 10.1371/journal.pone.0125764
Chaudhuri P, Rosenbaum MA, Sinharoy P, Damron DS, Birnbaumer L, Graham LM (2016) Membrane translocation of TRPC6 channels and endothelial migration are regulated by calmodulin and PI3 kinase activation. Proc Natl Acad Sci USA 113(8):2110–2115
pubmed: 26858457
pmcid: 4776520
doi: 10.1073/pnas.1600371113
Dionisio N, Albarran L, Berna-Erro A, Hernandez-Cruz JM, Salido GM, Rosado JA (2011) Functional role of the calmodulin- and inositol 1,4,5-trisphosphate receptor-binding (CIRB) site of TRPC6 in human platelet activation. Cell Signal 23(11):1850–1856
Paez Espinosa EV, Murad JP, Ting HJ, Khasawneh FT (2012) Mouse transient receptor potential channel 6: role in hemostasis and thrombogenesis. Biochem Biophys Res Commun 417(2):853–856
Thebault S, Flourakis M, Vanoverberghe K, Vandermoere F, Roudbaraki M, Lehen’kyi V et al (2006) Differential role of transient receptor potential channels in Ca
pubmed: 16489003
doi: 10.1158/0008-5472.CAN-05-0376
Coenen DM, Mastenbroek TG, Cosemans J (2017) Platelet interaction with activated endothelium: mechanistic insights from microfluidics. Blood 130(26):2819–2828
pubmed: 29018081
doi: 10.1182/blood-2017-04-780825
Blasi A, Calvo A, Prado V, Reverter E, Reverter JC, Hernandez-Tejero M et al (2018) Coagulation failure in patients with acute-on-chronic liver failure and decompensated cirrhosis: beyond the international normalized ratio. Hepatology 68(6):2325–2337
Vinayagam S, Sattu K (2020) SARS-CoV-2 and coagulation disorders in different organs. Life Sci 260:118431
pubmed: 32946915
pmcid: 7490584
doi: 10.1016/j.lfs.2020.118431
Kietsiriroje N, Ariens RAS, Ajjan RA (2021) Fibrinolysis in acute and chronic cardiovascular disease. Semin Thromb Hemost 47(5):490–505
pubmed: 33878782
doi: 10.1055/s-0040-1718923
Esmon CT (2005) The interactions between inflammation and coagulation. Br J Haematol 131(4):417–430
pubmed: 16281932
doi: 10.1111/j.1365-2141.2005.05753.x
Ushijima J, Wang L, Ko H, Horiuchi I, Chikazawa K, Sasaki S et al (2018) Rupture of hidden abnormal myometrial vessels during cesarean delivery of a patient with subserosal leiomyoma: a possible pathogenesis of sudden-onset disseminated intravascular coagulation. Clin Case Rep 6(9):1747–1750
pubmed: 30214755
pmcid: 6132163
doi: 10.1002/ccr3.1718
Torngren S, Almgard LE, Blomback M, Norming U, Nyman CR (1990) Blood coagulation alterations after embolic occlusion of the renal circulation. Scand J Urol Nephrol 24(2):141–144
pubmed: 2113313
doi: 10.3109/00365599009180381
van Hinsbergh VW (2002) Coagulation signals for intact blood vessels. Lancet 359(9322):1958–1960
pubmed: 12076547
doi: 10.1016/S0140-6736(02)08846-3
Pranskunas A, Pilvinis V, Dambrauskas Z, Rasimaviciute R, Planciuniene R, Dobozinskas P et al (2012) Early course of microcirculatory perfusion in eye and digestive tract during hypodynamic sepsis. Crit Care 16(3):R83
pubmed: 22587828
pmcid: 3580626
doi: 10.1186/cc11341
Rudd KE, Johnson SC, Agesa KM, Shackelford KA, Tsoi D, Kievlan DR et al (2020) Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study. Lancet 395(10219):200–211
pubmed: 31954465
pmcid: 6970225
doi: 10.1016/S0140-6736(19)32989-7
Mohammad NS, Nazli R, Zafar H, Fatima S (2022) Effects of lipid based Multiple Micronutrients Supplement on the birth outcome of underweight pre-eclamptic women: a randomized clinical trial. Pak J Med Sci 38(1):219–226
pubmed: 35035429
pmcid: 8713215
Joho S, Ushijima R, Nakagaito M, Kinugawa K (2020) Sympathetic overactivation predicts body weight loss in patients with heart failure. Auton Neurosci 223:102625
pubmed: 31896025
doi: 10.1016/j.autneu.2019.102625
Zhang D, Hu W, Tu H, Hackfort BT, Duan B, Xiong W et al (2021) Macrophage depletion in stellate ganglia alleviates cardiac sympathetic overactivation and ventricular arrhythmogenesis by attenuating neuroinflammation in heart failure. Basic Res Cardiol 116(1):28
pubmed: 33884509
pmcid: 8060235
doi: 10.1007/s00395-021-00871-x
Gubbi S, Nazari MA, Taieb D, Klubo-Gwiezdzinska J, Pacak K (2020) Catecholamine physiology and its implications in patients with COVID-19. Lancet Diabetes Endocrinol 8(12):978–986
pubmed: 33128872
pmcid: 7598304
doi: 10.1016/S2213-8587(20)30342-9
Sacha GL, Lam SW, Wang L, Duggal A, Reddy AJ, Bauer SR (2022) Association of catecholamine dose, lactate, and shock duration at vasopressin initiation with mortality in patients with septic shock. Crit Care Med 50(4):614–623
pubmed: 34582425
doi: 10.1097/CCM.0000000000005317
Zaldivia MT, Rivera J, Hering D, Marusic P, Sata Y, Lim B et al (2017) Renal denervation reduces monocyte activation and monocyte-platelet aggregate formation: an anti-inflammatory effect relevant for cardiovascular risk. Hypertension 69(2):323–331
pubmed: 27956575
doi: 10.1161/HYPERTENSIONAHA.116.08373
Patel P, Walborn A, Rondina M, Fareed J, Hoppensteadt D (2019) Markers of inflammation and infection in sepsis and disseminated intravascular coagulation. Clin Appl Thromb Hemost 25:1076029619843338
pubmed: 30991817
pmcid: 6714897
doi: 10.1177/1076029619843338
Stief TW, Ijagha O, Weiste B, Herzum I, Renz H, Max M (2007) Analysis of hemostasis alterations in sepsis. Blood Coagul Fibrinolysis 18(2):179–186
pubmed: 17287636
doi: 10.1097/MBC.0b013e328040bf9a
Al-Yahya AM, Al-Masri AA, El Eter EA, Hersi A, Lateef R, Mawlana O (2018) Progranulin inhibits platelet aggregation and prolongs bleeding time in rats. Eur Rev Med Pharmacol Sci 22(10):3240–3248
Deschmann E, Saxonhouse MA, Feldman HA, Norman M, Barbian M, Sola-Visner M (2019) Association between in vitro bleeding time and bleeding in preterm infants with thrombocytopenia. JAMA Pediatr 173(4):393–394
Karabacak M, Dogan A, Aksoy F, Ozaydin M, Erdogan D, Karabacak P (2014) Both carvedilol and nebivolol may improve platelet function and prothrombotic state in patients with nonischemic heart failure. Angiology 65(6):533–537
pubmed: 23671213
doi: 10.1177/0003319713489340
Verhamme P, Hoylaerts MF (2006) The pivotal role of the endothelium in haemostasis and thrombosis. Acta Clin Belg 61(5):213–219
pubmed: 17240734
doi: 10.1179/acb.2006.036
Dunser MW, Hasibeder WR (2009) Sympathetic overstimulation during critical illness: adverse effects of adrenergic stress. J Intensive Care Med 24(5):293–316
pubmed: 19703817
doi: 10.1177/0885066609340519
Ittner C, Burek M, Stork S, Nagai M, Forster CY (2020) Increased catecholamine levels and inflammatory mediators alter barrier properties of brain microvascular endothelial cells in vitro. Front Cardiovasc Med 7:73
pubmed: 32432126
pmcid: 7214675
doi: 10.3389/fcvm.2020.00073
Kjeldsen SE, Weder AB, Egan B, Neubig R, Zweifler AJ, Julius S (1995) Effect of circulating epinephrine on platelet function and hematocrit. Hypertension 25(5):1096–1105
pubmed: 7737722
doi: 10.1161/01.HYP.25.5.1096
Mendez E, Calzada C, Ocharan E, Sierra A, Castillo C, Ramirez I et al (2006) Differential expression of alpha1-adrenergic receptor subtypes in coronary microvascular endothelial cells in culture. Eur J Pharmacol 546(1–3):127–133
pubmed: 16904663
doi: 10.1016/j.ejphar.2006.06.070
Heijnen CJ, Rouppe van der Voort C, van de Pol M, Kavelaars A (2002) Cytokines regulate alpha(1)-adrenergic receptor mRNA expression in human monocytic cells and endothelial cells. J Neuroimmunol 125(1–2):66–72
Akinaga J, Lima V, Kiguti LR, Hebeler-Barbosa F, Alcantara-Hernandez R, Garcia-Sainz JA et al (2013) Differential phosphorylation, desensitization, and internalization of alpha1A-adrenoceptors activated by norepinephrine and oxymetazoline. Mol Pharmacol 83(4):870–881
Perez-Aso M, Segura V, Monto F, Barettino D, Noguera MA, Milligan G et al (2013) The three alpha1-adrenoceptor subtypes show different spatio-temporal mechanisms of internalization and ERK1/2 phosphorylation. Biochim Biophys Acta 1833(10):2322–2333
January B, Seibold A, Whaley B, Hipkin RW, Lin D, Schonbrunn A et al (1997) beta2-adrenergic receptor desensitization, internalization, and phosphorylation in response to full and partial agonists. J Biol Chem 272(38):23871–23879
pubmed: 9295336
doi: 10.1074/jbc.272.38.23871
Mangmool S, Haga T, Kobayashi H, Kim KM, Nakata H, Nishida M et al (2006) Clathrin required for phosphorylation and internalization of beta2-adrenergic receptor by G protein-coupled receptor kinase 2 (GRK2). J Biol Chem 281(42):31940–31949
pubmed: 16920721
doi: 10.1016/S0021-9258(19)84108-X
Fan X, Gu X, Zhao R, Zheng Q, Li L, Yang W et al (2016) Cardiac beta2-adrenergic receptor phosphorylation at Ser355/356 regulates receptor internalization and functional resensitization. PLoS ONE 11(8):e0161373
pubmed: 27541735
pmcid: 4991819
doi: 10.1371/journal.pone.0161373
Albarran L, Berna-Erro A, Dionisio N, Redondo PC, Lopez E, Lopez JJ et al (2014) TRPC6 participates in the regulation of cytosolic basal calcium concentration in murine resting platelets. Biochim Biophys Acta 1843(4):789–796
Singh I, Knezevic N, Ahmmed GU, Kini V, Malik AB, Mehta D (2007) Galphaq-TRPC6-mediated Ca
pubmed: 17197445
doi: 10.1074/jbc.M608288200
Weber EW, Han F, Tauseef M, Birnbaumer L, Mehta D, Muller WA (2015) TRPC6 is the endothelial calcium channel that regulates leukocyte transendothelial migration during the inflammatory response. J Exp Med 212(11):1883–1899
pubmed: 26392222
pmcid: 4612081
doi: 10.1084/jem.20150353
Wang D, Wang Q, Ji T, Yang H, Kong F, Jiao J (2020) The role of TRPC6 in alpha1-AR activation-induced calcium signal changes in human podocytes. Ann Palliat Med 9(4):1596–1605
pubmed: 32692192
doi: 10.21037/apm-19-602
Aires V, Hichami A, Boulay G, Khan NA (2007) Activation of TRPC6 calcium channels by diacylglycerol (DAG)-containing arachidonic acid: a comparative study with DAG-containing docosahexaenoic acid. Biochimie 89(8):926–937
pubmed: 17532549
doi: 10.1016/j.biochi.2006.10.016
Abdinghoff J, Servello D, Jacobs T, Beckmann A, Tschernig T (2022) Evaluation of the presence of TRPC6 channels in human vessels: a pilot study using immunohistochemistry. Biomed Rep 16(5):42
pubmed: 35371476
pmcid: 8972230
doi: 10.3892/br.2022.1525
Levi M, Ten Cate H (1999) Disseminated intravascular coagulation. N Engl J Med 341(8):586–592
pubmed: 10451465
doi: 10.1056/NEJM199908193410807
Yau JW, Teoh H, Verma S (2015) Endothelial cell control of thrombosis. BMC Cardiovasc Disord 15:130
pubmed: 26481314
pmcid: 4617895
doi: 10.1186/s12872-015-0124-z
Arellano-Rodrigo E, Alvarez-Larran A, Reverter JC, Colomer D, Villamor N, Bellosillo B et al (2009) Platelet turnover, coagulation factors, and soluble markers of platelet and endothelial activation in essential thrombocythemia: relationship with thrombosis occurrence and JAK2 V617F allele burden. Am J Hematol 84(2):102–108
Nhek S, Clancy R, Lee KA, Allen NM, Barrett TJ, Marcantoni E et al (2017) Activated platelets induce endothelial cell activation via an interleukin-1beta pathway in systemic lupus erythematosus. Arterioscler Thromb Vasc Biol 37(4):707–716
pubmed: 28153882
pmcid: 5597960
doi: 10.1161/ATVBAHA.116.308126
Vischer UM (2006) von Willebrand factor, endothelial dysfunction, and cardiovascular disease. J Thromb Haemost 4(6):1186–1193
pubmed: 16706957
doi: 10.1111/j.1538-7836.2006.01949.x
Vischer UM, de Moerloose P (1999) von Willebrand factor: from cell biology to the clinical management of von Willebrand’s disease. Crit Rev Oncol Hematol 30(2):93–109
pubmed: 10439057
doi: 10.1016/S1040-8428(98)00045-6
Terraube V, O’Donnell JS, Jenkins PV (2010) Factor VIII and von Willebrand factor interaction: biological, clinical and therapeutic importance. Haemophilia 16(1):3–13
pubmed: 19473409
doi: 10.1111/j.1365-2516.2009.02005.x
O’Sullivan JM, Ward S, Lavin M, O’Donnell JS (2018) von Willebrand factor clearance—biological mechanisms and clinical significance. Br J Haematol 183(2):185–195
pubmed: 30378120
doi: 10.1111/bjh.15565
Bonfanti R, Furie BC, Furie B, Wagner DD (1989) PADGEM (GMP140) is a component of Weibel–Palade bodies of human endothelial cells. Blood 73(5):1109–1112
pubmed: 2467701
doi: 10.1182/blood.V73.5.1109.1109
Stenberg PE, McEver RP, Shuman MA, Jacques YV, Bainton DF (1985) A platelet alpha-granule membrane protein (GMP-140) is expressed on the plasma membrane after activation. J Cell Biol 101(3):880–886
pubmed: 2411738
doi: 10.1083/jcb.101.3.880
Dunlop LC, Skinner MP, Bendall LJ, Favaloro EJ, Castaldi PA, Gorman JJ et al (1992) Characterization of GMP-140 (P-selectin) as a circulating plasma protein. J Exp Med 175(4):1147–1150
pubmed: 1372646
doi: 10.1084/jem.175.4.1147
Hartwell DW, Mayadas TN, Berger G, Frenette PS, Rayburn H, Hynes RO et al (1998) Role of P-selectin cytoplasmic domain in granular targeting in vivo and in early inflammatory responses. J Cell Biol 143(4):1129–1141
pubmed: 9817767
pmcid: 2132959
doi: 10.1083/jcb.143.4.1129
Burger PC, Wagner DD (2003) Platelet P-selectin facilitates atherosclerotic lesion development. Blood 101(7):2661–2666
pubmed: 12480714
doi: 10.1182/blood-2002-07-2209
Andre P (2004) P-selectin in haemostasis. Br J Haematol 126(3):298–306
pubmed: 15257701
doi: 10.1111/j.1365-2141.2004.05032.x
Cheresh DA (1993) Integrins: structure, function, and biological properties. Adv Mol Cell Biol 6:225–252
Abumiya T, Lucero J, Heo JH, Tagaya M, Koziol JA, Copeland BR et al (1999) Activated microvessels express vascular endothelial growth factor and integrin alpha(v)beta3 during focal cerebral ischemia. J Cereb Blood Flow Metab 19(9):1038–1050
pubmed: 10478656
doi: 10.1097/00004647-199909000-00012
Schwartz ML, Pizzo SV, Hill RL, McKee PA (1973) Human factor XIII from plasma and platelets. Molecular weights, subunit structures, proteolytic activation, and cross-linking of fibrinogen and fibrin. J Biol Chem 248(4):1395–1407
Dardik R, Shenkman B, Tamarin I, Eskaraev R, Harsfalvi J, Varon D et al (2002) Factor XIII mediates adhesion of platelets to endothelial cells through alpha(v)beta(3) and glycoprotein IIb/IIIa integrins. Thromb Res 105(4):317–323
pubmed: 12031826
doi: 10.1016/S0049-3848(02)00014-2