Seroprevalence of high incidence congenital infections among pregnant women in Coatepeque, Guatemala and surrounding areas, 2017-2018.
Infant, Newborn
Pregnancy
Female
Humans
Young Adult
Adult
Pregnancy Complications, Infectious
/ diagnosis
Pregnant Women
Syphilis
/ epidemiology
Seroepidemiologic Studies
Cohort Studies
Incidence
Guatemala
/ epidemiology
Immunoglobulin G
Rubella
/ epidemiology
Toxoplasma
Cytomegalovirus Infections
/ epidemiology
Immunoglobulin M
Antibodies, Viral
Infant, Newborn, Diseases
Antibodies, Protozoan
HIV Infections
Journal
PLoS neglected tropical diseases
ISSN: 1935-2735
Titre abrégé: PLoS Negl Trop Dis
Pays: United States
ID NLM: 101291488
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
received:
05
12
2022
accepted:
15
03
2023
revised:
04
05
2023
medline:
8
5
2023
pubmed:
24
4
2023
entrez:
24
04
2023
Statut:
epublish
Résumé
Maternal infections during pregnancy can potentially cause birth defects and severe adverse effects in infants. From 2017 to 2018, we investigated the seroprevalence of five antibodies among 436 mother-infant pairs enrolled in a pregnancy cohort study in Coatepeque, Guatemala. Upon enrollment (< 20 weeks gestational age) and shortly after delivery, we measured the prevalence of IgG and IgM antibodies against Toxoplasma gondii (T. gondii), rubella, and cytomegalovirus (CMV) in mothers and newborns and used rapid tests to detect HIV and syphilis (Treponema pallidum) in mothers. The mean cohort age was 24.5 years. Maternal T. gondii IgM and IgG seropositivity was 1.9% and 69.7%, respectively. No women were positive for HIV, syphilis, or rubella IgM. Maternal rubella IgG seropositivity was 80.8% and significantly increased with age. Maternal CMV IgM and IgG seropositivity were 2.3% and 99.5%, respectively. Of the 323 women tested at both timepoints, IgM reactivation occurred in one woman for T. gondii infection and in eight for CMV. No newborn was seropositive for CMV IgM or rubella IgM. One newborn was seropositive for T. gondii IgM. Congenital T. gondii and CMV infections are important public health issues for pregnant women, newborns, and healthcare providers in Coatepeque and Guatemala.
Identifiants
pubmed: 37093863
doi: 10.1371/journal.pntd.0011248
pii: PNTD-D-22-01517
pmc: PMC10159341
doi:
Substances chimiques
Immunoglobulin G
0
Immunoglobulin M
0
Antibodies, Viral
0
Antibodies, Protozoan
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0011248Informations de copyright
Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
Déclaration de conflit d'intérêts
The authors have no competing interests.
Références
J Biomed Inform. 2009 Apr;42(2):377-81
pubmed: 18929686
Radiology. 2017 Dec;285(3):744-761
pubmed: 29155634
Bol Oficina Sanit Panam. 1977 Sep;83(3):218-22
pubmed: 200251
J Immunol Methods. 2017 Dec;451:61-70
pubmed: 28882612
Arch Pediatr. 2017 Oct;24(10):911-913
pubmed: 28870816
Lancet. 2016 Feb 20;387(10020):719-21
pubmed: 26876373
J Int Assoc Physicians AIDS Care (Chic). 2010 Sep-Oct;9(5):313-7
pubmed: 20841440
J Infect Dis. 2011 Sep 1;204 Suppl 2:S598-602
pubmed: 21954253
N Engl J Med. 2018 Mar 15;378(11):1055-1056
pubmed: 29539290
Enferm Infecc Microbiol Clin. 2011 Dec;29 Suppl 5:15-20
pubmed: 22305665
Clin Microbiol Infect. 2006 Jun;12(6):504-12
pubmed: 16700697
Trends Parasitol. 2016 Jun;32(6):492-506
pubmed: 27167666
Ciba Found Symp. 1979;(77):171-86
pubmed: 261759
Bull World Health Organ. 2019 Aug 01;97(8):548-562P
pubmed: 31384073
Curr Womens Health Rep. 2002 Aug;2(4):253-8
pubmed: 12150751
Expert Rev Anti Infect Ther. 2016 Sep;14(9):845-61
pubmed: 27442227
Front Cell Infect Microbiol. 2017 Dec 08;7:486
pubmed: 29276699
Curr Opin Pediatr. 2017 Feb;29(1):94-96
pubmed: 28027061
Clin Microbiol Rev. 2019 Dec 11;33(1):
pubmed: 31826871
Int J Infect Dis. 2014 May;22:44-8
pubmed: 24631522
JAMA Netw Open. 2021 Aug 2;4(8):e2120736
pubmed: 34424308
Am J Reprod Immunol. 2010 Jun;63(6):425-33
pubmed: 20367629
Congenit Anom (Kyoto). 2016 Mar;56(2):73-8
pubmed: 26499091
Arch Pathol Lab Med. 2017 Jan;141(1):18-25
pubmed: 27763793
Clin Perinatol. 2015 Mar;42(1):77-103, viii
pubmed: 25677998
Travel Med Infect Dis. 2018 May - Jun;23:14-20
pubmed: 29471046
Virology (Auckl). 2017 May 18;8:1178122X17708993
pubmed: 28579764
Rev Med Virol. 2010 Jul;20(4):202-13
pubmed: 20564615
Eur J Epidemiol. 1992 Jul;8(4):516-20
pubmed: 1397218
mSphere. 2018 Aug 8;3(4):
pubmed: 30089647
J Zoo Wildl Med. 2005 Mar;36(1):121-3
pubmed: 17315469
PLoS Negl Trop Dis. 2019 Oct 14;13(10):e0007807
pubmed: 31609966
Rev Med Virol. 2019 May;29(3):e2034
pubmed: 30706584
Lancet Infect Dis. 2018 Jan;18(1):15-16
pubmed: 29303729
Sex Transm Infect. 2011 Mar;87(2):136-40
pubmed: 21071565
Nat Rev Microbiol. 2016 Nov;14(11):707-715
pubmed: 27573577
Clin Microbiol Rev. 2013 Jan;26(1):86-102
pubmed: 23297260
Am J Trop Med Hyg. 2005 Mar;72(3):295-300
pubmed: 15772325
Enferm Infecc Microbiol Clin. 2015 Jul;33 Suppl 2:20-6
pubmed: 26320992
J Infect Dis. 2011 Sep 1;204 Suppl 2:S571-8
pubmed: 21954249
Sci Rep. 2020 Jul 21;10(1):12102
pubmed: 32694844
Int J Med Microbiol. 2014 Oct;304(7):917-29
pubmed: 25240467
Emerg Infect Dis. 2019 Apr;25(4):625-632
pubmed: 30698523