Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2.


Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
24 04 2023
Historique:
received: 15 09 2021
accepted: 03 04 2023
medline: 26 4 2023
pubmed: 25 4 2023
entrez: 24 04 2023
Statut: epublish

Résumé

Botulinum neurotoxin E (BoNT/E) is one of the major causes of human botulism and paradoxically also a promising therapeutic agent. Here we determined the co-crystal structures of the receptor-binding domain of BoNT/E (H

Identifiants

pubmed: 37095076
doi: 10.1038/s41467-023-37860-8
pii: 10.1038/s41467-023-37860-8
pmc: PMC10125960
doi:

Substances chimiques

botulinum toxin type E T579M564JY
Botulinum Toxins, Type A EC 3.4.24.69
Membrane Glycoproteins 0
Nerve Tissue Proteins 0

Types de publication

Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

2338

Subventions

Organisme : NIH HHS
ID : S10 OD021527
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS080833
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI156092
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI158503
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI139087
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI123920
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30 GM124165
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI125704
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI132387
Pays : United States

Informations de copyright

© 2023. The Author(s).

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Auteurs

Zheng Liu (Z)

Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, 92697, USA.

Pyung-Gang Lee (PG)

Department of Urology, Boston Children's Hospital, Boston, MA, 02115, USA.
Department of Microbiology and Department of Surgery, Harvard Medical School, Boston, MA, 02115, USA.

Nadja Krez (N)

Institute of Toxicology, Hannover Medical School, Hannover, 30623, Germany.

Kwok-Ho Lam (KH)

Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, 92697, USA.

Hao Liu (H)

Department of Urology, Boston Children's Hospital, Boston, MA, 02115, USA.
Department of Microbiology and Department of Surgery, Harvard Medical School, Boston, MA, 02115, USA.

Adina Przykopanski (A)

Institute of Toxicology, Hannover Medical School, Hannover, 30623, Germany.

Peng Chen (P)

Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, 92697, USA.

Guorui Yao (G)

Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, 92697, USA.

Sicai Zhang (S)

Department of Urology, Boston Children's Hospital, Boston, MA, 02115, USA.
Department of Microbiology and Department of Surgery, Harvard Medical School, Boston, MA, 02115, USA.

Jacqueline M Tremblay (JM)

Tufts Cummings School of Veterinary Medicine, North Grafton, MA, 01536, USA.

Kay Perry (K)

NE-CAT and Department of Chemistry and Chemical Biology, Cornell University, Argonne National Laboratory, Argonne, IL, 60439, USA.

Charles B Shoemaker (CB)

Tufts Cummings School of Veterinary Medicine, North Grafton, MA, 01536, USA.

Andreas Rummel (A)

Institute of Toxicology, Hannover Medical School, Hannover, 30623, Germany.

Min Dong (M)

Department of Urology, Boston Children's Hospital, Boston, MA, 02115, USA. Min.Dong@childrens.harvard.edu.
Department of Microbiology and Department of Surgery, Harvard Medical School, Boston, MA, 02115, USA. Min.Dong@childrens.harvard.edu.

Rongsheng Jin (R)

Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, 92697, USA. r.jin@uci.edu.

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Classifications MeSH