Central role for neurally dysregulated IL-17A in dynamic networks of systemic and local inflammation in combat casualties.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
24 04 2023
24 04 2023
Historique:
received:
06
09
2022
accepted:
15
04
2023
medline:
26
4
2023
pubmed:
25
4
2023
entrez:
24
04
2023
Statut:
epublish
Résumé
Dynamic Network Analysis (DyNA) and Dynamic Hypergraphs (DyHyp) were used to define protein-level inflammatory networks at the local (wound effluent) and systemic circulation (serum) levels from 140 active-duty, injured service members (59 with TBI and 81 non-TBI). Interleukin (IL)-17A was the only biomarker elevated significantly in both serum and effluent in TBI vs. non-TBI casualties, and the mediator with the most DyNA connections in TBI wounds. DyNA combining serum and effluent data to define cross-compartment correlations suggested that IL-17A bridges local and systemic circulation at late time points. DyHyp suggested that systemic IL-17A upregulation in TBI patients was associated with tumor necrosis factor-α, while IL-17A downregulation in non-TBI patients was associated with interferon-γ. Correlation analysis suggested differential upregulation of pathogenic Th17 cells, non-pathogenic Th17 cells, and memory/effector T cells. This was associated with reduced procalcitonin in both effluent and serum of TBI patients, in support of an antibacterial effect of Th17 cells in TBI patients. Dysregulation of Th17 responses following TBI may drive cross-compartment inflammation following combat injury, counteracting wound infection at the cost of elevated systemic inflammation.
Identifiants
pubmed: 37095162
doi: 10.1038/s41598-023-33623-z
pii: 10.1038/s41598-023-33623-z
pmc: PMC10126120
doi:
Substances chimiques
Interleukin-17
0
Tumor Necrosis Factor-alpha
0
Interferon-gamma
82115-62-6
Biomarkers
0
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
6618Informations de copyright
© 2023. The Author(s).
Références
Int J Mol Med. 2021 Jul;48(1):
pubmed: 34036377
Front Immunol. 2022 Feb 09;13:753570
pubmed: 35222368
Clin Immunol. 2013 Feb;146(2):140-52
pubmed: 23333555
IEEE Trans Pattern Anal Mach Intell. 2022 May;44(5):2548-2566
pubmed: 33211654
Front Immunol. 2021 Jan 18;11:589304
pubmed: 33537029
Ann Surg. 2019 Sep;270(3):535-543
pubmed: 31348045
Antioxid Redox Signal. 2021 Dec;35(16):1393-1406
pubmed: 33860683
PLoS One. 2013 Nov 11;8(11):e78202
pubmed: 24244295
Surg Infect (Larchmt). 2011 Oct;12(5):351-7
pubmed: 21936666
Antioxid Redox Signal. 2015 Dec 10;23(17):1370-87
pubmed: 26560096
Nat Immunol. 2012 Oct;13(10):991-9
pubmed: 22961052
Int J Mol Sci. 2017 May 11;18(5):
pubmed: 28492497
Front Pharmacol. 2016 Nov 01;7:383
pubmed: 27847476
Nat Rev Immunol. 2006 Apr;6(4):318-28
pubmed: 16557263
Ann Surg. 2009 Dec;250(6):1002-7
pubmed: 19953718
Front Pharmacol. 2016 Sep 27;7:342
pubmed: 27729864
Sci Transl Med. 2015 Apr 29;7(285):285ra61
pubmed: 25925680
Cell Rep Med. 2021 Dec 21;2(12):100478
pubmed: 35028617
Mol Med. 2017 Jan;22:821-829
pubmed: 27900388
Crit Care Med. 2016 Nov;44(11):e1074-e1081
pubmed: 27513538
Shock. 2018 Mar;49(3):259-268
pubmed: 28930911
Neuroscience. 2014 Apr 25;266:56-65
pubmed: 24530657
J Exp Med. 2005 Jan 17;201(2):233-40
pubmed: 15657292
Front Psychol. 2013 Jan 10;3:606
pubmed: 23335907
Bioinformatics. 2009 Nov 1;25(21):2831-8
pubmed: 19648139
Lancet Infect Dis. 2013 May;13(5):426-35
pubmed: 23375419
Nat Rev Immunol. 2010 Jul;10(7):479-89
pubmed: 20559326
Neuromolecular Med. 2017 Dec;19(4):541-554
pubmed: 28916896
World J Emerg Surg. 2019 Nov 29;14:53
pubmed: 31798673
Ann Surg. 2016 Jan;263(1):191-8
pubmed: 25371118
Nat Immunol. 2007 Dec;8(12):1390-7
pubmed: 17994024
Annu Rev Immunol. 2007;25:821-52
pubmed: 17201677
Plast Reconstr Surg. 2011 Jan;127 Suppl 1:21S-26S
pubmed: 21200268
Mol Med. 2021 Jun 24;27(1):65
pubmed: 34167455
J Neuroimmunol. 2007 Feb;183(1-2):1-6
pubmed: 17188367
Front Neurol. 2013 Mar 04;4:18
pubmed: 23459929
J Neurotrauma. 2016 Aug 15;33(16):1492-500
pubmed: 26542887
JCI Insight. 2021 Jan 25;6(2):
pubmed: 33320841
Bioinformatics. 2021 May 17;37(7):1000-1007
pubmed: 32886115
Neurocrit Care. 2021 Oct;35(2):559-572
pubmed: 33403583
Nature. 2002 Dec 19-26;420(6917):853-9
pubmed: 12490958
Front Immunol. 2022 May 19;13:908618
pubmed: 35663944
Mil Med. 2014 Aug;179(8):827-38
pubmed: 25102525
Front Aging Neurosci. 2020 Sep 29;12:566922
pubmed: 33132897
PLoS One. 2013 Dec 03;8(12):e79804
pubmed: 24312451
Nucleic Acids Res. 2018 Jul 2;46(W1):W486-W494
pubmed: 29762782
NeuroRehabilitation. 2016 Jun 30;39(3):351-61
pubmed: 27497468
Annu Rev Immunol. 2009;27:485-517
pubmed: 19132915
Curr Comput Aided Drug Des. 2011 Jun;7(2):122-32
pubmed: 21539508
Crit Care Med. 2017 Sep;45(9):1523-1530
pubmed: 28671900
Biomark Med. 2010 Jun;4(3):465-73
pubmed: 20550480
PLoS One. 2011 May 10;6(5):e19424
pubmed: 21573002
Clin Infect Dis. 2004 Jul 15;39(2):206-17
pubmed: 15307030
Crit Care Med. 2014 Jun;42(6):1487-97
pubmed: 24584064
J Immunol. 1990 Apr 15;144(8):2999-3007
pubmed: 2109008
Cytokine. 2015 Jul;74(1):18-26
pubmed: 25464925
World Neurosurg. 2021 Nov;155:e418-e438
pubmed: 34438102
EBioMedicine. 2022 Feb;76:103860
pubmed: 35124428
Sci Rep. 2021 May 6;11(1):9703
pubmed: 33958628
Curr Opin Immunol. 2011 Dec;23(6):702-6
pubmed: 21899997
Libyan J Med. 2009 Sep 01;4(3):97-103
pubmed: 21483522
Curr Protoc Bioinformatics. 2019 Dec;68(1):e86
pubmed: 31756036