Diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a refined classification from the European society for blood and marrow transplantation (EBMT).

Humans Adult Hepatic Veno-Occlusive Disease / diagnosis Bone Marrow Vascular Diseases Syndrome Hematopoietic Stem Cell Transplantation / adverse effects

Journal

Bone marrow transplantation

ISSN: 1476-5365

Titre abrégé: Bone Marrow Transplant

Pays: England

ID NLM: 8702459

Informations de publication

Date de publication:
07 2023

Historique:

received: 07 04 2023

accepted: 18 04 2023

revised: 16 04 2023

medline: 10 7 2023

pubmed: 25 4 2023

entrez: 24 04 2023

Statut: ppublish

Résumé

Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life-threatening complication that can develop after hematopoietic cell transplantation (HCT). A new definition for diagnosis, and a severity grading system for SOS/VOD in adult patients, was reported a few years ago on behalf of the European Society for Blood and Marrow Transplantation (EBMT). The aim of this work is to update knowledge regarding diagnosis and severity assessment of SOS/VOD in adult patients, and also its pathophysiology and treatment. In particular, we now propose to refine the previous classification and distinguish probable, clinical and proven SOS/VOD at diagnosis. We also provide an accurate definition of multiorgan dysfunction (MOD) for SOS/VOD severity grading based on Sequential Organ Failure Assessment (SOFA) score.

Identifiants

DOI: 10.1038/s41409-023-01992-8 PMID: 37095231

pubmed: 37095231

doi: 10.1038/s41409-023-01992-8

pii: 10.1038/s41409-023-01992-8

doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

Pagination

749-754

Informations de copyright

Références

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