Protective Effect of Modified Hemoglobin on Rabbits and Goats in High-Altitude Sickness.
high attitudes
modified hemoglobin
oxygen-carrying ability
oxygen-releasing ability
vital organ function
Journal
Advanced biology
ISSN: 2701-0198
Titre abrégé: Adv Biol (Weinh)
Pays: Germany
ID NLM: 101775319
Informations de publication
Date de publication:
08 2023
08 2023
Historique:
revised:
06
02
2023
received:
15
11
2022
medline:
23
8
2023
pubmed:
25
4
2023
entrez:
25
4
2023
Statut:
ppublish
Résumé
The prevalence and severity of high-altitude sickness increases with increasing altitude. Prevention of hypoxia caused by high-altitude sickness is an urgent problem. As a novel oxygen-carrying fluid, modified hemoglobin can carry oxygen in a full oxygen partial pressure environment and release oxygen in a low oxygen partial pressure environment. It is unclear whether modified hemoglobin can improve hypoxic injury on a plateau. Using hypobaric chamber rabbit (5000 m) and plateau goat (3600 m) models, general behavioral scores and vital signs, hemodynamic, vital organ functions, and blood gas are measured. The results show that the general behavioral scores and vital signs decrease significantly in the hypobaric chamber or plateau, and the modified hemoglobin can effectively improve the general behavioral scores and vital signs in rabbits and goats, and reduce the degree of damage to vital organs. Further studies reveal that arterial partial pressure of oxygen (PaO
Identifiants
pubmed: 37097708
doi: 10.1002/adbi.202200307
doi:
Substances chimiques
Oxygen
S88TT14065
Hemoglobins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2200307Informations de copyright
© 2023 The Authors. Advanced Biology published by Wiley-VCH GmbH.
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