Senescent T cells: Beneficial and detrimental roles.
T cell
TEMRA
aging
senescence
terminally differentiated cell
Journal
Immunological reviews
ISSN: 1600-065X
Titre abrégé: Immunol Rev
Pays: England
ID NLM: 7702118
Informations de publication
Date de publication:
07 2023
07 2023
Historique:
revised:
20
03
2023
received:
02
02
2023
accepted:
01
04
2023
medline:
21
7
2023
pubmed:
25
4
2023
entrez:
25
4
2023
Statut:
ppublish
Résumé
As the thymus involutes during aging, the T-cell pool has to be maintained by the periodic expansion of preexisting T cells during adulthood. A conundrum is that repeated episodes of activation and proliferation drive the differentiation of T cells toward replicative senescence, due to telomere erosion. This review discusses mechanisms that regulate the end-stage differentiation (senescence) of T cells. Although these cells, within both CD4 and CD8 compartments, lose proliferative activity after antigen-specific challenge, they acquire innate-like immune function. While this may confer broad immune protection during aging, these senescent T cells may also cause immunopathology, especially in the context of excessive inflammation in tissue microenvironments.
Substances chimiques
Antigens
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
160-175Subventions
Organisme : Medical Research Council
ID : MR/P00184X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/T015853/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/T030534/1
Pays : United Kingdom
Informations de copyright
© 2023 The Authors. Immunological Reviews published by John Wiley & Sons Ltd.
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