Bioinspired, ingestible electroceutical capsules for hunger-regulating hormone modulation.

Animals Swine Hunger Robotics Hormones

Journal

Science robotics
ISSN: 2470-9476
Titre abrégé: Sci Robot
Pays: United States
ID NLM: 101733136

Informations de publication

Date de publication:
26 04 2023
Historique:
medline: 28 4 2023
pubmed: 26 4 2023
entrez: 26 4 2023
Statut: ppublish

Résumé

The gut-brain axis, which is mediated via enteric and central neurohormonal signaling, is known to regulate a broad set of physiological functions from feeding to emotional behavior. Various pharmaceuticals and surgical interventions, such as motility agents and bariatric surgery, are used to modulate this axis. Such approaches, however, are associated with off-target effects or post-procedure recovery time and expose patients to substantial risks. Electrical stimulation has also been used to attempt to modulate the gut-brain axis with greater spatial and temporal resolution. Electrical stimulation of the gastrointestinal (GI) tract, however, has generally required invasive intervention for electrode placement on serosal tissue. Stimulating mucosal tissue remains challenging because of the presence of gastric and intestinal fluid, which can influence the effectiveness of local luminal stimulation. Here, we report the development of a bioinspired ingestible fluid-wicking capsule for active stimulation and hormone modulation (FLASH) capable of rapidly wicking fluid and locally stimulating mucosal tissue, resulting in systemic modulation of an orexigenic GI hormone. Drawing inspiration from

Identifiants

DOI: 10.1126/scirobotics.ade9676 PMID: 37099636 PMC: PMC10508349
pubmed: 37099636
doi: 10.1126/scirobotics.ade9676
pmc: PMC10508349
mid: NIHMS1914954
doi:

Substances chimiques

Hormones 0

Types de publication

Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

eade9676

Subventions

Organisme : NIDDK NIH HHS
ID : F32 DK122762
Pays : United States

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Auteurs

Khalil B Ramadi (KB)

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Division of Engineering, New York University Abu Dhabi, Abu Dhabi, UAE.
Tandon School of Engineering, New York University, New York, NY 11201, USA.
ORCID: 0000-0002-5864-2386

James C McRae (JC)

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

George Selsing (G)

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
ORCID: 0000-0003-0223-4006

Arnold Su (A)

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Rafael Fernandes (R)

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
ORCID: 0009-0008-6886-9403

Maela Hickling (M)

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
ORCID: 0009-0005-8392-9353

Brandon Rios (B)

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
ORCID: 0000-0002-8716-6817

Sahab Babaee (S)

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
ORCID: 0000-0003-4771-7853

Seokkee Min (S)

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
ORCID: 0000-0002-7308-6840

Declan Gwynne (D)

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Neil Zixun Jia (NZ)

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Aleyah Aragon (A)

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
ORCID: 0009-0005-4415-7063

Keiko Ishida (K)

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
ORCID: 0000-0003-0894-296X

Johannes Kuosmanen (J)

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Josh Jenkins (J)

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
ORCID: 0000-0001-7698-9888

Alison Hayward (A)

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
ORCID: 0000-0002-9581-8563

Ken Kamrin (K)

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
ORCID: 0000-0002-5154-9787

Giovanni Traverso (G)

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
ORCID: 0000-0001-7851-4077

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Classifications MeSH

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