Click chemistry: a transformative technology in nuclear medicine.
Journal
Nature protocols
ISSN: 1750-2799
Titre abrégé: Nat Protoc
Pays: England
ID NLM: 101284307
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
received:
29
11
2022
accepted:
10
03
2023
medline:
12
6
2023
pubmed:
27
4
2023
entrez:
26
4
2023
Statut:
ppublish
Résumé
The 2022 Nobel Prize in Chemistry was awarded to Professors K. Barry Sharpless, Morten Meldal and Carolyn Bertozzi for their pioneering roles in the advent of click chemistry. Sharpless and Meldal worked to develop the canonical click reaction-the copper-catalyzed azide-alkyne cycloaddition-while Bertozzi opened new frontiers with the creation of the bioorthogonal strain-promoted azide-alkyne cycloaddition. These two reactions have revolutionized chemical and biological science by facilitating selective, high yielding, rapid and clean ligations and by providing unprecedented ways to manipulate living systems. Click chemistry has affected every aspect of chemistry and chemical biology, but few disciplines have been impacted as much as radiopharmaceutical chemistry. The importance of speed and selectivity in radiochemistry make it an almost tailor-made application of click chemistry. In this Perspective, we discuss the ways in which the copper-catalyzed azide-alkyne cycloaddition, the strain-promoted azide-alkyne cycloaddition and a handful of 'next-generation' click reactions have transformed radiopharmaceutical chemistry, both as tools for more efficient radiosyntheses and as linchpins of technologies that have the potential to improve nuclear medicine.
Identifiants
pubmed: 37100960
doi: 10.1038/s41596-023-00825-8
pii: 10.1038/s41596-023-00825-8
pmc: PMC10293801
mid: NIHMS1906982
doi:
Substances chimiques
Copper
789U1901C5
Radiopharmaceuticals
0
Azides
0
Alkynes
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1659-1668Subventions
Organisme : NCI NIH HHS
ID : U01 CA221046
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA240963
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA204167
Pays : United States
Organisme : NCI NIH HHS
ID : R00 CA178205
Pays : United States
Informations de copyright
© 2023. Springer Nature Limited.
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