RAGE-TLR4 Crosstalk Is the Key Mechanism by Which High Glucose Enhances the Lipopolysaccharide-Induced Inflammatory Response in Primary Bovine Alveolar Macrophages.
Animals
Cattle
Cytokines
/ metabolism
Glucose
Glycation End Products, Advanced
Interleukin-6
/ metabolism
Lipopolysaccharides
/ toxicity
Macrophages, Alveolar
/ metabolism
Myeloid Differentiation Factor 88
/ genetics
NF-kappa B
/ metabolism
RNA, Messenger
Toll-Like Receptor 4
/ genetics
Tumor Necrosis Factor-alpha
/ genetics
Receptor for Advanced Glycation End Products
/ metabolism
TLR4–RAGE crosstalk
alveolar macrophages
glucose
inflammatory
lipopolysaccharide (LPS)
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
10 Apr 2023
10 Apr 2023
Historique:
received:
28
02
2023
revised:
04
04
2023
accepted:
06
04
2023
medline:
1
5
2023
pubmed:
28
4
2023
entrez:
28
4
2023
Statut:
epublish
Résumé
The receptor of advanced glycation end products (RAGE) and Toll-like receptor 4 (TLR4) are important receptors for inflammatory responses induced by high glucose (HG) and lipopolysaccharide (LPS) and show crosstalk phenomena in inflammatory responses. However, it is unknown whether RAGE and TLR4 can influence each other's expression through a crosstalk mechanism and whether the RAGE-TLR4 crosstalk related to the molecular mechanism of HG enhances the LPS-induced inflammatory response. In this study, the implications of LPS with multiple concentrations (0, 1, 5, and 10 μg/mL) at various treatment times (0, 3, 6, 12, and 24 h) in primary bovine alveolar macrophages (BAMs) were explored. The results showed that a 5 μg/mL LPS treatment at 12 h had the most significant increment on the pro-inflammatory cytokine interleukin 1β (IL-1β), IL-6, and tumor necrosis factor (TNF)-α levels in BAMs (
Identifiants
pubmed: 37108174
pii: ijms24087007
doi: 10.3390/ijms24087007
pmc: PMC10138623
pii:
doi:
Substances chimiques
Cytokines
0
Glucose
IY9XDZ35W2
Glycation End Products, Advanced
0
Interleukin-6
0
Lipopolysaccharides
0
Myeloid Differentiation Factor 88
0
NF-kappa B
0
RNA, Messenger
0
Toll-Like Receptor 4
0
Tumor Necrosis Factor-alpha
0
Receptor for Advanced Glycation End Products
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Key Research and Development project
ID : No.2021YFD1600200
Organisme : China Agriculture Research System of MOF and MARA
ID : Beef Cattle/Yak, CARS-37
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