Sweat Testing for the Detection of Methylone after Controlled Administrations in Humans.
LC-MS/MS
methylone
pharmacokinetics
sweat
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
17 Apr 2023
17 Apr 2023
Historique:
received:
20
03
2023
revised:
02
04
2023
accepted:
14
04
2023
medline:
1
5
2023
pubmed:
28
4
2023
entrez:
28
4
2023
Statut:
epublish
Résumé
The aim of this study was to determine the excretion of methylone and its metabolites in sweat following the ingestion of increasing controlled doses of 50, 100, 150 and 200 mg of methylone to twelve healthy volunteers involved in a clinical trial. Methylone and its metabolites 4-hydroxy-3-methoxy-N-methylcathinone (HMMC) and 3,4-methylenedioxycathinone (MDC) were analyzed in sweat patches by liquid chromatography-tandem mass spectrometry. Methylone and MDC were detected in sweat at 2 h and reached their highest accumulation (C
Identifiants
pubmed: 37108557
pii: ijms24087395
doi: 10.3390/ijms24087395
pmc: PMC10138602
pii:
doi:
Substances chimiques
Methamphetamine
44RAL3456C
methylone
L4I4B1R01F
Types de publication
Clinical Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Italian Department of antidrug Policies
ID : no number
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