The Clinical Study of Anti TPO Antibodies in Patients of Type 1 Diabetes Mellitus.

The association of Type 1 diabetes mellitus with autoimmune thyroid disease (AITD) has been well documented in many populations. The appearance of Anti TPO antibodies precedes thyroid dysfunction and increase in autoimmune diseases like type 1 diabetes. The occurrence of thyroid auto antibodies against microsomes (AMA) and thyroglobulin (ATA), frequently seen in Hashimoto's thyroiditis and Grave's disease have been reported in type 1 diabetes mellitus with varying frequency. The present study was carried out at tertiary care centre. Prospective study. Duration of study: October 2014 to December 2015. 60 patients. In the present study, out of 60 patients 32 (53.33%) patients were female and 28 (46.66%) were male. Out of 60 patients, 10 patients had positive titre for Anti TPO antibodies. Out of 10 patients, 6 patients were female and 4 patients were male. Anti TPO antibodies level was elevated in 10 (16.66%) patients. Out of 10 patients, 6 (60%) patients were female and 4 (40%) were male. 6 out of 10 (60%) Anti TPO positive patients had longer duration of DM1. Patients having raised Anti TPO antibodies had no relation between Anti TPO antibodies and RBS level. Though HbA1c was high in Anti TPO antibodies positive patients statistically it was not significant. Patients having raised Anti TPO antibodies level had normal TSH level.

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© Journal of the Association of Physicians of India 2011.