An interactive murine single-cell atlas of the lung responses to radiation injury.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
28 04 2023
28 04 2023
Historique:
received:
29
07
2022
accepted:
17
04
2023
medline:
1
5
2023
pubmed:
29
4
2023
entrez:
28
4
2023
Statut:
epublish
Résumé
Radiation Induced Lung Injury (RILI) is one of the main limiting factors of thorax irradiation, which can induce acute pneumonitis as well as pulmonary fibrosis, the latter being a life-threatening condition. The order of cellular and molecular events in the progression towards fibrosis is key to the physiopathogenesis of the disease, yet their coordination in space and time remains largely unexplored. Here, we present an interactive murine single cell atlas of the lung response to irradiation, generated from C57BL6/J female mice. This tool opens the door for exploration of the spatio-temporal dynamics of the mechanisms that lead to radiation-induced pulmonary fibrosis. It depicts with unprecedented detail cell type-specific radiation-induced responses associated with either lung regeneration or the failure thereof. A better understanding of the mechanisms leading to lung fibrosis will help finding new therapeutic options that could improve patients' quality of life.
Identifiants
pubmed: 37117166
doi: 10.1038/s41467-023-38134-z
pii: 10.1038/s41467-023-38134-z
pmc: PMC10147670
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2445Informations de copyright
© 2023. The Author(s).
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