NMR resonance assignment of a fibroblast growth factor 8 splicing isoform b.
Dynamics
FGF
FGF8
FGF8b
FGFR
Fibroblast growth factor
Fibroblast growth factor receptor.
Motions
Structure
Journal
Biomolecular NMR assignments
ISSN: 1874-270X
Titre abrégé: Biomol NMR Assign
Pays: Netherlands
ID NLM: 101472371
Informations de publication
Date de publication:
06 2023
06 2023
Historique:
received:
21
02
2023
accepted:
24
04
2023
medline:
2
6
2023
pubmed:
29
4
2023
entrez:
28
4
2023
Statut:
ppublish
Résumé
The splicing isoform b of human fibroblast growth factor 8 (FGF8b) is an important regulator of brain embryonic development. Here, we report the almost complete NMR chemical shift assignment of the backbone and aliphatic side chains of FGF8b. Obtained chemical shifts are in good agreement with the previously reported X-ray data, excluding the N-terminal gN helix, which apparently forms only in complex with the receptor. The reported data provide an NMR starting point for the investigation of FGF8b interaction with its receptors and with potential drugs or inhibitors.
Identifiants
pubmed: 37118562
doi: 10.1007/s12104-023-10132-8
pii: 10.1007/s12104-023-10132-8
pmc: PMC10232571
doi:
Substances chimiques
Fibroblast Growth Factor 8
148997-75-5
Protein Isoforms
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
135-142Informations de copyright
© 2023. The Author(s).
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