The role of high cholesterol in SARS-CoV-2 infectivity.

Animals Mice COVID-19 SARS-CoV-2 / metabolism Angiotensin-Converting Enzyme 2 Peptidyl-Dipeptidase A / metabolism Hypercholesterolemia Cholesterol / metabolism Spike Glycoprotein, Coronavirus / metabolism Mammals / metabolism
COVID-19 GM1 PIP2 STORM aging apoE cholesterol diabetes furin imaging lipid membrane lipid raft obesity palmitoylation

Journal

The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R

Informations de publication

Date de publication:
06 2023
Historique:
received: 30 03 2023
revised: 11 04 2023
accepted: 24 04 2023
medline: 28 6 2023
pubmed: 30 4 2023
entrez: 29 4 2023
Statut: ppublish

Résumé

Coronavirus disease 2019 (COVID-19) is a respiratory infection caused by severe acute respiratory syndrome coronavirus 2. The virus binds to angiotensinogen converting enzyme 2 (ACE2), which mediates viral entry into mammalian cells. COVID-19 is notably severe in the elderly and in those with underlying chronic conditions. The cause of selective severity is not well understood. Here we show cholesterol and the signaling lipid phosphatidyl-inositol 4,5 bisphosphate (PIP

Identifiants

DOI: 10.1016/j.jbc.2023.104763 PMID: 37119851 PMC: PMC10140059
pubmed: 37119851
pii: S0021-9258(23)01791-X
doi: 10.1016/j.jbc.2023.104763
pmc: PMC10140059
pii:
doi:

Substances chimiques

Angiotensin-Converting Enzyme 2 EC 3.4.17.23
Peptidyl-Dipeptidase A EC 3.4.15.1
Cholesterol 97C5T2UQ7J
Spike Glycoprotein, Coronavirus 0
spike protein, SARS-CoV-2 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

104763

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS112534
Pays : United States

Commentaires et corrections

Type : UpdateOf

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest The authors declare that they have no conflicts of interest with the contents of this article.

Auteurs

Hao Wang (H)

Department of Molecular Medicine, The Scripps Research Institute, Jupiter, Florida, USA; Department of Neuroscience, The Scripps Research Institute, Jupiter, Florida, USA; Skaggs Graduate School of Chemical and Biological Sciences, The Scripps Research Institute, Jupiter, Florida, USA.

Zixuan Yuan (Z)

Department of Molecular Medicine, The Scripps Research Institute, Jupiter, Florida, USA; Department of Neuroscience, The Scripps Research Institute, Jupiter, Florida, USA; Skaggs Graduate School of Chemical and Biological Sciences, The Scripps Research Institute, Jupiter, Florida, USA.

Mahmud Arif Pavel (MA)

Department of Molecular Medicine, The Scripps Research Institute, Jupiter, Florida, USA; Department of Neuroscience, The Scripps Research Institute, Jupiter, Florida, USA.

Sonia Mediouni Jablonski (SM)

Department of Immunology and Virology, The Scripps Research Institute, Jupiter, Florida, USA.

Joseph Jablonski (J)

Department of Immunology and Virology, The Scripps Research Institute, Jupiter, Florida, USA.

Robert Hobson (R)

Bruker Nano Surfaces, Fitchburg, Wisconsin, USA; Department of Biology, University of Utah, Salt Lake City, Utah, USA.

Susana Valente (S)

Department of Immunology and Virology, The Scripps Research Institute, Jupiter, Florida, USA.

Chakravarthy B Reddy (CB)

Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah, USA.

Scott B Hansen (SB)

Department of Molecular Medicine, The Scripps Research Institute, Jupiter, Florida, USA; Department of Neuroscience, The Scripps Research Institute, Jupiter, Florida, USA. Electronic address: shansen@scripps.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The role of high cholesterol in SARS-CoV-2 infectivity.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The role of high cholesterol in SARS-CoV-2 infectivity.
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › The role of high cholesterol in SARS-CoV-2 infectivity.
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › The role of high cholesterol in SARS-CoV-2 infectivity.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Exopeptidases › Carboxypeptidases › Angiotensin-converting enzyme 2 › The role of high cholesterol in SARS-CoV-2 infectivity.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Exopeptidases › Dipeptidyl-Peptidases and Tripeptidyl-Peptidases › Peptidyl-Dipeptidase A › The role of high cholesterol in SARS-CoV-2 infectivity.
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles du métabolisme lipidique › Dyslipidémies › Hyperlipidémies › Hypercholestérolémie › The role of high cholesterol in SARS-CoV-2 infectivity.
questionsmedicales.fr › Lipides › Lipides membranaires › Stérols › Cholestérol › The role of high cholesterol in SARS-CoV-2 infectivity.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales structurales › Protéines de l'enveloppe virale › Protéines de fusion virale › Glycoprotéine de spicule des coronavirus › The role of high cholesterol in SARS-CoV-2 infectivity.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › The role of high cholesterol in SARS-CoV-2 infectivity.