Clinical features, treatment and outcome of pediatric patients with severe cutaneous manifestations in IgA vasculitis: Multicenter international study.
Glucocorticoids
Henoch-Schönlein Purpura
IgA vasculitis
Nephritis
Severe cutaneous manifestations
Journal
Seminars in arthritis and rheumatism
ISSN: 1532-866X
Titre abrégé: Semin Arthritis Rheum
Pays: United States
ID NLM: 1306053
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
received:
03
11
2022
revised:
14
04
2023
accepted:
19
04
2023
medline:
10
7
2023
pubmed:
2
5
2023
entrez:
1
5
2023
Statut:
ppublish
Résumé
IgA vasculitis (IgAV) (formerly Henoch-Schönlein Purpura, HSP) rarely causes severe skin lesions in children. The purpose of the research was to determine whether severe skin manifestations were associated with a more severe disease course. Severe cutaneous manifestations were defined as presence of hemorrhagic vesicles, bullae, ulcerations and/or necroses. Data were collected retrospectively from 12 international tertiary university medical centers. A total of 64 patients with the most severe skin changes in IgAV/HSP and median (Q Patients with IgAV/HSP and severe skin manifestations had a more severe clinical course and more frequently required glucocorticoids compared to classic IgAV/HSP patients.
Identifiants
pubmed: 37126983
pii: S0049-0172(23)00051-3
doi: 10.1016/j.semarthrit.2023.152209
pii:
doi:
Substances chimiques
Glucocorticoids
0
Immunoglobulin A
0
Types de publication
Multicenter Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
152209Informations de copyright
Copyright © 2023. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare no conflicts of interest.