Molecular mechanisms underlying adverse effects of dexamethasone and betamethasone in the developing cardiovascular system.
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484
Informations de publication
Date de publication:
06 2023
06 2023
Historique:
revised:
02
03
2023
received:
07
05
2022
accepted:
09
03
2023
medline:
4
5
2023
pubmed:
3
5
2023
entrez:
3
5
2023
Statut:
ppublish
Résumé
Antenatal glucocorticoids accelerate fetal lung maturation and reduce mortality in preterm babies but can trigger adverse effects on the cardiovascular system. The mechanisms underlying off-target effects of the synthetic glucocorticoids mostly used, Dexamethasone (Dex) and Betamethasone (Beta), are unknown. We investigated effects of Dex and Beta on cardiovascular structure and function, and underlying molecular mechanism using the chicken embryo, an established model system to isolate effects of therapy on the developing heart and vasculature, independent of effects on the mother or placenta. Fertilized eggs were treated with Dex (0.1 mg kg
Identifiants
pubmed: 37132324
doi: 10.1096/fj.202200676RR
doi:
Substances chimiques
Betamethasone
9842X06Q6M
Glucocorticoids
0
Dexamethasone
7S5I7G3JQL
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e22887Subventions
Organisme : British Heart Foundation
ID : PG/10/99/28656
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/17/8/32924
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/17/12/33167
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/12/74/29778
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/11/16/29260
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00014/4
Pays : United Kingdom
Informations de copyright
© 2023 The Authors. The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology.
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