Emerging roles of SARS-CoV-2 Spike-ACE2 in immune evasion and pathogenesis.
ACE2
COVID-19
SARS-CoV-2
cytotoxic T cell
immunological synapse
spike
Journal
Trends in immunology
ISSN: 1471-4981
Titre abrégé: Trends Immunol
Pays: England
ID NLM: 100966032
Informations de publication
Date de publication:
06 2023
06 2023
Historique:
received:
28
01
2023
revised:
23
03
2023
accepted:
03
04
2023
medline:
29
5
2023
pubmed:
4
5
2023
entrez:
3
5
2023
Statut:
ppublish
Résumé
The COVID-19 pandemic, caused by SARS-CoV-2, has caused an estimated 5 billion infections and 20 million deaths by respiratory failure. In addition to the respiratory disease, SARS-CoV-2 infection has been associated with many extrapulmonary complications not easily explainable by the respiratory infection. A recent study showed that the SARS-CoV-2 spike protein, which mediates cell entry by binding to the angiotensin-converting enzyme 2 (ACE2) receptor, signals through ACE2 to change host cell behavior. In CD8
Identifiants
pubmed: 37137805
pii: S1471-4906(23)00057-1
doi: 10.1016/j.it.2023.04.001
pmc: PMC10076505
pii:
doi:
Substances chimiques
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
spike protein, SARS-CoV-2
0
ACE2 protein, human
EC 3.4.17.23
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
424-434Subventions
Organisme : European Research Council
ID : 951329
Pays : International
Informations de copyright
Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests No interests are declared.