Ovulatory-cycle frozen embryo transfer: spontaneous or triggered ovulation and the impact of LH elevation at hCG triggering.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
03 05 2023
03 05 2023
Historique:
received:
27
05
2022
accepted:
22
04
2023
medline:
5
5
2023
pubmed:
4
5
2023
entrez:
3
5
2023
Statut:
epublish
Résumé
The effect of the luteinizing hormone (LH) elevation before the human chorionic gonadotropin (hCG) trigger in ovulatory frozen-thawed embryo transfer (Ovu-FET) cycles has not been determined. We aimed to investigate whether triggering ovulation in Ovu-FET cycles affects the live birth rate (LBR), and the contribution of elevated LH at the time of hCG trigger. This retrospective study included Ovu-FET cycles performed in our center from August 2016 to April 2021. Modified Ovu-FET (hCG trigger) and true Ovu-FET (without hCG trigger) were compared. The modified group was divided according to whether hCG was administered, before or after LH increased to > 15 IU/L and was twice the baseline value. The modified (n = 100) and true (n = 246) Ovu-FET groups and both subgroups of the modified Ovu-FET, those who were triggered before (n = 67) or after (n = 33) LH elevation, had comparable characteristics at baseline. Comparison of true vs. modified Ovu-FET outcomes revealed similar LBR (35.4% vs. 32.0%; P = 0.62), respectively. LBR were similar between the modified Ovu-FET subgroups regardless of the hCG trigger timing (31.3% before vs. 33.3% after LH elevation; P = 0.84). In conclusion, LBR of Ovu-FET were not affected by hCG trigger or whether LH was elevated at the time of hCG trigger. These results add reassurance regarding hCG triggering even after LH elevation.
Identifiants
pubmed: 37137911
doi: 10.1038/s41598-023-34017-x
pii: 10.1038/s41598-023-34017-x
pmc: PMC10156802
doi:
Substances chimiques
Luteinizing Hormone
9002-67-9
Chorionic Gonadotropin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
7195Informations de copyright
© 2023. The Author(s).
Références
Int J Mol Sci. 2019 Dec 18;21(1):
pubmed: 31861484
Hum Reprod. 2016 Oct;31(10):2231-44
pubmed: 27609980
Reprod Biomed Online. 2021 Mar;42(3):529-545
pubmed: 33384269
Reprod Biomed Online. 2009 Jul;19(1):66-71
pubmed: 19573293
Gynecol Obstet Invest. 2007;64(3):156-60
pubmed: 17934312
Hum Reprod. 2011 Jun;26(6):1270-83
pubmed: 21502182
J Assist Reprod Genet. 2020 Dec;37(12):3025-3031
pubmed: 33057910
Hum Reprod Open. 2020 May 01;2020(2):hoaa009
pubmed: 32395637
Fertil Steril. 2010 Nov;94(6):2054-8
pubmed: 20097333
J Assist Reprod Genet. 2011 Apr;28(4):369-74
pubmed: 21229386
J Assist Reprod Genet. 2018 Sep;35(9):1703-1712
pubmed: 29974367
Cochrane Database Syst Rev. 2017 Jul 05;7:CD003414
pubmed: 28675921
Hum Reprod. 2022 Jun 30;37(7):1619-1641
pubmed: 35553678
Hum Reprod. 2018 Sep 1;33(9):1586-1601
pubmed: 30032255
J Clin Med. 2021 Feb 11;10(4):
pubmed: 33670133
Biomed Res Int. 2014;2014:307268
pubmed: 24779007
Hum Reprod. 2017 Nov 1;32(11):2234-2242
pubmed: 29025055
Fertil Steril. 2012 Nov;98(5):1165-9
pubmed: 22840239
Hum Reprod. 2017 May 1;32(5):1019-1027
pubmed: 28333318
J Ovarian Res. 2017 Oct 16;10(1):70
pubmed: 29037231
Fertil Steril. 2011 May;95(6):1985-9
pubmed: 21411078
Am J Obstet Gynecol. 2019 Apr;220(4):379.e1-379.e7
pubmed: 30521800
Fertil Steril. 2000 Jun;73(6):1155-8
pubmed: 10856474
Reprod Biomed Online. 2012 Feb;24(2):191-6
pubmed: 22197128
Reprod Sci. 2021 Jul;28(7):1874-1881
pubmed: 33140324
Hum Reprod. 2018 Dec 1;33(12):2212-2221
pubmed: 30304457
Reprod Biomed Online. 2011 Oct;23(4):484-9
pubmed: 21840758
Am J Obstet Gynecol MFM. 2023 Jan;5(1):100752
pubmed: 36115572
Hum Reprod. 2020 May 1;35(5):1073-1081
pubmed: 32395750