A new method based on dispersive liquid-liquid microextraction for fat-soluble vitamin determination in serum by LC-MS/MS.
LC-MS/MS
dispersive liquid-liquid microextraction
fat-soluble vitamins
serum
Journal
Biomedical chromatography : BMC
ISSN: 1099-0801
Titre abrégé: Biomed Chromatogr
Pays: England
ID NLM: 8610241
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
revised:
18
04
2023
received:
21
11
2022
accepted:
25
04
2023
medline:
16
8
2023
pubmed:
4
5
2023
entrez:
4
5
2023
Statut:
ppublish
Résumé
A green and inexpensive pretreatment known as dispersive liquid-liquid microextraction (DLLME) was developed in this assay coupled with the LC-MS/MS method for routine analysis of fat soluble vitamins (FSVs). The technique was performed with methanol as the dispersive solvent and dichloromethane as the extraction solvent. The extraction phase containing FSVs was evaporated to dryness and reconstituted in a mixture of acetonitrile and water. The influence variables concerning the DLLME procedure were optimized. After that, the method was investigated for its applicability in LC-MS/MS analysis. As a result, the parameters were settled for the optimal conditions during the DLLME process. A cheap and lipid-free substance was found as an alternative to serum to eliminate the matrix effect while preparing the calibrators. The method validation indicated that it was suitable for determining FSVs in serum. Moreover, this method was applied successfully to determine serum samples, which was consistent with the literature. In summary, the DLLME method developed in this report was reliable and more cost-effective than the traditional LC-MS/MS method, and could be applied in the future.
Substances chimiques
Solvents
0
Vitamins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e5666Subventions
Organisme : Hangzhou Biozon Medical Device Co. Ltd
Organisme : Hangzhou Biozon Medical Laboratory
Organisme : Key R&D Program of Zhejiang Province
ID : 2021C03088
Informations de copyright
© 2023 John Wiley & Sons Ltd.
Références
Ahmad, W., Al-Sibaai, A. A., Bashammakh, A. S., Alwael, H., & El-Shahawi, M. S. (2015). Recent advances in dispersive liquid-liquid microextraction for pesticide analysis. TrAC, Trends in AnalyticalChemistry, 72, 181-192. https://doi.org/10.1016/j.trac.2015.04.022
Ahmed, S. G., & Khayoon, W. S. (2022). A solvent collection technique using dispersive liquid-liquid microextraction coupled with spectrophotometry for the trace determination of folic acid in pure, dosage forms and flaxseed. Chemical Papers, 76(4), 2485-2494. https://doi.org/10.1007/s11696-021-02027-6
Albahrani, A. A., Rotarou, V., Roche, P. J., & Greaves, R. F. (2016). A simultaneous quantitative method for vitamins A, D and E in human serum using liquid chromatography-tandem mass spectrometry. Journal of Steroid Biochemistry and Molecular Biology, 159, 41-53. https://doi.org/10.1016/j.jsbmb.2016.02.019
Andreoli, R., Manini, P., Poli, D., Bergamaschi, E., Mutti, A., & Niessen, W. M. A. (2004). Development of a simplified method for the simultaneous determination of retinol, -tocopherol, and -carotene in serum by liquid chromatography-tandem mass spectrometry with atmospheric pressure chemical ionization. Analytical and Bioanalytical Chemistry, 378(4), 987-994. https://doi.org/10.1007/s00216-003-2288-0
Capote, F. P., Jiménez, J. R., Granados, J. M. M., & De Castro, M. D. L. (2007). Identification and determination of fat-soluble vitamins and metabolites in human serum by liquid chromatography/triple quadrupole mass spectrometry with multiple reaction monitoring. Rapid Communications in Mass Spectrometry, 21(11), 1745-1754. https://doi.org/10.1002/rcm.3014
Chang, S. W., & Lee, H. C. (2019). Vitamin D and health-The missing vitamin in humans. Pediatrics and Neonatology, 60(3), 237-244. https://doi.org/10.1016/j.pedneo.2019.04.007
CLSI. (2005). Interference testing in clinical chemistry; approved guideline-second edition. In CLSI document EP07-A3 (Vol. 25).
Cornell, L., Arita, K., & Goodrich, R. (2021). Fat-soluble vitamins: A, E, and K. In Geriatric gastroenterology (pp. 631-651). Springer. https://doi.org/10.1007/978-3-030-30192-7
Ding, S., Schoenmakers, I., Jones, K., Koulman, A., Prentice, A., & Volmer, D. A. (2010). Quantitative determination of vitamin D metabolites in plasma using UHPLC-MS/MS. Analytical and Bioanalytical Chemistry, 398(2), 779-789. https://doi.org/10.1007/s00216-010-3993-0
Ertugrul, S., Yucel, C., Sertoglu, E., Ozkan, Y., & Ozgurtas, T. (2020). Development and optimization of simultaneous determination of fat soluble vitamins by liquid chromatography tandem mass spectrometry. Chemistry and Physics of Lipids, 230(June), 104932. https://doi.org/10.1016/j.chemphyslip.2020.104932
Gałuszka, A., Migaszewski, Z., & Namieśnik, J. (2013). The 12 principles of green analytical chemistry and the SIGNIFICANCE mnemonic of green analytical practices. TrAC, Trends in Analytical Chemistry, 50, 78-84. https://doi.org/10.1016/j.trac.2013.04.010
Ghalebi, M., Tamizi, E., Ahmadi, S., Sheikhloo, A., & Nemati, M. (2019). Dispersive liquid-liquid micro-extraction technique for the pre-concentration and quantification of vitamin D3 in milk and yogurt samples using a non-aqueous HPLC method. Iranian Journal of Pharmaceutical Research, 18(2), 677-685. https://doi.org/10.22037/ijpr.2019.1100634
Hinchliffe, E., Rudge, J., & Reed, P. (2016). A novel high-throughput method for supported liquid extraction of retinol and alpha-tocopherol from human serum and simultaneous quantitation by liquid chromatography tandem mass spectrometry. Annals of Clinical Biochemistry, 53(4), 434-445. https://doi.org/10.1177/0004563215596024
Jeon, S. M., & Shin, E. A. (2018). Exploring vitamin D metabolism and function in cancer. Experimental and Molecular Medicine, 50(4), 1-14. https://doi.org/10.1038/s12276-018-0038-9
Johnson-Davis, K. L., Moore, S. J., Owen, W. E., Cutler, J. M., & Frank, E. L. (2009). A rapid HPLC method used to establish pediatric reference intervals for vitamins A and E. Clinica Chimica Acta, 405(1-2), 35-38. https://doi.org/10.1016/j.cca.2009.03.058
Ko, D. H., Jun, S. H., Nam, Y., Song, S. H., Han, M., Yun, Y. M., & Song, J. (2021). Multiplex LC-MS/MS for simultaneous determination of 25-hydroxyvitamin D, 24,25-dihydroxyvitamin D3, albumin, and vitamin D-binding protein with its isoforms: One-step estimation of bioavailable vitamin D and vitamin D metabolite ratio. Journal of Steroid Biochemistry and Molecular Biology, 206(September 2020), 105796. https://doi.org/10.1016/j.jsbmb.2020.105796
Kong, L., Wang, J., Gao, Q., Li, X., Zhang, W., Wang, P., Ma, L., & He, L. (2022). Simultaneous determination of fat-soluble vitamins and carotenoids in human serum using a nanostructured ionic liquid based microextraction method. Journal of Chromatography A, 1666, 462861. https://doi.org/10.1016/j.chroma.2022.462861
Liu, H., Wang, D. J., Wan, K. X., Zhang, J., Yuan, Z. J., Yu, C. W., Yang, J., & Zou, L. (2021). Simultaneous quantification of fat-soluble vitamins a, 25-hydroxylvitamin D and vitamin E in plasma from children using liquid chromatography coupled to Orbitrap mass spectrometry. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1177, 122795. https://doi.org/10.1016/j.jchromb.2021.122795
Miyazawa, T., Burdeos, G. C., Itaya, M., Nakagawa, K., & Miyazawa, T. (2019). Vitamin E: Regulatory redox interactions. IUBMB Life, 71(4), 430-441. https://doi.org/10.1002/iub.2008
Oh, J., Choi, R., Park, H. D., Lee, H., Jeong, B. H., Park, H. Y., Jeon, K., Kwon, O. J., Koh, W. J., & Lee, S. Y. (2017). Evaluation of vitamin status in patients with pulmonary tuberculosis. Journal of Infection, 74(3), 272-280. https://doi.org/10.1016/j.jinf.2016.10.009
Prosen, H., & Zupančič-Kralj, L. (1999). Solid-phase microextraction. TrAC, Trends in Analytical Chemistry, 18(4), 272-282. https://doi.org/10.1016/S0165-9936(98)00109-5
Rezaee, M., Assadi, Y., Milani Hosseini, M. R., Aghaee, E., Ahmadi, F., & Berijani, S. (2006). Determination of organic compounds in water using dispersive liquid-liquid microextraction. Journal of Chromatography a, 1116(1-2), 1-9. https://doi.org/10.1016/j.chroma.2006.03.007
Rola, R., Bieńkowski, T., Kołodyńska-Goworek, A., & Studzińska, S. (2019). Development of a method for multiple vitamin D metabolite measurements by liquid chromatography coupled with tandem mass spectrometry in dried blood spots. The Analyst, 144, 299-309. https://doi.org/10.1039/c8an01422a
Rola, R., Kowalski, K., Bieńkowski, T., & Studzińska, S. (2020). Improved sample preparation method for fast LC-MS/MS analysis of vitamin D metabolites in serum. Journal of Pharmaceutical and Biomedical Analysis, 190, 113529. https://doi.org/10.1016/j.jpba.2020.113529
Rola, R., Kowalski, K., Bieńkowski, T., Witwicki, J., & Studzińska, S. (2021). Evaluation of different biological matrices to assess the vitamin D status in newborns using LC-MS/MS. Microchemical Journal, 168(May), 106368. https://doi.org/10.1016/j.microc.2021.106368
Siluk, D., Oliveira, R. V., Esther-Rodriguez-Rosas, M., Ling, S., Bos, A., Ferrucci, L., & Wainer, I. W. (2007). A validated liquid chromatography method for the simultaneous determination of vitamins A and E in human plasma. Journal of Pharmaceutical and Biomedical Analysis, 44(4), 1001-1007. https://doi.org/10.1016/j.jpba.2007.03.033
Sinaci, S., Ocal, D. F., Yucel Yetiskin, D. F., Uyan Hendem, D., Buyuk, G. N., Goncu Ayhan, S., Tanacan, A., Ozgu-Erdinc, A. S., Moraloglu Tekin, O., & Sahin, D. (2021). Impact of vitamin D on the course of COVID-19 during pregnancy: A case control study. Journal of Steroid Biochemistry and Molecular Biology, 213(9), 105964. https://doi.org/10.1016/j.jsbmb.2021.105964
Thibeault, D., Caron, N., Djiana, R., Kremer, R., & Blank, D. (2012). Development and optimization of simplified LC-MS/MS quantification of 25-hydroxyvitamin D using protein precipitation combined with on-line solid phase extraction (SPE). Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 883-884, 120-127. https://doi.org/10.1016/j.jchromb.2011.12.021
Trufelli, H., Palma, P., Famiglini, G., & Cappiello, A. (2011). An overview of matrix effects in liquid chromatography-mass spectrometry. Mass Spectrometry Reviews, 30(3), 491-509. https://doi.org/10.1002/mas.20298
Yin, S., Yang, Y., Wu, L., Li, Y., & Sun, C. (2019). Recent advances in sample preparation and analysis methods for vitamin D and its analogues in different matrices. TrAC, Trends in Analytical Chemistry, 110, 204-220. https://doi.org/10.1016/j.trac.2018.11.008
Zhang, Y., Lin, Y., Yang, X., Chen, G., Li, L., Ma, Y., & Liang-Schenkelberg, J. (2021). Fast determination of vitamin a, vitamin D and vitamin E in food by online SPE combined with heart-cutting two dimensional liquid chromatography. Journal of Food Composition and Analysis, 101(November 2020), 103983. https://doi.org/10.1016/j.jfca.2021.103983