The prevalence of abnormal right ventricle speckle strain in the setting of acute myocarditis and preserved left ventricle function.
Echocardiography
Myocarditis
RV4CLS
RVFWLS
Right ventricle
Strain
Journal
The international journal of cardiovascular imaging
ISSN: 1875-8312
Titre abrégé: Int J Cardiovasc Imaging
Pays: United States
ID NLM: 100969716
Informations de publication
Date de publication:
Jul 2023
Jul 2023
Historique:
received:
02
12
2022
accepted:
03
03
2023
medline:
12
6
2023
pubmed:
7
5
2023
entrez:
7
5
2023
Statut:
ppublish
Résumé
Acute myocarditis has a wide spectrum of clinical presentation, from subclinical disease to acute heart failure, and sudden cardiac death. Two-dimensional speckle tracking echocardiography (2D-STE) has been proven effective in early diagnosis of subclinical cardiac injury, however, there is a limited data regarding the right ventricle (RV) involvement among patients with acute myocarditis. We evaluated the prevalence of early subclinical RV injury assessed by 2D-STE, among patients with acute myocarditis and preserved left ventricle (LV) function. We performed a retrospective single-center study at Tel-Aviv Sourasky Medical Center, including all adult patients hospitalized with acute myocarditis, who presented with preserved LV function. 2D-STE analysis of the RV was performed offline, assessing both the RV four-chamber longitudinal strain peak systolic (RV4CLS PK) and the free wall longitudinal strain peak systolic (RVFWLS PK). The myocarditis group was compared to a healthy control group. From 2011 to 2020, a total of 90 patients included in the study and were compared to 70 healthy subjects. RV 2D-STE emerged as significantly lower for both the RV4CLS PK (-21.8 ± 4.2 vs. -24.9 ± 4.8, P < 0.001) and RVFWLS PK (-24.7 ± 4.9 vs. -28.4 ± 5, P < 0.001), and remained significant in a multivariate analysis. We presented for the first time the presence of subclinical RV dysfunction, assessed by 2D-STE, in patients diagnosed with acute myocarditis, in the presence of preserved LV function. Further studies are needed to evaluate its' role in the development of LV dysfunction, heart failure and mortality.
Sections du résumé
BACKGROUND
BACKGROUND
Acute myocarditis has a wide spectrum of clinical presentation, from subclinical disease to acute heart failure, and sudden cardiac death. Two-dimensional speckle tracking echocardiography (2D-STE) has been proven effective in early diagnosis of subclinical cardiac injury, however, there is a limited data regarding the right ventricle (RV) involvement among patients with acute myocarditis.
PURPOSE
OBJECTIVE
We evaluated the prevalence of early subclinical RV injury assessed by 2D-STE, among patients with acute myocarditis and preserved left ventricle (LV) function.
METHODS
METHODS
We performed a retrospective single-center study at Tel-Aviv Sourasky Medical Center, including all adult patients hospitalized with acute myocarditis, who presented with preserved LV function. 2D-STE analysis of the RV was performed offline, assessing both the RV four-chamber longitudinal strain peak systolic (RV4CLS PK) and the free wall longitudinal strain peak systolic (RVFWLS PK). The myocarditis group was compared to a healthy control group.
RESULTS
RESULTS
From 2011 to 2020, a total of 90 patients included in the study and were compared to 70 healthy subjects. RV 2D-STE emerged as significantly lower for both the RV4CLS PK (-21.8 ± 4.2 vs. -24.9 ± 4.8, P < 0.001) and RVFWLS PK (-24.7 ± 4.9 vs. -28.4 ± 5, P < 0.001), and remained significant in a multivariate analysis.
CONCLUSION
CONCLUSIONS
We presented for the first time the presence of subclinical RV dysfunction, assessed by 2D-STE, in patients diagnosed with acute myocarditis, in the presence of preserved LV function. Further studies are needed to evaluate its' role in the development of LV dysfunction, heart failure and mortality.
Identifiants
pubmed: 37149840
doi: 10.1007/s10554-023-02829-7
pii: 10.1007/s10554-023-02829-7
pmc: PMC10163986
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1231-1238Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature B.V.
Références
Cooper LT (2009) Myocarditis. N Engl J Med 360:1526–1538
doi: 10.1056/NEJMra0800028
pubmed: 19357408
pmcid: 5814110
Kostakou PM, Kostopoulos VS, Tryfou ES, Giannaris VD, Rodis IE, Olympios CD, Kouris NT (2018) Subclinical left ventricular dysfunction and correlation with regional strain analysis in myocarditis with normal ejection fraction. A new diagnostic criterion. Int J Cardiol 259:116–121
doi: 10.1016/j.ijcard.2018.01.058
pubmed: 29579586
Cooper LT, Keren A, Sliwa K, Matsumori A, Mensah GA (2014) The global burden of myocarditis: part 1: a systematic literature review for the global burden of diseases, injuries, and risk factors 2010 study. Glob Heart 9:121–129
doi: 10.1016/j.gheart.2014.01.007
pubmed: 25432122
Hsu JJ, Ziaeian B, Fonarow GC (2017) Heart failure with mid-range (Borderline) Ejection Fraction: clinical implications and future directions. JACC Heart Fail 5:763–771
doi: 10.1016/j.jchf.2017.06.013
pubmed: 29032140
pmcid: 6668914
Luis SA, Pellikka PA (2018) Is Speckle Tracking Imaging Ready for Prime Time in current Echo Clinical Practice? Prog Cardiovasc Dis 61:437–445
doi: 10.1016/j.pcad.2018.11.001
pubmed: 30408468
Thavendiranathan P, Poulin F, Lim KD, Plana JC, Woo A, Marwick TH (2014) Use of myocardial strain imaging by echocardiography for the early detection of cardiotoxicity in patients during and after cancer chemotherapy: a systematic review. J Am Coll Cardiol 63:2751–2768
doi: 10.1016/j.jacc.2014.01.073
pubmed: 24703918
Carluccio E, Biagioli P, Lauciello R, Zuchi C, Mengoni A, Bardelli G, Alunni G, Gronda EG, Ambrosio G (2019) Superior Prognostic Value of Right Ventricular Free Wall compared to global longitudinal strain in patients with heart failure. J Am Soc Echocardiogr 32:836–844e1
doi: 10.1016/j.echo.2019.02.011
pubmed: 30979539
de Groote P, Millaire A, Foucher-Hossein C, Nugue O, Marchandise X, Ducloux G, Lablanche JM (1998) Right ventricular ejection fraction is an independent predictor of survival in patients with moderate heart failure. J Am Coll Cardiol 32:948–954
doi: 10.1016/S0735-1097(98)00337-4
pubmed: 9768716
Rudski LG, Lai WW, Afilalo J, Hua L, Handschumacher MD, Chandrasekaran K, Solomon SD, Louie EK, Schiller NB (2010) Guidelines for the echocardiographic Assessment of the right heart in adults: a report from the American Society of Echocardiography. Endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the canadian society of Echocardiography. J Am Soc Echocardiogr 23:685–713
doi: 10.1016/j.echo.2010.05.010
pubmed: 20620859
Baruch G, Rothschild E, Sadon S et al (2021) Evolution of right and left ventricle routine and speckle-tracking echocardiography in patients recovering from coronavirus disease 2019: a longitudinal study. Eur Heart J Cardiovasc Imaging. https://doi.org/10.1093/EHJCI/JEAB190
doi: 10.1093/EHJCI/JEAB190
Focardi M, Cameli M, Carbone SF, Massoni A, de Vito R, Lisi M, Mondillo S (2015) Traditional and innovative echocardiographic parameters for the analysis of right ventricular performance in comparison with cardiac magnetic resonance. Eur Heart J Cardiovasc Imaging 16:47–52
doi: 10.1093/ehjci/jeu156
pubmed: 25187607
Caforio ALP, Pankuweit S, Arbustini E et al (2013) Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur Heart J 34:2636–2648
doi: 10.1093/eurheartj/eht210
pubmed: 23824828
Nagueh SF, Smiseth OA, Appleton CP et al (2016) Recommendations for the evaluation of left ventricular diastolic function by Echocardiography: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr 29:277–314
doi: 10.1016/j.echo.2016.01.011
pubmed: 27037982
Lang RM, Bierig M, Devereux RB et al (2006) Recommendations for chamber quantification. Eur J Echocardiography 7:79–108
doi: 10.1016/j.euje.2005.12.014
Baruch G, Rothschild E, Kapusta L, Schwartz LA, Biner S, Aviram G, Ingbir M, Nachmany I, Keren G, Topilsky Y (2019) Impact of right ventricular dysfunction and end-diastolic pulmonary artery pressure estimated from analysis of tricuspid regurgitant velocity spectrum in patients with preserved ejection fraction. Eur Heart J Cardiovasc Imaging 20:446–454
doi: 10.1093/ehjci/jey116
pubmed: 30169769
Muraru D, Onciul S, Peluso D, Soriani N, Cucchini U, Aruta P, Romeo G, Cavalli G, Iliceto S, Badano LP (2016) Sex- and method-specific reference values for right ventricular strain by 2-Dimensional Speckle-Tracking Echocardiography. Circ Cardiovasc Imaging 9:e003866
doi: 10.1161/CIRCIMAGING.115.003866
pubmed: 26860970
Addetia K, Miyoshi T, Citro R et al (2021) Two-dimensional echocardiographic right ventricular size and systolic function measurements stratified by sex, Age, and ethnicity: results of the World Alliance of Societies of Echocardiography Study. J Am Soc Echocardiogr 34:1148–1157e1
doi: 10.1016/j.echo.2021.06.013
pubmed: 34274451
Koo TK, Li MY (2016) A Guideline of selecting and reporting Intraclass correlation coefficients for Reliability Research. J Chiropr Med 15:155–163
doi: 10.1016/j.jcm.2016.02.012
pubmed: 27330520
pmcid: 4913118
Koo TK, Li MY Cracking the Code: Providing Insight Into the Fundamentals of Research and Evidence-Based Practice A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research. J Chiropr Med 15:155–16320., Adler Y, Charron P, Imazio M et al (2016) 2015 ESC Guidelines for the diagnosis and management of pericardial diseases: The Task Force for the Diagnosis and Management of Pericardial Diseases of the European Society of Cardiology (ESC)Endorsed by: The European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2015 Nov 7;36(42):2921–2964
Adler Y, Charron P, Imazio M et al (2016) 2015 ESC Guidelines for the diagnosis and management of pericardial diseases: The Task Force for the Diagnosis and Management of Pericardial Diseases of the European Society of Cardiology (ESC)Endorsed by: The European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2015 Nov 7;36(42):2921–2964
Hiebert JB, Vacek J, Shah Z, Rahman F, Pierce JD (2019) Use of speckle tracking to assess heart failure with preserved ejection fraction. J Cardiol 74:397–402
doi: 10.1016/j.jjcc.2019.06.004
pubmed: 31303358
pmcid: 6764910
Luetkens JA, Petry P, Kuetting D, Dabir D, Schmeel FC, Homsi R, Schild HH, Thomas D (2018) Left and right ventricular strain in the course of acute myocarditis: a cardiovascular magnetic resonance study. RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren 190:722–732
doi: 10.1055/a-0585-0271
Potter E, Marwick TH (2018) Assessment of Left ventricular function by Echocardiography: the case for routinely adding global longitudinal strain to Ejection Fraction. JACC Cardiovasc Imaging 11:260–274
doi: 10.1016/j.jcmg.2017.11.017
pubmed: 29413646
Lee JH, Park JH (2018) Strain analysis of the right ventricle using two-dimensional Echocardiography. J Cardiovasc Imaging 26:111
doi: 10.4250/jcvi.2018.26.e11
pubmed: 30310878
pmcid: 6160817
Bieber S, Kraechan A, Hellmuth JC et al (2021 Jun) Left and right ventricular dysfunction in patients with COVID-19-associated myocardial injury. Infection 49(3):491–500
Tryfou ES, Kostakou PM, Chasikidis CG et al (2021) Biventricular myocardial function in Covid-19 recovered patients assessed by speckle tracking echocardiography: a prospective cohot echocardiography study. Int J Cardiovasc Imaging. Dec 23;38(5):995–1003
Vitarelli A, Mangieri E, Terzano C et al (2015) Three-dimensional echocardiography and 2D-3D speckle-tracking imaging in chronic pulmonary hypertension: diagnostic accuracy in detecting hemodynamic signs of right ventricular (RV) failure. J Am Heart Assoc. Mar 19;4(3)
Caspar T, Fichot M, Ohana M et al (2017 Aug) Late detection of left ventricular dysfunction using two-dimensional and Three-Dimensional Speckle-Tracking Echocardiography in Patinets with history of Nonsevere Acute Myocarditis. J Am Soc Echocardiogr 30(8):756–762
Aquaro GD, Negri F, de Luca A et al (2018) Role of right ventricular involvement in acute myocarditis, assessed by cardiac magnetic resonance. Int J Cardiol 271:359–365
doi: 10.1016/j.ijcard.2018.04.087
pubmed: 30045820