Skeletal muscle delimited myopathy and verapamil toxicity in SUR2 mutant mouse models of AIMS.


Journal

EMBO molecular medicine
ISSN: 1757-4684
Titre abrégé: EMBO Mol Med
Pays: England
ID NLM: 101487380

Informations de publication

Date de publication:
07 06 2023
Historique:
revised: 10 04 2023
received: 14 09 2022
accepted: 17 04 2023
medline: 8 6 2023
pubmed: 8 5 2023
entrez: 8 5 2023
Statut: ppublish

Résumé

ABCC9-related intellectual disability and myopathy syndrome (AIMS) arises from loss-of-function (LoF) mutations in the ABCC9 gene, which encodes the SUR2 subunit of ATP-sensitive potassium (K

Identifiants

pubmed: 37154692
doi: 10.15252/emmm.202216883
pmc: PMC10245035
doi:

Substances chimiques

Adenosine Triphosphate 8L70Q75FXE
Potassium Channels, Inwardly Rectifying 0
Sulfonylurea Receptors 0
Verapamil CJ0O37KU29
Abcc9 protein, mouse 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e16883

Subventions

Organisme : NHLBI NIH HHS
ID : R35 HL140024
Pays : United States
Organisme : NHLBI NIH HHS
ID : K99 HL150277
Pays : United States
Organisme : NHLBI NIH HHS
ID : R00 HL150277
Pays : United States

Informations de copyright

© 2023 The Authors. Published under the terms of the CC BY 4.0 license.

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Auteurs

Conor McClenaghan (C)

Center for the Investigation of Membrane Excitability Diseases, and Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, USA.
Center for Advanced Biotechnology and Medicine, and Departments of Pharmacology and Medicine, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, USA.

Maya A Mukadam (MA)

Center for the Investigation of Membrane Excitability Diseases, and Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, USA.

Jacob Roeglin (J)

Center for the Investigation of Membrane Excitability Diseases, and Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, USA.

Robert C Tryon (RC)

Center for the Investigation of Membrane Excitability Diseases, and Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, USA.

Manfred Grabner (M)

Department of Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.

Anamika Dayal (A)

Department of Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.

Gretchen A Meyer (GA)

Program in Physical Therapy, Departments of Orthopaedic Surgery, Neurology and Biomedical Engineering, Washington University School of Medicine, St. Louis, MO, USA.

Colin G Nichols (CG)

Center for the Investigation of Membrane Excitability Diseases, and Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, USA.

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Classifications MeSH