Synthesis, Computational Insights, and Evaluation of Novel Sigma Receptors Ligands.
S1R agonist
S1R antagonist
SR ligands
drug discovery
mechanical hypersensitivity
molecular modeling
sigma receptors
Journal
ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337
Informations de publication
Date de publication:
17 05 2023
17 05 2023
Historique:
medline:
18
5
2023
pubmed:
8
5
2023
entrez:
8
5
2023
Statut:
ppublish
Résumé
The development of diazabicyclo[4.3.0]nonane and 2,7-diazaspiro[3.5]nonane derivatives as sigma receptors (SRs) ligands is reported. The compounds were evaluated in S1R and S2R binding assays, and modeling studies were carried out to analyze the binding mode. The most notable compounds,
Identifiants
pubmed: 37155827
doi: 10.1021/acschemneuro.3c00074
pmc: PMC10197133
doi:
Substances chimiques
Ligands
0
nonane
T9W3VH6G10
Receptors, sigma
0
Alkanes
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1845-1858Références
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