Candida expansion in the gut of lung cancer patients associates with an ecological signature that supports growth under dysbiotic conditions.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
09 05 2023
09 05 2023
Historique:
received:
02
05
2022
accepted:
11
04
2023
medline:
11
5
2023
pubmed:
10
5
2023
entrez:
10
5
2023
Statut:
epublish
Résumé
Candida species overgrowth in the human gut is considered a prerequisite for invasive candidiasis, but our understanding of gut bacteria promoting or restricting this overgrowth is still limited. By integrating cross-sectional mycobiome and shotgun metagenomics data from the stool of 75 male and female cancer patients at risk but without systemic candidiasis, bacterial communities in high Candida samples display higher metabolic flexibility yet lower contributional diversity than those in low Candida samples. We develop machine learning models that use only bacterial taxa or functional relative abundances to predict the levels of Candida genus and species in an external validation cohort with an AUC of 78.6-81.1%. We propose a mechanism for intestinal Candida overgrowth based on an increase in lactate-producing bacteria, which coincides with a decrease in bacteria that regulate short chain fatty acid and oxygen levels. Under these conditions, the ability of Candida to harness lactate as a nutrient source may enable Candida to outcompete other fungi in the gut.
Identifiants
pubmed: 37160893
doi: 10.1038/s41467-023-38058-8
pii: 10.1038/s41467-023-38058-8
pmc: PMC10169812
doi:
Substances chimiques
Lactic Acid
33X04XA5AT
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2673Informations de copyright
© 2023. The Author(s).
Références
Nat Methods. 2016 Jul;13(7):581-3
pubmed: 27214047
Nat Commun. 2021 May 7;12(1):2560
pubmed: 33963193
Open Forum Infect Dis. 2017 Jul 08;4(3):ofx144
pubmed: 28852682
Genome Biol. 2004;5(10):R80
pubmed: 15461798
Microorganisms. 2020 Jan 31;8(2):
pubmed: 32023941
Curr Opin Microbiol. 2011 Aug;14(4):386-91
pubmed: 21802979
ISME J. 2013 Jul;7(7):1256-61
pubmed: 23677008
Sci Rep. 2020 Dec 8;10(1):21466
pubmed: 33293650
PLoS Pathog. 2010 May 27;6(5):e1000879
pubmed: 20523891
Bioinformatics. 2015 Mar 15;31(6):926-32
pubmed: 25398609
Microbiome. 2019 Mar 22;7(1):46
pubmed: 30902113
Clin Microbiol Infect. 2009 Jul;15(7):662-9
pubmed: 19614718
Int J Mol Sci. 2020 Dec 22;22(1):
pubmed: 33375194
J Hum Nutr Diet. 2021 Aug;34(4):645-655
pubmed: 33586805
Nucleic Acids Res. 2014 Jan;42(Database issue):D459-71
pubmed: 24225315
Proc Natl Acad Sci U S A. 2010 May 18;107(20):9352-7
pubmed: 20435915
Nat Rev Immunol. 2012 Nov;12(11):786-98
pubmed: 23059428
Microbiome. 2017 Nov 25;5(1):153
pubmed: 29178920
Nat Biotechnol. 2017 Jan;35(1):81-89
pubmed: 27893703
Nat Med. 2020 Jan;26(1):59-64
pubmed: 31907459
Curr Opin Microbiol. 2020 Aug;56:1-6
pubmed: 32599521
mBio. 2014 Sep 23;5(5):e01361-14
pubmed: 25249279
Nat Med. 2015 Jul;21(7):808-14
pubmed: 26053625
J Immunother Cancer. 2021 Apr;9(4):
pubmed: 33827906
Genomics Inform. 2019 Mar;17(1):e6
pubmed: 30929407
mBio. 2018 Nov 6;9(6):
pubmed: 30401779
Microbiome. 2017 Aug 1;5(1):87
pubmed: 28760163
Nat Microbiol. 2021 Dec;6(12):1505-1515
pubmed: 34764444
Sci Rep. 2019 Jun 20;9(1):8872
pubmed: 31222159
Science. 2013 Aug 2;341(6145):569-73
pubmed: 23828891
Crit Rev Microbiol. 2009;35(4):283-309
pubmed: 19821642
Front Microbiol. 2017 Nov 07;8:2114
pubmed: 29163406
Nat Commun. 2021 Oct 22;12(1):6151
pubmed: 34686660
mBio. 2018 Nov 6;9(6):
pubmed: 30401781
Nat Rev Dis Primers. 2018 May 11;4:18026
pubmed: 29749387
Nucleic Acids Res. 2019 Jan 8;47(D1):D259-D264
pubmed: 30371820
PLoS One. 2012;7(7):e39764
pubmed: 22844397
Nucleic Acids Res. 2018 Jan 9;46(1):11-24
pubmed: 29186518
Oncotarget. 2018 Apr 6;9(26):18224-18238
pubmed: 29719601
Trends Microbiol. 2016 May;24(5):402-413
pubmed: 26996765
Curr Opin Microbiol. 2020 Aug;56:7-15
pubmed: 32604030
Clin Microbiol Infect. 2019 Oct;25(10):1200-1212
pubmed: 31039444
PLoS Comput Biol. 2017 Nov 15;13(11):e1005852
pubmed: 29140991
Front Microbiol. 2017 Nov 15;8:2224
pubmed: 29187837
Virulence. 2013 Feb 15;4(2):119-28
pubmed: 23302789
Microbiome. 2018 Jan 15;6(1):12
pubmed: 29335027
PLoS Comput Biol. 2015 May 07;11(5):e1004226
pubmed: 25950956
Clin Infect Dis. 2018 Aug 1;67(4):564-572
pubmed: 29481599
Nat Microbiol. 2021 Jul;6(7):960-970
pubmed: 34168315
Genome Biol. 2021 Mar 30;22(1):93
pubmed: 33785070
Int J Mol Sci. 2014 Aug 15;15(8):14234-46
pubmed: 25196521
Gastroenterology. 2014 May;146(6):1477-88
pubmed: 24503128
FEMS Microbiol Ecol. 2020 Jan 1;96(1):
pubmed: 31769789
Sci Rep. 2020 Nov 12;10(1):19737
pubmed: 33184454
Sci Rep. 2020 May 8;10(1):7805
pubmed: 32385373
J Infect Dis. 1994 Apr;169(4):859-67
pubmed: 8133102
PLoS One. 2011;6(12):e28654
pubmed: 22194876
Curr Opin Immunol. 2014 Aug;29:16-22
pubmed: 24727150
Microbiome. 2020 Sep 12;8(1):133
pubmed: 32919472
Med Mal Infect. 2015 Jan-Feb;45(1-2):9-16
pubmed: 25684583
Curr Pharm Des. 2014;20(28):4565-9
pubmed: 24180411
Nat Methods. 2015 Oct;12(10):902-3
pubmed: 26418763
New Phytol. 2010 Apr;186(2):281-5
pubmed: 20409185
Eur J Haematol. 1998 Oct;61(4):250-4
pubmed: 9820631
mSphere. 2015 Nov 18;1(1):
pubmed: 27303684
mSystems. 2018 Jul 17;3(4):
pubmed: 30035234
BMC Bioinformatics. 2019 Jun 20;20(Suppl 12):314
pubmed: 31216991
Toxicol Pathol. 2017 Jan;45(1):134-145
pubmed: 27815489
Metabolites. 2019 Sep 21;9(10):
pubmed: 31546636
Curr Opin Microbiol. 2021 Aug;62:8-13
pubmed: 33993019
Nat Methods. 2018 Nov;15(11):962-968
pubmed: 30377376
mBio. 2018 Nov 6;9(6):
pubmed: 30401773
PLoS One. 2011;6(9):e24759
pubmed: 21931845
Nat Rev Immunol. 2013 Nov;13(11):790-801
pubmed: 24096337
Microbiome. 2018 Sep 1;6(1):152
pubmed: 30172257
Nat Microbiol. 2018 Apr;3(4):456-460
pubmed: 29531366
Nat Commun. 2022 Jun 9;13(1):3192
pubmed: 35680868
Nat Microbiol. 2016 Dec 12;2:16238
pubmed: 27941860
Gut Microbes. 2021 Jan-Dec;13(1):1993598
pubmed: 34793277
Nat Methods. 2010 May;7(5):335-6
pubmed: 20383131
Nat Methods. 2017 Apr;14(4):417-419
pubmed: 28263959
J Antimicrob Chemother. 2011 Nov;66(11):2573-80
pubmed: 21911344
Commun Biol. 2021 Oct 25;4(1):1220
pubmed: 34697386
Nucleic Acids Res. 2018 Sep 6;46(15):7542-7553
pubmed: 30192979
ISME J. 2017 Mar;11(3):676-690
pubmed: 27858930
Microbiology (Reading). 2017 Nov;163(11):1568-1577
pubmed: 28982395
J Fungi (Basel). 2020 Jan 13;6(1):
pubmed: 31940968
PLoS One. 2014 Jun 05;9(6):e99103
pubmed: 24901336
Biochem Biophys Rep. 2022 Jul 18;31:101314
pubmed: 35873654
ISME J. 2021 May;15(5):1257-1270
pubmed: 33323978
Science. 2018 Nov 30;362(6418):
pubmed: 30498100
Infect Immun. 2013 Jan;81(1):238-48
pubmed: 23115042