Skin basal cell carcinomas assemble a pro-tumorigenic spatially organized and self-propagating Trem2+ myeloid niche.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
10 05 2023
10 05 2023
Historique:
received:
26
10
2022
accepted:
07
04
2023
medline:
12
5
2023
pubmed:
11
5
2023
entrez:
10
5
2023
Statut:
epublish
Résumé
Cancer immunotherapies have revolutionized treatment but have shown limited success as single-agent therapies highlighting the need to understand the origin, assembly, and dynamics of heterogeneous tumor immune niches. Here, we use single-cell and imaging-based spatial analysis to elucidate three microenvironmental neighborhoods surrounding the heterogeneous basal cell carcinoma tumor epithelia. Within the highly proliferative neighborhood, we find that TREM2
Identifiants
pubmed: 37164949
doi: 10.1038/s41467-023-37993-w
pii: 10.1038/s41467-023-37993-w
pmc: PMC10172319
doi:
Substances chimiques
TREM2 protein, human
0
Membrane Glycoproteins
0
Receptors, Immunologic
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2685Subventions
Organisme : NIAMS NIH HHS
ID : T32 AR007422
Pays : United States
Organisme : NCI NIH HHS
ID : F32 CA254434
Pays : United States
Organisme : NCI NIH HHS
ID : K08 CA218893
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA260852
Pays : United States
Informations de copyright
© 2023. The Author(s).
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