Using light and X-ray scattering to untangle complex neuronal orientations and validate diffusion MRI.
X-ray scattering
brain connectivity
corona radiata
human
light scattering
neuroimaging
neuroscience
vervet monkey
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
11 05 2023
11 05 2023
Historique:
received:
07
10
2022
accepted:
02
05
2023
medline:
7
6
2023
pubmed:
11
5
2023
entrez:
11
5
2023
Statut:
epublish
Résumé
Disentangling human brain connectivity requires an accurate description of nerve fiber trajectories, unveiled via detailed mapping of axonal orientations. However, this is challenging because axons can cross one another on a micrometer scale. Diffusion magnetic resonance imaging (dMRI) can be used to infer axonal connectivity because it is sensitive to axonal alignment, but it has limited spatial resolution and specificity. Scattered light imaging (SLI) and small-angle X-ray scattering (SAXS) reveal axonal orientations with microscopic resolution and high specificity, respectively. Here, we apply both scattering techniques on the same samples and cross-validate them, laying the groundwork for ground-truth axonal orientation imaging and validating dMRI. We evaluate brain regions that include unidirectional and crossing fibers in human and vervet monkey brain sections. SLI and SAXS quantitatively agree regarding in-plane fiber orientations including crossings, while dMRI agrees in the majority of voxels with small discrepancies. We further use SAXS and dMRI to confirm theoretical predictions regarding SLI determination of through-plane fiber orientations. Scattered light and X-ray imaging can provide quantitative micrometer 3D fiber orientations with high resolution and specificity, facilitating detailed investigations of complex fiber architecture in the animal and human brain.
Identifiants
pubmed: 37166005
doi: 10.7554/eLife.84024
pii: 84024
pmc: PMC10259419
doi:
pii:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NINDS NIH HHS
ID : R01 NS088040
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB017183
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG061120
Pays : United States
Organisme : NIH HHS
ID : P40 OD010965
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30 GM133894
Pays : United States
Organisme : NIH HHS
ID : S10 OD021512
Pays : United States
Informations de copyright
© 2023, Menzel et al.
Déclaration de conflit d'intérêts
MM, DG, IR, MZ, MG No competing interests declared
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