Blood Metabolite Profiling of Antarctic Expedition Members: An
Antarctica
Concordia base
NMR
adaptation
hypoxia
metabolomics
winter-over
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
08 May 2023
08 May 2023
Historique:
received:
28
03
2023
revised:
03
05
2023
accepted:
05
05
2023
medline:
15
5
2023
pubmed:
13
5
2023
entrez:
13
5
2023
Statut:
epublish
Résumé
Serum samples from eight participants during the XV winter-over at Concordia base (Antarctic expedition) collected at defined time points, including predeparture, constituted the key substrates for a specific metabolomics study. To ascertain acute changes and chronic adaptation to hypoxia, the metabolic profiles of the serum samples were analyzed using NMR spectroscopy, with principal components analysis (PCA) followed by partial least squares and orthogonal partial least squares discriminant analyses (PLS-DA and OPLS-DA) used as supervised classification methods. Multivariate data analyses clearly highlighted an adaptation period characterized by an increase in the levels of circulating glutamine and lipids, mobilized to supply the body energy needs. At the same time, a reduction in the circulating levels of glutamate and
Identifiants
pubmed: 37176166
pii: ijms24098459
doi: 10.3390/ijms24098459
pmc: PMC10179003
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Education, Universities and Research
ID : PNRA16_00047 project-Line A2
Organisme : Ministry of Education, Universities and Research
ID : PNRA18_0 0071_Prot. 20891.21-11-2019
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