Production of Diketopiperazine Derivatives by Pathway Engineering with Different Cyclodipeptide Synthases from Various

Diketopiperazines / metabolism Nitric Oxide Synthase Streptomyces / metabolism Peptide Synthases / metabolism
Streptomyces cyclodipeptide synthase tailoring enzyme tryptophan-containing cyclodipeptide

Journal

ACS synthetic biology
ISSN: 2161-5063
Titre abrégé: ACS Synth Biol
Pays: United States
ID NLM: 101575075

Informations de publication

Date de publication:
16 06 2023
Historique:
medline: 19 6 2023
pubmed: 15 5 2023
entrez: 15 5 2023
Statut: ppublish

Résumé

Cyclodipeptides from fungi and bacteria are often modified by different tailoring enzymes. They display various biological and pharmacological activities, and some derivatives are used as drugs. In a previous study, we elucidated the function of the silent guatrypmethine gene cluster from

Identifiants

DOI: 10.1021/acssynbio.3c00115 PMID: 37183364
pubmed: 37183364
doi: 10.1021/acssynbio.3c00115
doi:

Substances chimiques

Diketopiperazines 0
Nitric Oxide Synthase EC 1.14.13.39
Peptide Synthases EC 6.3.2.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1804-1812

Auteurs

Sina A Stierle (SA)

Institut für Pharmazeutische Biologie und Biotechnologie, Fachbereich Pharmazie, Philipps-Universität Marburg, 35037 Marburg, Germany.
ORCID: 0000-0002-5561-4486

Lauritz Harken (L)

Institut für Pharmazeutische Biologie und Biotechnologie, Fachbereich Pharmazie, Philipps-Universität Marburg, 35037 Marburg, Germany.

Shu-Ming Li (SM)

Institut für Pharmazeutische Biologie und Biotechnologie, Fachbereich Pharmazie, Philipps-Universität Marburg, 35037 Marburg, Germany.
ORCID: 0000-0003-4583-2655

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pipérazines › Pipérazinediones › Production of Diketopiperazine Derivatives by...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on CH-NH2 group donors › Amino-acid oxidoreductases › Nitric oxide synthase › Production of Diketopiperazine Derivatives by...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets sporulés à Gram positif › Streptomycetaceae › Streptomyces › Production of Diketopiperazine Derivatives by...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Ligases › Carbon-nitrogen ligases › Amino-acid ligases › Production of Diketopiperazine Derivatives by...