Asymmetric activation of dimeric GABA

Receptors, Metabotropic Glutamate / genetics Allosteric Regulation Receptors, G-Protein-Coupled Synaptic Transmission Glutamic Acid Receptors, GABA-B / genetics
G protein coupling GPCR allosteric modulator heterodimer homodimer

Journal

American journal of physiology. Cell physiology
ISSN: 1522-1563
Titre abrégé: Am J Physiol Cell Physiol
Pays: United States
ID NLM: 100901225

Informations de publication

Date de publication:
01 07 2023
Historique:
medline: 19 6 2023
pubmed: 15 5 2023
entrez: 15 5 2023
Statut: ppublish

Résumé

G protein-coupled receptors (GPCRs) represent the largest family of membrane proteins and are important drug targets. GPCRs are allosteric machines that transduce an extracellular signal to the cell by activating heterotrimeric G proteins. Herein, we summarize the recent advancements in the molecular activation mechanism of the γ-aminobutyric acid type B (GABA

Identifiants

DOI: 10.1152/ajpcell.00150.2022 PMID: 37184233
pubmed: 37184233
doi: 10.1152/ajpcell.00150.2022
doi:

Substances chimiques

Receptors, Metabotropic Glutamate 0
Receptors, G-Protein-Coupled 0
Glutamic Acid 3KX376GY7L
Receptors, GABA-B 0

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

C79-C89

Auteurs

Lei Liu (L)

Cellular Signaling Laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, and College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

Li Lin (L)

Cellular Signaling Laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, and College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

Cangsong Shen (C)

Cellular Signaling Laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, and College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

Philippe Rondard (P)

Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, Montpellier, France.
ORCID: 0000-0003-1134-2738

Jean-Philippe Pin (JP)

Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, Montpellier, France.

Chanjuan Xu (C)

Cellular Signaling Laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, and College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

Jianfeng Liu (J)

Cellular Signaling Laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, and College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
ORCID: 0000-0002-0284-8377

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteurs au glutamate › Récepteurs métabotropes au glutamate › Asymmetric activation of dimeric GABA
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Régulation allostérique › Asymmetric activation of dimeric GABA
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Asymmetric activation of dimeric GABA
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Transmission synaptique › Asymmetric activation of dimeric GABA
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés excitateurs › Acide glutamique › Asymmetric activation of dimeric GABA
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteurs GABA › Récepteurs GABA-B › Asymmetric activation of dimeric GABA