Absence of Tissue-Sparing Effects in Partial Proton FLASH Irradiation in Murine Intestine.
FLASH effect
intestine
lymphocyte depletion
proton irradiation
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
13 Apr 2023
13 Apr 2023
Historique:
received:
23
02
2023
revised:
07
04
2023
accepted:
11
04
2023
medline:
16
5
2023
pubmed:
16
5
2023
entrez:
16
5
2023
Statut:
epublish
Résumé
Ultra-high dose rate irradiation has been reported to protect normal tissues more than conventional dose rate irradiation. This tissue sparing has been termed the FLASH effect. We investigated the FLASH effect of proton irradiation on the intestine as well as the hypothesis that lymphocyte depletion is a cause of the FLASH effect. A 16 × 12 mm
Identifiants
pubmed: 37190197
pii: cancers15082269
doi: 10.3390/cancers15082269
pmc: PMC10137009
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NCI NIH HHS
ID : R01 CA266419
Pays : United States
Organisme : NIH HHS
ID : R01-CA266419
Pays : United States
Organisme : Damon Runyon Cancer Research Foundation
ID : Damon Runyon-Rachleff Innovation Award 57-19
Pays : United States
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