IRIS: Discovery of cancer immunotherapy targets arising from pre-mRNA alternative splicing.

Male Humans RNA Precursors / metabolism Alternative Splicing Leukocytes, Mononuclear / metabolism Receptors, Antigen, T-Cell Epitopes, T-Lymphocyte Immunotherapy Antigens, Neoplasm Peptides / metabolism Neoplasms / genetics
RNA splicing T cell receptors immunotherapy

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
23 05 2023
Historique:
medline: 18 5 2023
pubmed: 16 5 2023
entrez: 16 5 2023
Statut: ppublish

Résumé

Alternative splicing (AS) is prevalent in cancer, generating an extensive but largely unexplored repertoire of novel immunotherapy targets. We describe

Identifiants

DOI: 10.1073/pnas.2221116120 PMID: 37192158 PMC: PMC10214192
pubmed: 37192158
doi: 10.1073/pnas.2221116120
pmc: PMC10214192
doi:

Substances chimiques

RNA Precursors 0
Receptors, Antigen, T-Cell 0
Epitopes, T-Lymphocyte 0
Antigens, Neoplasm 0
Peptides 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2221116120

Subventions

Organisme : NCI NIH HHS
ID : P50 CA092131
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA197633
Pays : United States

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Auteurs

Yang Pan (Y)

Bioinformatics Interdepartmental Graduate Program, University of California, Los Angeles, CA 90095.
Center for Computational and Genomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.

John W Phillips (JW)

Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA 90095.

Beatrice D Zhang (BD)

Center for Computational and Genomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.
ORCID: 0000-0003-1636-600X

Miyako Noguchi (M)

Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA 90095.

Eric Kutschera (E)

Center for Computational and Genomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.
ORCID: 0000-0002-2160-1820

Jami McLaughlin (J)

Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA 90095.

Pavlo A Nesterenko (PA)

Molecular Biology Institute, University of California, Los Angeles, CA 90095.
ORCID: 0000-0001-9841-8170

Zhiyuan Mao (Z)

Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.

Nathanael J Bangayan (NJ)

Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.

Robert Wang (R)

Center for Computational and Genomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.
Graduate Group in Genomics and Computational Biology, University of Pennsylvania, Philadelphia, PA 19104.

Wendy Tran (W)

Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA 90095.

Harry T Yang (HT)

Bioinformatics Interdepartmental Graduate Program, University of California, Los Angeles, CA 90095.
ORCID: 0000-0001-9125-5962

Yuanyuan Wang (Y)

Bioinformatics Interdepartmental Graduate Program, University of California, Los Angeles, CA 90095.
Center for Computational and Genomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.

Yang Xu (Y)

Center for Computational and Genomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.
Graduate Group in Genomics and Computational Biology, University of Pennsylvania, Philadelphia, PA 19104.

Matthew B Obusan (MB)

Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA 90095.
ORCID: 0000-0002-9579-2308

Donghui Cheng (D)

Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, CA 90095.

Alex H Lee (AH)

Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.

Kathryn E Kadash-Edmondson (KE)

Center for Computational and Genomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.

Ameya Champhekar (A)

Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.

Cristina Puig-Saus (C)

Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095.
Parker Institute for Cancer Immunotherapy, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
ORCID: 0000-0002-3014-3649

Antoni Ribas (A)

Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, CA 90095.
Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095.
Parker Institute for Cancer Immunotherapy, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
ORCID: 0000-0003-3669-8458

Robert M Prins (RM)

Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095.
Parker Institute for Cancer Immunotherapy, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.

Christopher S Seet (CS)

Molecular Biology Institute, University of California, Los Angeles, CA 90095.
Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, CA 90095.
Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095.

Gay M Crooks (GM)

Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, CA 90095.
Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095.
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Division of Pediatric Hematology-Oncology, Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.

Owen N Witte (ON)

Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA 90095.
Molecular Biology Institute, University of California, Los Angeles, CA 90095.
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, CA 90095.
Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095.
Parker Institute for Cancer Immunotherapy, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
ORCID: 0000-0003-4461-4533

Yi Xing (Y)

Center for Computational and Genomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.
Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA 90095.
Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Department of Biomedical and Health Informatics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › IRIS: Discovery of cancer immunotherapy...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › Précurseurs des ARN › IRIS: Discovery of cancer immunotherapy...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Maturation post-transcriptionnelle des ARN › Épissage des ARN › Épissage alternatif › IRIS: Discovery of cancer immunotherapy...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › IRIS: Discovery of cancer immunotherapy...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux antigènes › Récepteurs aux antigènes des cellules T › IRIS: Discovery of cancer immunotherapy...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Épitopes › Déterminants antigéniques des lymphocytes T › IRIS: Discovery of cancer immunotherapy...
questionsmedicales.fr › Thérapeutique › Biothérapie › Immunothérapie › IRIS: Discovery of cancer immunotherapy...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes néoplasiques › IRIS: Discovery of cancer immunotherapy...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › IRIS: Discovery of cancer immunotherapy...
questionsmedicales.fr › Tumeurs › IRIS: Discovery of cancer immunotherapy...