Engineering ketoreductases for the enantioselective synthesis of chiral alcohols.

Alcohols Stereoisomerism Oxidation-Reduction Ketones / metabolism Protein Engineering Catalysis

Journal

Chemical communications (Cambridge, England)
ISSN: 1364-548X
Titre abrégé: Chem Commun (Camb)
Pays: England
ID NLM: 9610838

Informations de publication

Date de publication:
15 Jun 2023
Historique:
medline: 19 6 2023
pubmed: 17 5 2023
entrez: 17 5 2023
Statut: epublish

Résumé

The use of engineered ketoreductases (KREDS), both as whole microbial cells and isolated enzymes, in the highly enantiospecific reduction of prochiral ketones is reviewed. The homochiral alcohol products are key intermediates in, for example, pharmaceuticals synthesis. The application of sophisticated protein engineering and enzyme immobilisation techniques to increase industrial viability are discussed.

Identifiants

DOI: 10.1039/d3cc01474f PMID: 37194698
pubmed: 37194698
doi: 10.1039/d3cc01474f
doi:

Substances chimiques

Alcohols 0
Ketones 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

7518-7533

Auteurs

Li Qiao (L)

College of Materials, Chemistry and Chemical Engineering; Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education; Hangzhou Normal University, Zhejiang Province, Hangzhou, 311121, Zhejiang, P. R. China. waming@hznu.edu.cn.

Zhiyuan Luo (Z)

College of Materials, Chemistry and Chemical Engineering; Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education; Hangzhou Normal University, Zhejiang Province, Hangzhou, 311121, Zhejiang, P. R. China. waming@hznu.edu.cn.

Haomin Chen (H)

College of Materials, Chemistry and Chemical Engineering; Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education; Hangzhou Normal University, Zhejiang Province, Hangzhou, 311121, Zhejiang, P. R. China. waming@hznu.edu.cn.

Pengfei Zhang (P)

College of Materials, Chemistry and Chemical Engineering; Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education; Hangzhou Normal University, Zhejiang Province, Hangzhou, 311121, Zhejiang, P. R. China. waming@hznu.edu.cn.
ORCID: 0000-0001-9859-0237

Anming Wang (A)

College of Materials, Chemistry and Chemical Engineering; Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education; Hangzhou Normal University, Zhejiang Province, Hangzhou, 311121, Zhejiang, P. R. China. waming@hznu.edu.cn.
ORCID: 0000-0002-8480-5783

Roger A Sheldon (RA)

Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, PO Wits. 2050, Johannesburg, South Africa. roger.sheldon@wits.ac.za.
Department of Biotechnology, Section BOC, Delft University of Technology, van der Maasweg 9, 2629 HZ Delft, The Netherlands.
ORCID: 0000-0001-6867-2119

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Alcools › Engineering ketoreductases for the...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes de chimie organique › Isomérie › Stéréoisomérie › Engineering ketoreductases for the...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Engineering ketoreductases for the...
questionsmedicales.fr › Composés chimiques organiques › Cétones › Engineering ketoreductases for the...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Génie génétique › Ingénierie des protéines › Engineering ketoreductases for the...
questionsmedicales.fr › Phénomènes chimiques › Catalyse › Engineering ketoreductases for the...