B7-H3 immunoregulatory roles in cancer.

Humans CD8-Positive T-Lymphocytes / metabolism B7 Antigens / genetics Neoplasms / therapy Immunotherapy Antibodies, Monoclonal
B7 homolog 3 (B7-H3) Cancer Programmed death-ligand 1 (PD-L1) Resistance

Journal

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295

Informations de publication

Date de publication:
Jul 2023
Historique:
received: 10 04 2023
revised: 06 05 2023
accepted: 12 05 2023
medline: 29 5 2023
pubmed: 18 5 2023
entrez: 17 5 2023
Statut: ppublish

Résumé

B7 homolog 3 (B7-H3, also called CD276) is a checkpoint of B7 family that is aberrantly and consistently expressed in several human cancers, and its overexpression correlates with weak prognosis. B7-H3 is expressed on a number of cells, and it acts as a driver of immune evasion. This is mediated through hampering T cell infiltration and promoting exhaustion of CD8

Identifiants

DOI: 10.1016/j.biopha.2023.114890 PMID: 37196544
pubmed: 37196544
pii: S0753-3322(23)00680-7
doi: 10.1016/j.biopha.2023.114890
pii:
doi:

Substances chimiques

B7 Antigens 0
Antibodies, Monoclonal 0
CD276 protein, human 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

114890

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest None.

Auteurs

Keywan Mortezaee (K)

Department of Anatomy, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran. Electronic address: keywan987@yahoo.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › B7-H3 immunoregulatory roles in cancer.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › B7-H3 immunoregulatory roles in cancer.
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Antigènes B7 › B7-H3 immunoregulatory roles in cancer.
questionsmedicales.fr › Tumeurs › B7-H3 immunoregulatory roles in cancer.
questionsmedicales.fr › Thérapeutique › Biothérapie › Immunothérapie › B7-H3 immunoregulatory roles in cancer.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps monoclonaux › B7-H3 immunoregulatory roles in cancer.