Senescence-related impairment of autophagy induces toxic intraneuronal amyloid-β accumulation in a mouse model of amyloid pathology.

Humans Mice Animals Neurons / metabolism Amyloid beta-Peptides / metabolism Alzheimer Disease / pathology Brain / pathology Autophagy Amyloid beta-Protein Precursor / genetics Mice, Transgenic Disease Models, Animal
Alzheimer’s disease Autophagy Cellular senescence Intraneuronal Aβ Telomere shortening

Journal

Acta neuropathologica communications
ISSN: 2051-5960
Titre abrégé: Acta Neuropathol Commun
Pays: England
ID NLM: 101610673

Informations de publication

Date de publication:
17 05 2023
Historique:
received: 05 05 2023
accepted: 07 05 2023
medline: 19 5 2023
pubmed: 18 5 2023
entrez: 17 5 2023
Statut: epublish

Résumé

Aging is the main risk factor for Alzheimer's disease (AD) and other neurodegenerative pathologies, but the molecular and cellular changes underlying pathological aging of the nervous system are poorly understood. AD pathology seems to correlate with the appearance of cells that become senescent due to the progressive accumulation of cellular insults causing DNA damage. Senescence has also been shown to reduce the autophagic flux, a mechanism involved in clearing damaged proteins from the cell, and such impairment has been linked to AD pathogenesis. In this study, we investigated the role of cellular senescence on AD pathology by crossing a mouse model of AD-like amyloid-β (Aβ) pathology (5xFAD) with a mouse model of senescence that is genetically deficient for the RNA component of the telomerase (Terc

Identifiants

DOI: 10.1186/s40478-023-01578-x PMID: 37198698 PMC: PMC10189946
pubmed: 37198698
doi: 10.1186/s40478-023-01578-x
pii: 10.1186/s40478-023-01578-x
pmc: PMC10189946
doi:

Substances chimiques

Amyloid beta-Peptides 0
Amyloid beta-Protein Precursor 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

82

Informations de copyright

© 2023. The Author(s).

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Auteurs

Nuria Suelves (N)

Aging and Dementia Group, Cellular and Molecular Division (CEMO), Institute of Neuroscience (IoNS), UCLouvain, Brussels, Belgium.

Shirine Saleki (S)

Aging and Dementia Group, Cellular and Molecular Division (CEMO), Institute of Neuroscience (IoNS), UCLouvain, Brussels, Belgium.

Tasha Ibrahim (T)

Aging and Dementia Group, Cellular and Molecular Division (CEMO), Institute of Neuroscience (IoNS), UCLouvain, Brussels, Belgium.

Debora Palomares (D)

Aging and Dementia Group, Cellular and Molecular Division (CEMO), Institute of Neuroscience (IoNS), UCLouvain, Brussels, Belgium.

Sebastiaan Moonen (S)

Laboratory for Neuropathology, Department of Imaging and Pathology, Leuven Brain Institute (LBI), KU Leuven, Leuven, Belgium.
Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, Leuven Brain Institute (LBI), KU Leuven, Leuven, Belgium.
Vlaams Instituut Voor Biotechnologie (VIB) Center for Brain and Disease Research, VIB, Leuven, Belgium.

Marta J Koper (MJ)

Laboratory for Neuropathology, Department of Imaging and Pathology, Leuven Brain Institute (LBI), KU Leuven, Leuven, Belgium.
Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, Leuven Brain Institute (LBI), KU Leuven, Leuven, Belgium.
Vlaams Instituut Voor Biotechnologie (VIB) Center for Brain and Disease Research, VIB, Leuven, Belgium.

Céline Vrancx (C)

Aging and Dementia Group, Cellular and Molecular Division (CEMO), Institute of Neuroscience (IoNS), UCLouvain, Brussels, Belgium.
Laboratory for Membrane Trafficking, Department of Neurosciences, Vlaams Instituut Voor Biotechnologie (VIB) Center for Brain and Disease Research, KU Leuven, Leuven, Belgium.

Devkee M Vadukul (DM)

Aging and Dementia Group, Cellular and Molecular Division (CEMO), Institute of Neuroscience (IoNS), UCLouvain, Brussels, Belgium.
Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, UK.

Nicolas Papadopoulos (N)

Ludwig Institute for Cancer Research, Brussels, Belgium.
SIGN Unit, de Duve Institute, UCLouvain, Brussels, Belgium.

Nikenza Viceconte (N)

Genetic and Epigenetic Alterations of Genomes Unit, de Duve Institute, UCLouvain, Brussels, Belgium.
CENTOGENE GmbH, 18055, Rostock, Germany.

Eloïse Claude (E)

Genetic and Epigenetic Alterations of Genomes Unit, de Duve Institute, UCLouvain, Brussels, Belgium.

Rik Vandenberghe (R)

Laboratory for Cognitive Neurology, Department of Neurosciences, Leuven Brain Institute (LBI), KU Leuven (University of Leuven), Leuven, Belgium.
Department of Neurology, University Hospital Leuven, Leuven, Belgium.

Christine A F von Arnim (CAF)

Department of Neurology, University of Ulm, Ulm, Germany.
Department of Geriatrics, University Medical Center Göttingen, Göttingen, Germany.

Stefan N Constantinescu (SN)

Ludwig Institute for Cancer Research, Brussels, Belgium.
SIGN Unit, de Duve Institute, UCLouvain, Brussels, Belgium.
Walloon Excellence in Life Sciences and Biotechnology (WELBIO), Brussels, Belgium.
Nuffield Department of Medicine, Ludwig Institute for Cancer Research, Oxford University, Oxford, UK.

Dietmar Rudolf Thal (DR)

Laboratory for Neuropathology, Department of Imaging and Pathology, Leuven Brain Institute (LBI), KU Leuven, Leuven, Belgium.
Department of Pathology, University Hospital Leuven, Leuven, Belgium.

Anabelle Decottignies (A)

Genetic and Epigenetic Alterations of Genomes Unit, de Duve Institute, UCLouvain, Brussels, Belgium.

Pascal Kienlen-Campard (P)

Aging and Dementia Group, Cellular and Molecular Division (CEMO), Institute of Neuroscience (IoNS), UCLouvain, Brussels, Belgium. pascal.kienlen-campard@uclouvain.be.
ORCID: 0000-0003-1086-2942

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Senescence-related impairment of autophagy...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Senescence-related impairment of autophagy...
questionsmedicales.fr › Eucaryotes › Animaux › Senescence-related impairment of autophagy...
questionsmedicales.fr › Cellules › Neurones › Senescence-related impairment of autophagy...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › Senescence-related impairment of autophagy...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Senescence-related impairment of autophagy...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Senescence-related impairment of autophagy...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Autophagie › Senescence-related impairment of autophagy...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines sécrétoires inhibitrices de protéinases › Protéase nexines › Précurseur de la protéine bêta-amyloïde › Senescence-related impairment of autophagy...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Senescence-related impairment of autophagy...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Senescence-related impairment of autophagy...